Genomic Regulatory Systems

Genomic Regulatory Systems

In Development and Evolution

1st Edition - January 11, 2001

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  • Author: Eric Davidson
  • eBook ISBN: 9780080525594

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The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.

Key Features

* Contents Include
* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans


Students and professionals in biology, cell biology, and molecular biology. Also, any person with a general interest in evolution.

Table of Contents

  • Preface

    1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution

    The Regulatory Apparatus Encoded in the DNA

    The Genes and Gene Regulatory Components of Animal Genomes

    Overview of Regulatory Architecture

    Gene Regulatory Functions in Development

    The Regulatory Demands of Development

    Pattern Formation

    Terminal Differentiation

    Genomic Regulatory Sequence and the Evolution of Morphological Features

    Regulatory Evolution, and Evolution in General

    Bilaterian Phylogeny

    2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression

    Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events

    Spatial Repression in cis-Regulatory specification

    Two Very Different Examples of Similar Import

    cis-Regulatory Design for Autonomous Modular Function

    The Generality of Repression

    Downstream of Specification

    Some Examples

    At the Beginning of Embryogenesis

    Polyfunctional Downstream Modules

    The "Power" of the cis-Regulatory Module

    Diverse cis-Regulatory Outputs from a Simple Input

    Direct Integration of Noncoincident Spatial Inputs

    A cis-Regulatory Logic Device

    3. Regulation of Direct Cell-Type Specification in Early Development

    The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes

    Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo

    The Definitive Territories of the Embryo

    Early Transcriptional Activation of Cell Type-specific Genes

    Initial Regulatory Processes

    Multiple Inputs for Endomesoderm Specification

    Regulatory Mechanisms Controlling Specification in Ascidian Embryos

    Territorial Specification

    Mechanisms and Pathways in Mesoderm Specification

    Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification

    Endoderm Specification

    The Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification

    Short Summary: Quality of Type 1 Regulatory Networks

    4. The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts

    The Evolutionary Significance of "Pattern Formation"

    The First Step: Transcriptional Definition of the Domain of the Body Part

    Morphological Pieces and Regulatory Subpatterns

    Heart Parts

    Forelimb and Hindlimb Buds

    Transcriptional Domains in the Gut Endoderm

    Patterns in the Developing Hindbrain

    Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs

    Glimpses of How It Works

    Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs

    Patterning the Heart Progenitor Field in Drosophila

    Encoding Hindbrain Regulatory Patterns

    The Role of Signaling

    The Last Routines: Calling in Differentiation Programs

    Specification of Peripheral Nervous System Elements in the Drosophila Wing

    Installation of Cell Type-specific Differentiation Programs in the Pituitary

    Concluding Remark

    5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

    Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions

    hox Gene Functions and Cooptions of the hox Cluster Patterning System

    A Specific Case of A/P Patterning: How a box Gene Does its Job

    Evolutionary Changes in box Gene Expression in the Arthropods

    Off the A/P Axis

    Colinear Expression of box Genes in the Somatocoels of Sea Urchin Larvae

    Small Changes

    Evolutionary Origins of Body Parts

    Polarity in Body Part Evolution

    The Case of pax6 and Some Other Amazing Examples

    Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks



Product details

  • No. of pages: 261
  • Language: English
  • Copyright: © Academic Press 2001
  • Published: January 11, 2001
  • Imprint: Academic Press
  • eBook ISBN: 9780080525594

About the Author

Eric Davidson

Eric Davidson
Isabelle S. Peter is Assistant Research Professor and Eric H. Davidson is Norman Chandler Professor of Cell Biology in the Division of Biology and Biological Engineering at the California Institute of Technology, Pasadena, California. Over the last seven years they have co-authored a series of works on experimental, conceptual and computational analyses of developmental gene regulatory networks, including their evolutionary significance. The discussions and conceptual explorations occasioned by this collaboration produced the new synthetic views encompassed in this book, building on decades of earlier work summarized in the 2001 and 2006 Academic Press books by Eric H. Davidson.

Affiliations and Expertise

Norman Chandler Professor of Cell Biology, California Institute of Technology, Pasadena, CA, USA

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