Table of Contents

Foreword

Preface

Acknowledgments

Abbreviations

Contributors

Volume 1

Chapter 1. The Human Genome: A Window on Human Genetics, Biology, and Medicine

Introduction

The Human Genome

Variation in the Human Genome

Expression of the Human genome

Genes, Genomes, and Disease

From Genomes to Personalized Medicine

Conclusion

References

Chapter 2. Mapping the Functional Genome: The ENCODE and Roadmap Epigenomics Projects

Introduction

General Organization and Directives for ENCODE and Roadmap

Scientific Parameters and Elements of the Projects

Challenges and the Future

References

Recommended Resources

Chapter 3. Population Perspectives on Genome Variation and Complex Disease

Introduction

Why Study Complex Disease in Populations?

What can be Studied? Phenotypes in Population Genomic Studies of Complex Disease

Human Population History and the Reservoir of Human Genome Sequence Variation

Human Genomes Contain Footprints of Human Evolution and the Human Past

Conclusions

References

Chapter 4. Gene–Environment Interactions: Eco-Genetics and Toxicogenomics

Introduction

Eco-Genetics

Methods to Study G × E Interactions

Nutrigenomics

Pathogens and Host Susceptibility or Resistance Gene Variants

Inhaled Chemical Air Pollutants and Allergens and Sensitizing Agents

Examples of Risk Factors

Epigenomics and the Environment

Effects on Protein Folding

Toxicogenomics and Predictive Toxicology

Will Personalized Genomic Risk Profiles Motivate PEOPLE to Adopt More Healthful Behaviors?

Future Prospects: Balancing the Gxe Equation

References

Recommended Resources

Chapter 5. Systems Biology and Systems Medicine

Introduction

Details

No. of pages:
1350
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780123822277
Electronic ISBN:
9780123822284

Awards

BMA Medical Book Award 2013: Medicine - Highly Commended, British Medical Association