Description

Diabetes mellitus is a disease with tremendous health and economic burden. A better understanding of how normal glucose homeostasis is maintained and the pathogenesis is important to identify new ways for diabetes treatment. This book addresses multiple aspects of this area of research.

Key Features

  • Written by experts in the field
  • Informs on important topics related to the regulation of glucose homeostasis and the pathogenesis of diabetes mellitus, a field of intense research interest

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine, biomedical scientists and clinicians.

Table of Contents

Contributors

Preface

Chapter One. G Protein-Coupled Receptors as Regulators of Glucose Homeostasis and Therapeutic Targets for Diabetes Mellitus

Abstract

Abbreviations

1 Introduction

2 Regulation of Glucose Homeostasis by GPCRs in the Central Nervous System

3 Regulation of Glucose Homeostasis by GPCRs for Peptides from Endocrine Pancreas

4 Regulation of Insulin Secretion by GPCRs

5 Regulation of Incretin Secretion by GPCRs

6 Regulation of Glucose Homeostasis by Orphan GPCRs

7 Summary

Acknowledgments

References

Chapter Two. Regulation of Glucose Homeostasis by GLP-1

Abstract

List of Abbreviations

1 Introduction

2 GLP-1 Biosynthesis, Secretion, and Degradation

3 Insulinotropic and Growth Factor Properties of GLP-1

4 Molecular Basis of GLP-1 Receptor Activation

5 Control of Pancreatic β-Cell Insulin Secretion by GLP-1

6 Altered GLP-1 Action in a Rodent Model of Insulin Resistance

7 Glucoregulatory Properties of GLP-1 Mediated by the Nervous System

8 GLP-1 Receptor Agonists

9 DPP-IV Inhibitors

10 GLP-1-Based Strategies for the Treatment of T2DM

11 Improved Glucoregulation After Bariatric Surgery

12 Safety Considerations for GLP-1-Based Therapeutics

13 Conclusion

Acknowledgments

References

Chapter Three. Physiology and Therapeutics of the Free Fatty Acid Receptor GPR40

Abstract

Abbreviations

1 Introduction

2 Molecular Cloning and Tissue Distribution of GPR40

3 Physiology of GPR40

4 Pharmacology of GPR40

5 Pathophysiology of GPR40

6 Conclusions

Acknowledgments

References

Chapter Four. Targeting GPR119 for the Potential Treatment of Type 2 Diabetes Mellitus

Abstract

Abbreviations

1 Introduction

2

Details

No. of pages:
536
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Print ISBN:
9780128001011
Electronic ISBN:
9780128002940

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal