Germfree Life And Gnotobiology

Germfree Life And Gnotobiology

1st Edition - January 1, 1963

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  • Author: Thomas Luckey
  • eBook ISBN: 9780323147101

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Germfree Life and Gnotobiology focuses on the theory and general aspects of germfree research and gnotobiology. Using a phylogenetic approach, the book provides a summary of germfree work in all phyla, from bacteria and viruses to protozoans and invertebrates. It characterizes germfree vertebrates based on data on morphology, biochemistry, nutrition, serology, and physiology. This book is organized into six chapters and begins with an overview of germfree life and gnotobiology, including biological isolation as the basis of germfree life, germfree conditions in nature, and the biological significance of germfree research. A section is devoted to nomenclature and terminology. The chapters on methods and nutrition are sufficiently detailed to serve as guides for experimental work. The book concludes with a chapter on exploratory research that explores the inoculation of germfree animals with known kinds of microorganisms. Terms have been introduced to describe concepts and provide precise communication. This book is a valuable source of information for scientists and researchers engaged in germfree research as a biological tool.

Table of Contents

  • Preface


    1 Theory and General Aspects of Germfree Life and Gnotobiology

    Biological Isolation as the Basis of Germfree Life

    Germfree Conditions in Nature

    Essential Elements in Germfree Research

    Biological Significance of Germfree Research

    Relationship to Other Enclosed Systems


    Nomenclature and Terminology


    2 Phylogenetic Development of Germfree Research

    Early Concepts

    Sterile Plants

    Germfree Culture of Tissues

    Germfree Invertebrates

    Germfree Vertebrates


    3 Germfree Animal Techniques



    Obtaining Germfree Animals

    Microbial Testing

    Summary of Methods

    Production, Maintenance, and Repair Problems



    4 Nutrition of Germfree Animals

    General Considerations

    Intestinal Synthesis Theory

    Diet and Microorganisms

    Diet Changes during Sterilization

    The First Colony of Germfree Mammals

    Diets and Feeding

    Nutritional Requirements


    5 Characteristics of Germfree Animals


    General Characteristics

    Systems, Organs, and Tissues

    Defense Mechanisms

    Abnormalities in Form and Function

    Reparative Processes


    6 Gnotophoric Animals



    Bacteria-Host Gnotobiotes

    Virus-Host Gnotobiotes

    Protozoa-Host Gnotobiotes

    Invertebrate-Host Gnotobiotes





    I. Chronology

    II. Glossary

    III. Diets for Germfree Animals


Product details

  • No. of pages: 526
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9780323147101

About the Author

Thomas Luckey

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