Glutathione - 1st Edition - ISBN: 9781483229003, 9781483261508

Glutathione

1st Edition

Proceedings of the Symposium Held at Ridgefield, Connecticut, November, 1953

Editors: S. Colowick D. R. Schwarz A. Lazarow
eBook ISBN: 9781483261508
Imprint: Academic Press
Published Date: 1st January 1954
Page Count: 352
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Description

Glutathione: A Symposium covers the proceedings of the symposium held in Ridgefield, Connecticut in November 1953. The book focuses on the chemistry, characteristics, reactions, and properties of glutathione (GSH).

The selection first offers information on mercaptans and disulfides, reactivity of the sulfhydryl group in GSH and related peptides, and chemistry and properties of GSH. Discussions focus on isolation and occurrence of GSH, properties of GSH, general chemistry of acidity, oxidation, and disulfides, and application to the structure of GSH. The text then examines thiol-thiolester complex formation, methods of GSH assay, and paper chromatography of GSH and its hydrolysis products.

The publication takes a look at histochemical experiments on sulfhydryls and disulfides, enzymatic oxidation and reduction of GSH, and biosynthesis of GSH. Topics include synthesis of GSH from the constituent amino acids, enzymatic oxidation of GSH, and methods for demonstrating protein-bound sulfhydryl and disulfide groups in tissues.

The selection is a dependable reference for researchers interested in the chemistry, reactions, and properties of glutathione.

Table of Contents


List of Contributors


Preface


Acknowledgment


Properties and Organic Chemistry


Mercaptans and Disulfides; Some Physics, Chemistry, and Speculation


Discussion


The Reactivity of the Sulfhydryl Group in Glutathione and Related Peptides


Discussion


Chemistry and Properties of Glutathione


Thiol-Thiolester Complex Formation


Discussion


The Methods for Detection and Assay of Glutathione and Sulfhydryl Compounds


Methods of Glutathione Assay—A Review of Classical Methods


Discussion


Paper Chromatography of Glutathione and Its Hydrolysis Products


Histochemical Experiments on Sulfhydryls and Disulfides


Discussion


Biochemical Mechanisms


The Enzymatic Oxidation and Reduction of Glutathione


Discussion


The Biosynthesis of Glutathione


Thioesterase and γ-Glutamyl Activation


Biosynthesis of Component Amino Acids of Glutathione in the Rat


Discussion


Glutathione in Relation to Transpeptidation Reactions


γ-Glutamyl Transfer Reactions


Cysteine-Containing Peptide Sequences in Ovalbumin and Ribonuclease


Discussion


Glutathione as a Coenzyme in Intermediary Metabolism


The Coenzyme Function of Glutathione in cis-trans Isomerization


Contrasting Changes in Blood Level of Glutathione and Sulfhydryl, Apparently in Association with the Formation of Methemoglobin


Discussion


The Role of Sulfhydryl Compounds in Acyl-Transfer Reactions


The Enzymatic Hydrolysis of S-Acetyl and S-Butyryl Glutathione


Discussion


SH and Growth


Discussion


Ph

Details

No. of pages:
352
Language:
English
Copyright:
© Academic Press 1954
Published:
Imprint:
Academic Press
eBook ISBN:
9781483261508

About the Editor

S. Colowick

D. R. Schwarz

A. Lazarow

Ratings and Reviews