Although knowledge of the development and differentiation of glial cells has significantly increased in recent years, there are still many questions unanswered. The first section of the book is devoted to this very active topic and includes contributions on Schwann cells, oligodendrocytes, astroglia and microglia.
The second section of the book covers cellular interactions, the role they play on myelination and remyelination, how these interactions take place and the molecules involved.
The third section of this volume focuses on the interactions of neurons with glial cells and their role in brain function. Neuron-glia cross talk appears to be fundamental for synaptic transmission and several chapters in this section address this topic.
The topic of how glial cells react to brain injury and how they participate in neuroprotection and brain repair is covered in section four of this book. As our knowledge about the molecules involved in the regenerative properties of glia increases, new avenues are open for the use of genetically modified glia with therapeutic purposes.
The final section of the book is devoted to therapeutic approaches to tumours, viral and prion infections. Gene therapy is a promising approach for the treatment of gliomas, one of the most devastating forms of cancer. A chapter on prion diseases and microglia addresses a question of tremendous actuality, since prion diseases in cows is at this moment the major veterinary problem in Europe and has created a considerable social alarm.
List of contributors. Preface.
Glial cell development: origin and phenotype acquisition.
- Regulation of genes involved in Schwann cell development and differentiation (R. Mirsky, D.B. Parkinson, Z. Dong, C. Meier, E. Calle, A. Brennan, P. Topilko, B. Harris, G. Zoidl, H.J.S. Stewart, K.R. Jessen).
- Regulation of radial glia phenotype (P. LePrince, G. Chanas-Sacre).
- Astrocytic intermediate filaments: lessons from GFAP and vimentin knock-out mice (M. Pekny).
- Glial cells: a target for steroid hormones (R.C. Melcangi, V. Magnaghi, M. Galbiati, L. Martini).
Thyroid hormone role on nervous system morphogenesis (F.C.A. Carvalho, A. Gomes, F.R.S. Lima, A.G. Trentin, V. Moura Neto).
Early origin and colonization of the developing CNS by microglial precursors (M.A. Cuadros, J. Navascués).
- Microglia: its development and role as a neuropathology sensor (E.A. Ling, Y.K. Ng, C.H. Wu, C. Kaur).
- Colonisation of the human central nervous system by microglia: the roles of chemokines and vascular adhesion molecules (D. Male, P. Rezaie). Myelination, demyelination and remyelination.
- Astrocyte influences on oligodendrocyte progenitor migration (O. Schnädelbach, J.W. Fawcett).
- Tenascin-R as a regulator of CNS glial cell function (P. Pesheva, S. Gloor, R. Probstmeier).
- Process extension and myelin sheet formation in maturing oligodendrocytes (P.C. Buttery, C. ffrench-Constant).
- Recent advances in human perinatal white matter injury (S.A. Back).
- Models for demyelination (A. Van Der Goes, C.D. Dijkstra).
- The response of adult oligodendrocy
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- © Elsevier Science 2003
- 15th September 2003
- Elsevier Science
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Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Campus de Bellaterra, 08193 Barcelona, Spain
Instituto Cajal (CSIC), Avenida del Doctor Arce 37, 28002 Madrid, Spain