Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease

1st Edition - April 7, 2020

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  • Editors: Diego Forero, George Patrinos
  • eBook ISBN: 9780128178201
  • Paperback ISBN: 9780128178195

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Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.

Key Features

  • Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders
  • Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery


Active researchers, basic and translational scientists, clinicians, postgraduates, and students in the areas of genetics, human genomics, pathology, cellular biology, organismal biology, molecular biology, biochemistry, and bioinformatics

Table of Contents

  • 1. Impact of Genome Plasticity on Health and Disease

    Section I. Plasticity of the Human Genome
    2. Overview of the Human Genome
    3. Methods for Epigenomic Analyses: DNA Methylation
    4. Genomic Databases
    5. Genomic Variability: Germline, Somatic and de novo Variants
    6. Founder Variations in Isolated Populations
    7. DNA Methylation
    8. Chromatin, Histones and Histone Modifications in Health and Diseases
    9. Networks of Transcription Factors
    10. Centromere and Telomere Dynamics in Humans

    Section II. Human Genome Plasticity and Diseases
    11. Genome Plasticity and Cardiovascular Diseases
    12. Genome Plasticity and Neuropsychiatric Disorders
    13. Genome Plasticity and Endocrine Diseases
    14. Implications of Genome Plasticity for Drug Development

Product details

  • No. of pages: 288
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: April 7, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128178201
  • Paperback ISBN: 9780128178195

About the Series Volume Editors

Diego Forero

Professor Forero is medical doctor, graduated from the National University of Colombia and did his PhD in Biomedical Sciences at the University of Antwerp (Belgium). Dr. Forero is Full Professor at the School of Medicine of the Universidad Antonio Nariño (Bogotá, Colombia), being the current leader of the Biomedical Sciences Research Group, Director of the Neuropsychiatric Genetics Laboratory and Director of the PhD Program in Health Sciences. He has led several research projects in molecular genetics of neurological and psychiatric disorders, in collaboration with national and international research groups. Dr Forero has authored publications in international scientific journals and books (cumulative impact factor of 223.267, h index: 22). He has been Associate Editor of BMC Research Notes, member of the editorial board of 3 international scientific journals and peer reviewer for 69 international scientific journals.

Affiliations and Expertise

Full Professor; Director, Laboratory of Neuropsychiatric Genetics; Director, PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia

George Patrinos

George Patrinos is Professor of Pharmacogenomics at the University of Patras School of Health Sciences (Department of Pharmacy) in Patras, Greece with Adjunct positions in Rotterdam, the Netherlands and Al-Ain, United Arab Emirates. His research interests span the fields of pharmacogenomics and personalised medicine, focused on psychiatric diseases and hemoglobinopathies, the implementation of genomics into healthcare, particularly for health systems in developing countries, the development of genomic databases and web-based translational tools for personalised medicine and the application of genomics in public health. George Patrinos has published more than 270 scientific papers in peer reviewed journals on topics related to genetics, genomic medicine, pharmacogenomics, molecular diagnostics, and social and economic evaluation for genomic medicine. He is also the editor of several textbooks published by Elsevier/Academic Press, including the renowned textbook "Molecular Diagnostics", published by Elsevier now in its third edition. He serves as Editor-In-Chief and Communicating and Associate Editor for several high impact scientific journals and he is co-organizer of the international meeting series “Golden Helix Conferences”.

Affiliations and Expertise

Professor, Department of Pharmacy, University of Patras School of Health Sciences, Patras, Greece; United Arab Emirates University, College of Medicine and Health Sciences, Department of Pathology, Al-Ain, UAE, United Arab Emirates University, Zayed Center of Health Sciences, Al-Ain, UAE and Erasmus University Medical Center, School of Medicine and Health Sciences, Department of Pathology – Bioinformatics Unit, Rotterdam, The Netherlands

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  • TaliaWegman Tue Jun 30 2020

    Excelent book

    A great book with information about whats is new in the genomic world