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Table of Contents
- Chapter 1 Nomenclatures for mammalian soluble glutathione transferases ; Chapter 2 Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease; Chapter 3 Regulation of GST-P gene expression during hepatocarcinogenesis; Chapter 4 Human Glutathone Transferase Zeta; Chapter 5 Characterization of the Omega class of glutathione transferases; Chapter 6 Alternative splicing of GST transcripts; Chapter 7 Disruption of the GST Pi class genes ; Chapter 8 Microsomal glutathione transferase 1; Chapter 9 Human microsomal Prostaglandin E Synthase 1 — A member of the MAPEG protein superfamily ; Chapter 10 Two-dimensional crystallization and electron crystallography of MAPEG proteins; Chapter 11 Pant Glutathione Transferase; Chapter 12 Phylogenies of Glutathione Transferase Families; Chapter 13 Drosophila Glutathione S-Transferases; Chapter 14 Mosquito glutathione transferases 1; Chapter 15 Glutathione S-transferase from malarial parasites - structural and functional aspects; Chapter 16 Optimizing of heterologous expression of glutathione transferase ; Chapter 17 Human glutathione transferase A3-3 active as steroid double-bond Isomerase ; Chapter 18 A subclass of Mu glutathione S-tranferases selectively expressed in testis and brain; Chapter 19 Glutathione S-tranferases as regulators of kinase pathways and anticancer drug targets ; Chapter 20 Modification of N-acetyltransferases and glutathione S-transferases by coffee components. Possible relevance for cancer risk ; Chapter 21 Activation of alkylhalides by glutathione transferases ; Chapter 22 Peptide phage display for probing GST-protein Interactions; Chapter 23 Fosfomycin resistance proteins: A nexus of glutathione transferases and epoxide hydrolases in metalloenzyme superfamily; Chapter 24 Regulation of 4-Hydroxynonenal mediated signaling by glutathione S-transferases; Chapter 25 GGT gene expression of y-Glutamyltranspeptidase; Chapter 26 y-glutamyltranspeptidase: Disulfide bridges, propeptide cleavage and activation in the endoplasmic recticulum ; Chapter 27 Gamma-Glutamyl Transpeptidase substrate specificity and catalytic mechanism ; Chapter 28 y-Glutamyl transpeptidase in glutathione biosynthesis; Chapter 29 Prooxidant reactions promoted by soluble and cell-bound y-glutamyltransferase activity
- No. of pages: 928
- Language: English
- Copyright: © Academic Press 2005
- Published: November 22, 2005
- Imprint: Academic Press
About the Serial Volume Editors
Affiliations and Expertise
Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l’Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California.
He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology:
Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the “Antioxidant Network” regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell’s redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.