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Gigantism and Acromegaly - 1st Edition - ISBN: 9780128145371

Gigantism and Acromegaly

1st Edition

Genetics, Diagnosis, and Treatment

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Editor: Constantine Stratakis
Paperback ISBN: 9780128145371
Imprint: Academic Press
Published Date: 1st February 2021
Page Count: 300
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Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as a recommended approaches to evaluation and management.

Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

Key Features

  • Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism
  • Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics
  • Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism


Endocrinologists with interest in pituitary tumors resulting in acromegaly and gigantism, pediatric endocrinologists and clinical geneticists, medical students and fellows

Table of Contents

1. History of the identification of gigantism and acromegaly by Patrick PETROSSIANS ((NEW chapter added from reviewer comments.)
2. Pathology of Pituitary Adenomas Secreting Growth Hormone by Sylvia Asa
3. Gigantism: Clinical Diagnosis and Description by Albert Beckers
4. Acromegaly: Clinical Diagnosis and Description by Ashley Grossman
5. Neuroimaging in gigantism and acromegaly by George Papadakis & Nick Patronas (NEW chapter added from reviewer comments.)
6. X-linked Acro-gigantism : by Giampaolo Trivellin
7. AIP Defects (Aryl hydrocarbon receptor interacting protein): by Laura Hernandez-Ramirez
8. 3-PAs : by Paraskevi Xekouki
9. CDKNIB (p27) defects by Natalia Pellegata and/or Marily Theodoropoulou
10. Multiple Endocrine Neoplasia (MENs) and pituitary tumors by Sunita Agarwal and/or S. Marx
11. GNAS, McCune-Albright syndrome, and GH-producing tumors by Anna Spada
12. Neurosurgical aspects of pit tumor secreting GH by Prashant Chittiboina
13. Irradiation and/or medical treatment of gigantism and acromegaly by Maria Fleseriu
14. Growth Hormone Releasing Hormone - producing and other tumors leading to overgrowth by Amit Tirosh and/or Maya Lodish
15. Increased GH secretion and non-pituitary tumors: is there an association? By Michael T. Collins ((NEW chapter added from reviewer comments.)


No. of pages:
© Academic Press 2021
1st February 2021
Academic Press
Paperback ISBN:

About the Editor

Constantine Stratakis

Dr. Stratakis was named Scientific Director of the NICHD in 2011, after serving as Acting Scientific Director of the NICHD since 2009. He received his M.D. and Doctor of Medical Sciences degrees from the National and Capodistrian University of Athens. He did predoctoral work at the Unit of Endocrinology, Department of Experimental Pharmacology at the same University, and at Hospital Cochin, Paris, France, before joining the Developmental Endocrinology Branch of the then National Institute of Child Health & Human Development, first as a student, and then as a postdoctoral fellow in 1988. In 1990, he continued his post-graduate medical education at Georgetown University Medical School, Washington, D.C., where he finished a residency in pediatrics and two fellowships in pediatric endocrinology (as part of the NICHD/Georgetown training program) and in medical genetics and clinical dysmorphology. He is Board certified in pediatrics, pediatric endocrinology, and medical genetics. Dr. Stratakis identified the genes for Carney complex and Carney-Stratakis syndrome, and other genetic defects leading to adrenal and other tumors, and he and his laboratory have published extensively in the fields of pediatric inherited disorders and cancer genetics, and on other pediatric adrenal and pituitary disorders. He is the author of more than 300 publications and has served as a regular reviewer. He is the author or co-author of nearly 600 publications, and has served as a regular reviewer for more than 100 journals, including Science, Nature Genetics, and the New England Journal of Medicine; he is currently Deputy Editor of the Journal of Clinical Endocrinology & Metabolism, the leading journal in Endocrinology. He has been the recipient of the 1999 Pharmacia-Endocrine Society Award for Excellence in Published Clinical Research, and NIH Merit Awards, and named Visiting Professor in academic centers around the world. In 2009, he was awarded the Ernst Oppenheimer Award of the Endocrine Society.

Affiliations and Expertise

Scientific Director, Chief, Section on Endocrinology and Genetics, National Institute of Child Health and Human Development, NIH, Bethesda, MD

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