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1. The structural organization of the cytoskeleton of Giardia
2. Microtubule organelles in Giardia
3. Recent Advances in Functional Research in Giardia duodenalis
4. Proteomics and transcriptomics of Giardia-epithelial cell-interactions
5. Pathogenesis and post-infectious complications of giardiasis
6. Drug Resistance in Giardia: Mechanisms and Alternative Treatments for Giardiasis
Giardia and Giardiasis Volume 107-Part B, in the Advances in Parasitology series, is dedicated to aspects of cytoskeletal structure of this parasite with an emphasis on insights of new components and their function in trophozoites. Further, microtubule function and its critical involvement in motility, attachment, mitosis and cell division as well as in transitions between developmental stages are reviewed. Also a comprehensive revision in the progress of tools to explore and understand the functional biology of Giardia, its coding and non-coding genes, features and cellular and molecular biology is contained in this volume. Additionally, an exciting perspective on the interactions between Giardia and intestinal epithelial cell by reviewing transcriptomic and proteomic investigations is included along with a state-of-the art of the understanding pathophysiology of giardiasis and of how Giardia can cause post-infectious and extra-intestinal complications. A complete review of current knowledge including commonly prescribed drugs, causes of therapeutic fails, drug resistance mechanisms, strategies for the discovery of new agents for alternative drug therapies is covered.
- Informs and updates on all the latest developments in the field of parasitology
- Includes medical studies of parasites of major influence
- Features reviews of more traditional areas, such as zoology, taxonomy and life history which help to shape current thinking and applications
PhD students, professors, scientists, health workers, government officers, and policy makers at various levels
- © Academic Press 2020
- 1st March 2020
- Academic Press
- Hardcover ISBN:
Dr. M. Guadalupe Ortega Pierres´ group carries out studies on the protozoan parasite Giardia duodenalis which is a common intestinal parasite in humans worldwide that causes giardiasis. This infection is one of the most frequently diagnosed waterborne diseases and is considered a major public health problem particularly in developing countries. Her work includes the study of basic aspects of host-pathogen interaction. In particular her group is interested in identifying parasite molecules which are expressed and secreted during the interaction of parasite with epithelial cells such as proteases, VSPs and enolase. Also her group has addressed the analysis of the damage caused by these virulence factors in epithelial cells and at the intestinal epithelium in order to understand at the molecular level the pathogenic mechanisms in experimental giardiasis. These studies will define parasite components involved in epithelial cell damage and these may allow the design of new strategies for the control and prevention of giardiasis both in humans and in animals. Her group has also approached the study of the mechanisms involved in the induction of resistance to drugs commonly used in the treatment of giardiasis. They have approached this by the generation of resistant G. duodenalis strains and clones to different drugs and these have been used to identified both, mechanisms and molecules that are involved, particularly, in the resistance to albendazole. These studies will allow understanding the processes involved in the induction of drug resistance in Giardia and will contribute to develop other useful methods for the treatment of the giardiasis.
Professor, Department of Genetics and Molecular Biology, Centro de Investigacion y de Estudios Avanzados IPN, Mexico