Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus - 1st Edition - ISBN: 9780128001011, 9780128002940

Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus, Volume 121

1st Edition

Serial Editors: Ya-Xiong Tao
eBook ISBN: 9780128002940
Hardcover ISBN: 9780128001011
Imprint: Academic Press
Published Date: 14th January 2014
Page Count: 536
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents



Chapter One. G Protein-Coupled Receptors as Regulators of Glucose Homeostasis and Therapeutic Targets for Diabetes Mellitus



1 Introduction

2 Regulation of Glucose Homeostasis by GPCRs in the Central Nervous System

3 Regulation of Glucose Homeostasis by GPCRs for Peptides from Endocrine Pancreas

4 Regulation of Insulin Secretion by GPCRs

5 Regulation of Incretin Secretion by GPCRs

6 Regulation of Glucose Homeostasis by Orphan GPCRs

7 Summary



Chapter Two. Regulation of Glucose Homeostasis by GLP-1


List of Abbreviations

1 Introduction

2 GLP-1 Biosynthesis, Secretion, and Degradation

3 Insulinotropic and Growth Factor Properties of GLP-1

4 Molecular Basis of GLP-1 Receptor Activation

5 Control of Pancreatic β-Cell Insulin Secretion by GLP-1

6 Altered GLP-1 Action in a Rodent Model of Insulin Resistance

7 Glucoregulatory Properties of GLP-1 Mediated by the Nervous System

8 GLP-1 Receptor Agonists

9 DPP-IV Inhibitors

10 GLP-1-Based Strategies for the Treatment of T2DM

11 Improved Glucoregulation After Bariatric Surgery

12 Safety Considerations for GLP-1-Based Therapeutics

13 Conclusion



Chapter Three. Physiology and Therapeutics of the Free Fatty Acid Receptor GPR40



1 Introduction

2 Molecular Cloning and Tissue Distribution of GPR40

3 Physiology of GPR40

4 Pharmacology of GPR40

5 Pathophysiology of GPR40

6 Conclusions



Chapter Four. Targeting GPR119 for the Potential Treatment of Type 2 Diabetes Mellitus



1 Introduction

2 Molecular Cloning and Localization of GPR119

3 Physiology of GPR119

4 Pharmacology of GPR119

5 Conclusions



Chapter Five. Enhanced Skeletal Muscle for Effective Glucose Homeostasis


1 Introduction

2 Skeletal Muscle and Glucose Homeostasis

3 Skeletal Muscle Formation

4 Myogenic Regulatory Factors

5 Postnatal Development of Skeletal Muscle

6 Myostatin and Skeletal Muscle Mass

7 Enhanced Muscle Growth for Preventing Diabetes

8 Concluding Remarks



Chapter Six. Factors Affecting Insulin-Regulated Hepatic Gene Expression



1 Introduction

2 Insulin Secretion, Its Signaling Pathways, and Its Regulated Hepatic Gene Expression

3 Effects of Hormone and Nutrient on Insulin-Regulated Hepatic Gene Expression

4 Drugs and Phytochemicals Affecting Hepatic Insulin Action

5 Perspectives and Future Directions



Chapter Seven. The Roles of Peroxisome Proliferator-Activated Receptors in the Metabolic Syndrome


1 Introduction

2 Tissue Distribution of PPARs Suggests Key Role in Lipid and Glucose Metabolism

3 Prototypic Nuclear Receptor Domains of PPARs

4 PPAR Ligands (Endogenous and Synthetic) and Coregulators

5 Key Target Genes of PPARs Related to the Metabolic Syndrome

6 Lessons Learned from Clinical Use of TZD Class of Antidiabetic Drugs

7 New, Novel PPAR Ligands for Treatment of the Metabolic Syndrome

8 Summary



Chapter Eight. Free Fatty Acids and Skeletal Muscle Insulin Resistance


1 Historic Overview of the Scientific Understanding of Insulin Resistance

2 Lipids and Skeletal Muscle Insulin Resistance

3 Saturated Versus Unsaturated FFAs and Insulin Resistance

4 Additional Insights Into Mechanisms Involved Into FFA-Induced Muscle Insulin Resistance

5 FFAs, Mitochondrial Function, and Insulin Resistance

6 Is FFA-Induced Insulin Resistance a Cellular Adaptation Process?

7 Clinical Perspectives and Therapeutic Implications

8 Conclusions


Chapter Nine. Adiponectin Signaling and Metabolic Syndrome


1 Introduction

2 Metabolic Syndrome and the Limitation of Current Treatment

3 Adiponectin and Adiponectin Receptors

4 Adiponectin Signaling in Key Metabolic Cells/Tissues Related to Metabolic Syndrome

5 Summary


Chapter Ten. Regulation of Pancreatic Islet Beta-Cell Mass by Growth Factor and Hormone Signaling



1 Introduction

2 GH, PRL, and Their Receptor Signaling and Actions in Beta Cells

3 IGF-1 and Its Receptor Signaling and Actions in Beta Cells

4 GH–IGF-1 Signaling Cross Talk and Collaborative Roles in Regulation of Beta-Cell Mass

5 Concluding Remarks



Chapter Eleven. The Impact of Dietary Methionine Restriction on Biomarkers of Metabolic Health



1 Rationale for Study of Dietary Methionine Restriction

2 Origins of Dietary Methionine Restriction as an Experimental Approach to Increase Longevity

3 Anti-Inflammatory Responses to Dietary Methionine Restriction and Longevity

4 Effects of Dietary MR on Energy Intake and Adiposity

5 Effects of Dietary MR on Energy Expenditure

6 Effects of Dietary MR on Fuel Selection and Metabolic Flexibility

7 Effects of Dietary MR on Hepatic Lipid Metabolism: Transcriptional Mechanisms

8 Transcriptional Effects of Dietary MR on Adipose Tissue

9 Sensing of Dietary MR

10 Perspectives and Future Directions



Chapter Twelve. Carbohydrate Metabolism and Pathogenesis of Diabetes Mellitus in Dogs and Cats


1 Introduction

2 The Dog

3 The Cat


Chapter Thirteen. Impaired Insulin Signaling and Mechanisms of Memory Loss



1 Introduction

2 Diabetes and Cognitive Deficits

3 Central Insulin Regulation

4 Insulin Resistance and Hallmarks of Neurodegeneration

5 Common Mediators of Insulin Resistance and Cognitive Dysfunction

6 Insulin Resistance and Hippocampal Dysfunction

7 Role of IGF in Cognitive Function

8 Animal Models of Insulin Signaling Deficits

9 Role of Antidiabetes Drugs in the Treatment of Cognitive Dysfunction

10 Summary



Chapter Fourteen. The Role of PPARδ Signaling in the Cardiovascular System


1 Introduction

2 Expression of PPARδ in the Cardiovascular System

3 The Role of PPARδ in Regulating the Function of Endothelial Cells

4 The Roles of PPARδ in the Vascular Smooth Muscle Cells

5 The Role of PPARδ in Regulating Macrophage Function

6 The Role of PPARδ in Fibroblast Proliferation

7 Roles of PPARδ in Myocardial Oxidative Metabolism

8 Anti-inflammatory Effect of PPARδ in Cardiomyocytes

9 Conclusions and Perspectives





Diabetes mellitus is a disease with tremendous health and economic burden. A better understanding of how normal glucose homeostasis is maintained and the pathogenesis is important to identify new ways for diabetes treatment. This book addresses multiple aspects of this area of research.

Key Features

  • Written by experts in the field
  • Informs on important topics related to the regulation of glucose homeostasis and the pathogenesis of diabetes mellitus, a field of intense research interest


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine, biomedical scientists and clinicians.


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Hardcover ISBN:


Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

Ratings and Reviews

About the Serial Editors

Ya-Xiong Tao Serial Editor

Dr. Ya-Xiong Tao is currently Associate Professor of Physiology at Auburn University College of Veterinary Medicine in Auburn, Alabama, USA. He has been working on several G protein-coupled receptors, including gonadotropin receptors regulating reproduction, and melanocortin receptors regulating energy and glucose homeostasis. He has published extensively in peer-reviewed biomedical journals and obtained funding for his research from National Institutes of Health, American Diabetes Association and American Heart Association, among others. He has delivered numerous lectures at universities and research institutes in USA. Canada, and China. He is visiting or guest professors at four universities and research institute in China. He has edited four volumes in Progress in Molecular Biology and Translational Science and is editing a volume of Advances in Pharmacology. He teaches several courses, including Physiology, Receptorology, and Molecular Endocrinology, for veterinarian and graduate students.

Affiliations and Expertise

College of Veterinary Medicine, Auburn University, AL, USA