
Germfree Life And Gnotobiology
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Germfree Life and Gnotobiology focuses on the theory and general aspects of germfree research and gnotobiology. Using a phylogenetic approach, the book provides a summary of germfree work in all phyla, from bacteria and viruses to protozoans and invertebrates. It characterizes germfree vertebrates based on data on morphology, biochemistry, nutrition, serology, and physiology. This book is organized into six chapters and begins with an overview of germfree life and gnotobiology, including biological isolation as the basis of germfree life, germfree conditions in nature, and the biological significance of germfree research. A section is devoted to nomenclature and terminology. The chapters on methods and nutrition are sufficiently detailed to serve as guides for experimental work. The book concludes with a chapter on exploratory research that explores the inoculation of germfree animals with known kinds of microorganisms. Terms have been introduced to describe concepts and provide precise communication. This book is a valuable source of information for scientists and researchers engaged in germfree research as a biological tool.
Table of Contents
Preface
Acknowledgments
1 Theory and General Aspects of Germfree Life and Gnotobiology
Biological Isolation as the Basis of Germfree Life
Germfree Conditions in Nature
Essential Elements in Germfree Research
Biological Significance of Germfree Research
Relationship to Other Enclosed Systems
Gnotobiology
Nomenclature and Terminology
Summary
2 Phylogenetic Development of Germfree Research
Early Concepts
Sterile Plants
Germfree Culture of Tissues
Germfree Invertebrates
Germfree Vertebrates
Summary
3 Germfree Animal Techniques
Cages
Sterilization
Obtaining Germfree Animals
Microbial Testing
Summary of Methods
Production, Maintenance, and Repair Problems
Decontamination
Summary
4 Nutrition of Germfree Animals
General Considerations
Intestinal Synthesis Theory
Diet and Microorganisms
Diet Changes during Sterilization
The First Colony of Germfree Mammals
Diets and Feeding
Nutritional Requirements
Summary
5 Characteristics of Germfree Animals
Introduction
General Characteristics
Systems, Organs, and Tissues
Defense Mechanisms
Abnormalities in Form and Function
Reparative Processes
Summary
6 Gnotophoric Animals
Introduction
Methods
Bacteria-Host Gnotobiotes
Virus-Host Gnotobiotes
Protozoa-Host Gnotobiotes
Invertebrate-Host Gnotobiotes
Conventionalization
Summary
References
Appendices
I. Chronology
II. Glossary
III. Diets for Germfree Animals
Index
Product details
- No. of pages: 526
- Language: English
- Copyright: © Academic Press 1963
- Published: January 1, 1963
- Imprint: Academic Press
- eBook ISBN: 9780323147101
About the Author
Thomas Luckey
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