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Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies - 1st Edition - ISBN: 9780128215678

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies, Volume 14

1st Edition

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Editors: Tarik Massoud Ramasamy Paulmurugan
Hardcover ISBN: 9780128215678
Imprint: Academic Press
Published Date: 1st March 2021
Page Count: 350
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Table of Contents

1. Glioblastoma: Overview of biological hallmarks and molecular pathology
2. Contemporary drug treatment of glioblastoma

3. Investigational new drugs against glioblastoma

4. The hallmarks of anti-cancer drug resistance: An overview

5. Molecular mechanisms of innate and acquired temozolomide resistance in glioblastoma

6. Glioma stem cells and associated molecular mechanisms in glioblastoma chemoresistance

7. Molecular and cellular mechanims in recurrent glioblastoma chemoresistance

8. Intratumoral heterogeneity associated with glioblastoma drug response and resistance

9. The molecular and cellular effects of radiotherapy-induced microenvironment changes on potential chemoresistance in glioblastoma

10. Role of apoptosis, autophagy and the unfolded protein response in glioblastoma chemoresistance

11. Drug penetration through the BBB after radiotherapy: new approaches to bypass glioblastoma chemoresistance

12. Role of multi-drug resistance (ABC and solute carrier transporters) in glioblastoma chemoresistance

13. Glioblastoma cell-induced immunosuppression causing chemoresistance

14. Impediments to drug delivery in glioblastoma treatment: nove delivery strategies past the BBB

15. 3D in vitro models to study potentiation of gliobastoma resistance by hypoxia

16. On-chip analysis of glioblastoma chemoresistance

17. Chemoresistance mechanisms in mouse models of glioblastoma

18. Mechanism of glioblastoma chemoresistance to bevacizumab

19. Treament and resistance of glioblastoma to CAR-T cell immunotherapies

20. Therapeutic approaches to overcome temozolomide resistant glioblastoma

21. Metabolic strategies to overcome glioblastoma chemoresistance

22. Understanding signal transduction pathways to overcome targeted therapy resistance in glioblastoma

23. Therapies to target the molecular mechanisms of glioma stem cell resistance to chemotherapy

24. Vaccines to limit resistance against glioblastoma therapy

25. Role of BMP and TGF-β signaling in glioblastoma drug resistance and strategies for therapeutic intervention

26. Role of cell quiescence in glioblastoma drug resistance and strategies for therapeutic intervention

27. Role of IncRNAs in temozolomide-resistant glioblastoma

28. Role of mitochondiral reactive oxygen species release in glioblastoma drug resistance and strategies of therapeutic intervention

29. Role of miRNA therapy in pre-sensitizing glioblastoma cells to temozolomide treatment

30. Small molecules targeting p53 stabilization as a therapeutic strategy

31. Small molecules tartgeting misfolded mutants of p53 as a rescue strategy to improve chemotherapy

32. p53 supplementation as a targeted cancer gene therapy for glioblastoma


Description

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field.

Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.

Key Features

  • Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance
  • Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance
  • Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Readership

Cancer researchers, medical scientists, clinicians, graduate students. Neuro-oncologists


Details

No. of pages:
350
Language:
English
Copyright:
© Academic Press 2021
Published:
1st March 2021
Imprint:
Academic Press
Hardcover ISBN:
9780128215678

Ratings and Reviews


About the Editors

Tarik Massoud

Dr. Massoud has expertise in molecular imaging, translational cancer imaging, neuro-oncology, and applications and perspectives relevant to clinical cancer management of glioblastoma patients.

Affiliations and Expertise

Professor, Molecular Imaging Program at Stanford, and Department of Radiology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA

Ramasamy Paulmurugan

Dr. Paulmurugan has expertise in molecular imaging, pre-clinical cancer imaging, cancer biology, nanotechnology, and molecular biotechnology.

Affiliations and Expertise

Associate Professor, Molecular Imaging Program at Stanford, and Department of Radiology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA