Glioblastoma - 1st Edition - ISBN: 9780323476607, 9780323479745


1st Edition

Authors: Steven Brem Kalil Abdullah
eBook ISBN: 9780323479745
Hardcover ISBN: 9780323476607
Imprint: Elsevier
Published Date: 22nd September 2016
Page Count: 320

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Clinically focused and designed to provide a to-the-point overview, Glioblastoma, by Drs. Steven Brem and Kalil G. Abdullah, brings you up to date with increased understanding, new treatment protocols, and recent advances in the field. Written by contributing specialists who are global experts in their respective areas, this one-stop reference provides neurosurgeons, medical-and-radiation oncologists, neuro-oncologists, neuropathologists, internal medicine physicians, and researchers with a dependable source of information on current treatment options, tumor recurrence, and patient care.

Key Features

  • Evidence for current treatment options for de novo and recurrent glioblastoma, indications for local and topical therapies, immunotherapy, gene therapy, nanotherapy, small-molecule inhibition, electric tumor treating field stimulation, and antiangiogenic therapies and the role of Avastin.
  • Recent advances relating to tumor resection, such as stereotactic laser ablation, diffusion tensor imaging, and fluorescent markers.
  • Prognostic molecular and genetic markers and the impact of gene mutations on survival, as well as controversies relating to pseudo-progression.
  • Lessons learned from unsuccessful interventions, as well as the most promising aspects of future glioblastoma research and treatment.
  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Table of Contents

Part I: Disease Origins and Context

  1. The Story of Glioblastoma: History and Modern Correlates
  2. Epidemiology of Glioblastoma and Trends in Glioblastoma Survivorship
  3. The Molecular Pathogenesis of Glioblastoma
  4. Diagnostic, Prognostic, and Predictive Biomarkers for Adult and Pediatric Gliomas in Clinical Practice
  5. Multimodality Targeting of Glioma Cells

    Part II: Standards of Medical and Surgical Treatment
  6. Current Standards of Care in Glioblastoma Therapy
  7. Radiographic Detection and Advanced Imaging of Glioblastoma
  8. Principles and Tenets of Radiation Treatment in
  9. Chemotherapeutics and Their Efficacy
  10. Anti-angiogenic Therapy for Glioblastoma
  11. Recurrent Glioblastoma
  12. Principles of Surgical Treatment
  13. Awake Craniotomy for Glioblastoma
  14. Intraoperative Imaging of Glioblastoma
  15. Minimally Invasive Targeted Therapy for Glioblastoma Laser Interstitial Thermal Therapy (LITT)
  16. Local and Topical Treatment of Glioblastoma
  17. Tumor Treating Electric Fields for Glioblastoma

    Part III: Scientific Advances, Future Directions, and Socioeconomic Considerations
  18. Brain Plasticity and Reorganization Before, During, and After Glioma Reseaction
  19. Genetically modified T-cell therapy for glioblastoma
  20. Early Detection of Glioblastoma
  21. Health-Related Quality of Life and Neurocognitive Functioning after Glioblastoma Treatment
  22. Socioeconomics and Survival
  23. National and Global Economic Implications of Glioblastoma
  24. Lessons Learned: Clinical Trials and Other Interventions for Glioblastoma


No. of pages:
© Elsevier 2016
22nd September 2016
eBook ISBN:
Hardcover ISBN:

About the Authors

Steven Brem

Affiliations and Expertise

Chief, Neurosurgical Oncology, Co-Director, Penn Brain Tumor Center, Professor of Neurosurgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania

Kalil Abdullah

Affiliations and Expertise

Neurosurgery Resident, Department of Neurosurgery, The University of Pennsylvania Hospitals, Philadelphia, Pennsylvania