Glutathione Centennial

Glutathione Centennial

Molecular Perspectives and Clinical Implications

1st Edition - December 28, 1989

Write a review

  • Editor: Naoyuki Taniguchi
  • eBook ISBN: 9780323149624

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Glutathione Centennial: Molecular Perspectives and Clinical Implications is a collection of papers presented at the international symposium by the same titles, held in Osaka, Japan on December 1-4, 1988. This symposium concentrates on the developments is glutathione field, especially those related to molecular and clinical problems. This book is organized into five parts encompassing 30 chapters. Part I deals with the metabolic regulation, thermodynamic and kinetic properties, and enzyme regulation of glutathione. Part II examines the gene expression and molecular mechanism of glutathione-related enzymes, while Part III explores the association between carcinogenesis, xenobiotic compounds, and glutathione. Part IV highlights the clinical implications of glutathione, particularly its effect on vasospasm in subarachnoid hemorrhage and experimental hepatitis. Part V discusses the mechanism and regulation of biological transport of glutathione. This book will be of great value to glutathione enthusiasts and to many scientists in the brad fields of biology and medicine, and to their students.

Table of Contents

  • Contributors


    Part I. Metabolic Regulation of Glutathione

    1. On the Biochemistry of Glutathione

    2. Glutathione-Linked Enzymes in Detoxication Reactions

    3. The Role of Glutathione in Mitochondria

    4. Regulation of Glutathione Level in Primary Cultured Hepatocytes

    5. Thermodynamic and Kinetic Constraints on Thiol/Disulfide Exchange Involving Glutathione Redox Buffers

    6. Regulation of Inhibitory Activity of Cysteine Proteinase Inhibitor (Cystatin β) by Glutathione Mediated Covalent Modification

    Part II. Gene Expression and Molecular Mechanism of Glutathione-Related Enzymes

    7. Structure and Catalytic Mechanism of Glutathione Peroxidase

    8. Regulation of Rat Glutathione Transferase Ρ Gene Expression

    9. Regulation of Glutathione S-Transferase Gene Expression

    10. Construction of Mouse Glutathione Peroxidase Gene and Its Expression

    11. Regulation of Human Glutathione Peroxidase Gene Expression by Selenium

    12. Escherichia Coli K-12 Mutants Lacking γ-Glutamyltranspeptidase and Molecular Cloning of ggt Gene

    13. Heterogeneity in γ-Glutamyltranspeptidase Structure: Evidence for O-Linked Glycosylation and Two Forms of mRNA for the Rat Renal Enzyme

    14. Glutathione-Degrading Enzymes of Brush Border: Molecular and Functional Aspects

    Part III. Carcinogenesis, Xenobiotic Compounds, and Glutathione

    15. Enzymatic and Molecular Basis for Cancer-Associated Changes in γ-Glutamyl Transpeptidase

    16. Induction of γ-Glutamyltranspeptidase in Rat Liver Exposed to Carcinogen with Special Reference to Carcinogen-Resistant Rats

    17. Glutathione S-Transferases: Structure and Function

    18. Properties and Functions of Neutral and Acidic Glutathione S-Transferases

    19. A Biochemical Mechanism for the Oxidation of Glutathione by Xenobiotic Thiols

    Part IV. Clinical Implications of Glutathione

    20. L-Buthionine-SR-Sulfoximine: Mechanism of Action, Resolution of Diastereomers and Use as a Chemotherapeutic Agent

    21. Acquired Resistance of Tumor Cells to L-Phenylalanine Mustard: Implications for the Design of a Clinical Trial Involving Glutathione Depletion

    22. Effects of Glutathione and Glutathione Isopropyl Ester on Vasospasm in Subarachnoid Hemorrhage

    23. The Role of Glutathione and Its Eicosanoid Adducts in Experimental Hepatitis in Mice

    24. The Effect of Manganese on Glutathione Peroxidase Activity and Selenium Content in Rats

    Part V. Transport of Glutathione

    25. Glutathione Conjugates: Transport from the Cell and Intracellular Effects

    26. Glutathione Disulfide-Stimulated Mg2+-ATPase of Human Erythrocytes

    27. Dynamic Aspects of Glutathione Metabolism and Transport During Oxidative Stress

    28. Hepatic Glutathione Transport

    29. Regulation of Glutathione Level by Amino Acid Transport

    30. Role of Glutathione Transport in Extrahepatic Detoxication


Product details

  • No. of pages: 458
  • Language: English
  • Copyright: © Academic Press 1989
  • Published: December 28, 1989
  • Imprint: Academic Press
  • eBook ISBN: 9780323149624

About the Editor

Naoyuki Taniguchi

Ratings and Reviews

Write a review

There are currently no reviews for "Glutathione Centennial"