Glioblastoma, Part II: Molecular Targets and Clinical Trials, An Issue of Neurosurgery Clinics of North America

1st Edition, Volume 32-2 - April 8, 2021
Editor: Linda M. Liau
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 1 3 0 5 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 1 3 0 6 - 8

This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by… Read more

Glioblastoma, Part II: Molecular Targets and Clinical Trials, An Issue of Neurosurgery Clinics of North America

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This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by the series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. Topics will include—but are not limited to—Pathology & Molecular Markers, Cellular States & Genetic Diversity in Glioblastoma, Mismatch Repair in Glioblastoma Resistance, Genetic Susceptibility in Brain Cancer, Pediatric Gliomas: Molecular Landscape & Emerging Targets, Molecularly Targeted Clinical Trials, Novel Radiation Sensitizers, Immunotherapy Checkpoint Inhibitors, Brain Tumor Vaccines, CAR T Cells, Oncolytic Virotherapy, Targeting Cancer Stem Cells, Therapeutic Delivery to CNS, Theranostics: Dual Modality PET Tracers, and Neuroimaging & Novel Response Assessments.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Molecular Considerations
Morphologic and Molecular Aspects of Glioblastomas
Key points
Introduction
Morphologic features of glioblastomas
Intraoperative consultation
Immunohistochemical evaluation
Molecular features and workup
DNA methylation classification
Summary
Metabolic Vulnerabilities in Brain Cancer
Key points
Introduction
The influence of nature and nurture on metabolism in gbm
The pentose phosphate pathway
Oxidative phosphorylation
Glutamine metabolism
Lipid metabolism
Hypoxia
Tumor microenvironment influence on glioblastoma metabolism: implications for experimental and translational studies
Therapeutic opportunities: unraveling metabolic dependencies in glioblastoma
Clinics care points
The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance
Key points
Introduction
Overview of the mismatch repair pathway and its relevance to glioblastoma multiforme
Detection of mismatch repair status in clinic
Mismatch repair status and immunotherapy response
Summary and future directions
Clinics care points
Pediatric Gliomas: Molecular Landscape and Emerging Targets
Key points
Current treatment strategies and prognosis
Molecular landscapes with promising therapies
Emerging targets and therapies under investigation
Clinical challenges and future directions
Summary
Clinics care points
Clinical Trials
Molecularly Targeted Clinical Trials
Key points
Introduction
Discussion
Summary
Clinics care points
Novel Radiation Approaches
Key points
Introduction
Dose and fractionation
Principles of target volume delineation
Particle therapy advances
Re-irradiation strategies
Future directions
Clinics care points
Brain Tumor Vaccines
Key points
Introduction
Peptide vaccines
Dendritic cell vaccines
Summary
Clinics care points
The Current Landscape of Immune Checkpoint Blockade in Glioblastoma
Key points
Background
The biological basis for immune checkpoint inhibition
Preclinical studies
Clinical studies
Multimodal immunotherapies in glioblastoma
Challenges of immune checkpoint inhibition therapy
Future directions
Summary
Clinics care points
CAR T Cells
Key points
Introduction
Chimeric antigen receptor T cells
Chimeric antigen receptor T cells delivery in the central nervous system
Tumor microenvironment in glioblastoma
Spatial and temporal glioblastoma heterogeneity
Targets of interest in glioblastoma
Chimeric antigen receptor T cells clinical trials for glioblastoma patients
Emergent clinical trials and future directions
Clinics care points
Immunovirotherapy for the Treatment of Glioblastoma and Other Malignant Gliomas
Key points
Introduction
Human oncolytic virus models
Zoonotic oncolytic virus models
Nononcolytic viral vectors for gene therapy or targeted drug delivery
Challenges, limitations, and future directions
Summary
Clinics care points
Targeting Glioma Stem Cells
Key points
Introduction
The history of the cancer stem cell hypothesis
Definitions/background
Discussion
Summary
Clinics care points
Therapeutic Delivery to Central Nervous System
Key points
Introduction
Challenges in treating glioblastoma
The blood-brain barrier
The blood-brain-tumor barrier
Strategies to overcome the blood-brain barrier/blood-brain-tumor barrier
Summary
Clinics care points