Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS), leading researchers to look at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS. This book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma.

Key Features

* Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols * Discusses new strategies for the prevention of neuronal injury in glaucoma patients * Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma


Neuroscientists, neurologists, opthalmologists, neuropharmacologists

Table of Contents

EPIDEMIOLOGY AND CLINICAL ASSESSMENT OF THE DISEASE 1. Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects C. Cedrone, R. Mancino, A. Cerulli, M. Cesareo and C. Nucci (Italy) 2. Predictive models to estimate the risk of glaucoma development and progression F.A. Medeiros and R.N. Weinreb (USA) 3. Intraocular pressure and central corneal thickness G. Manni, F. Oddone, V. Parisi, A. Tosto and M. Centofanti (Italy) 4. Angle-closure: risk factors, diagnosis and treatment N. Amerasinghe and T. Aung (Singapore) 5. Early diagnosis in glaucoma D.F. Garway-Heath (UK, Italy) 6. Monitoring glaucoma progression P. Brusini (Italy) ANATOMICAL AND FUNCTIONAL MONITORING 7. Standard automated perimetry and algorithms for monitoring glaucoma progressions G.L. Scuderi, M. Cesareo, A. Perdicchi and S.M. Recupero (Italy) 8. Short-wavelength automated perimetry and frequency-doubling technology perimetry in glaucoma P. Fogagnolo, L. Rossetti, S. Ranno, A. Ferreras and N. Orzalesi (Italy, Spain) 9. Scanning laser polarimetry and confocal scanning laser ophthalmoscopy: technical notes on their use in glaucoma F. Ferreri, P. Aragona and G. Ferreri (Italy) 10. The role of OCT in glaucoma management (Italy) 11. Functional laser Doppler flowmetry of the optic nerve: physiological aspects and clinical applications C.E. Riva and B. Falsini (Italy) 12. Advances in neuroimaging of the visual pathways and their use in glaucoma F.G. Garaci, V. Cozzolino, C. Nucci, F. Gaudiello, A. Ludovici, T. Lupattelli, R. Floris and G. Simonetti (Italy) CURRENT THERAPY 13. Primary open angle gl


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© 2008
Elsevier Science
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About the editors

Carlo Nucci

Affiliations and Expertise

University of Rome Tor Vergata, Italy

Neville Osborne

Affiliations and Expertise

Oxford University, UK

Giacinto Bagetta

Affiliations and Expertise

University of Calabria, Arcavata di Rende, Italy