Glutathione

Glutathione

Proceedings of the Symposium Held at Ridgefield, Connecticut, November, 1953

1st Edition - January 1, 1954

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  • Editors: S. Colowick, D. R. Schwarz, A. Lazarow
  • eBook ISBN: 9781483261508

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Description

Glutathione: A Symposium covers the proceedings of the symposium held in Ridgefield, Connecticut in November 1953. The book focuses on the chemistry, characteristics, reactions, and properties of glutathione (GSH). The selection first offers information on mercaptans and disulfides, reactivity of the sulfhydryl group in GSH and related peptides, and chemistry and properties of GSH. Discussions focus on isolation and occurrence of GSH, properties of GSH, general chemistry of acidity, oxidation, and disulfides, and application to the structure of GSH. The text then examines thiol-thiolester complex formation, methods of GSH assay, and paper chromatography of GSH and its hydrolysis products. The publication takes a look at histochemical experiments on sulfhydryls and disulfides, enzymatic oxidation and reduction of GSH, and biosynthesis of GSH. Topics include synthesis of GSH from the constituent amino acids, enzymatic oxidation of GSH, and methods for demonstrating protein-bound sulfhydryl and disulfide groups in tissues. The selection is a dependable reference for researchers interested in the chemistry, reactions, and properties of glutathione.

Table of Contents


  • List of Contributors

    Preface

    Acknowledgment

    Properties and Organic Chemistry

    Mercaptans and Disulfides; Some Physics, Chemistry, and Speculation

    Discussion

    The Reactivity of the Sulfhydryl Group in Glutathione and Related Peptides

    Discussion

    Chemistry and Properties of Glutathione

    Thiol-Thiolester Complex Formation

    Discussion

    The Methods for Detection and Assay of Glutathione and Sulfhydryl Compounds

    Methods of Glutathione Assay—A Review of Classical Methods

    Discussion

    Paper Chromatography of Glutathione and Its Hydrolysis Products

    Histochemical Experiments on Sulfhydryls and Disulfides

    Discussion

    Biochemical Mechanisms

    The Enzymatic Oxidation and Reduction of Glutathione

    Discussion

    The Biosynthesis of Glutathione

    Thioesterase and γ-Glutamyl Activation

    Biosynthesis of Component Amino Acids of Glutathione in the Rat

    Discussion

    Glutathione in Relation to Transpeptidation Reactions

    γ-Glutamyl Transfer Reactions

    Cysteine-Containing Peptide Sequences in Ovalbumin and Ribonuclease

    Discussion

    Glutathione as a Coenzyme in Intermediary Metabolism

    The Coenzyme Function of Glutathione in cis-trans Isomerization

    Contrasting Changes in Blood Level of Glutathione and Sulfhydryl, Apparently in Association with the Formation of Methemoglobin

    Discussion

    The Role of Sulfhydryl Compounds in Acyl-Transfer Reactions

    The Enzymatic Hydrolysis of S-Acetyl and S-Butyryl Glutathione

    Discussion

    SH and Growth

    Discussion

    Physiological Actions and Clinical Aspects

    Relation of Glutathione to Hormone Action and Diabetes

    Increased Blood Sulfhydryl in Rats and Guinea Pigs Treated with ACTH and Cortisone

    Discussion

    Glutathione in Radiation Injury

    Remarks Concerning Sulfhydryl Protection against Radiation Injury

    Oxygen Poisoning and X-irradiation : A Mechanism in Common

    The Metabolism of Injected Radioactive Glutathione (S35) in X-irradiated and Non-irradiated Mice

    Protective Effect of Glutathione against Potassium Overdosage

    Glutathione and Protein Oxidation and Precipitation in the Process of Aging and Cataract Formation in the Lens

    Glutathione in Human Disease

    Discussion

    Author Index

    Subject Index

Product details

  • No. of pages: 352
  • Language: English
  • Copyright: © Academic Press 1954
  • Published: January 1, 1954
  • Imprint: Academic Press
  • eBook ISBN: 9781483261508

About the Editors

S. Colowick

D. R. Schwarz

A. Lazarow

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