Genetics of Stem Cells, Volume 111

1st Edition

Part A

Print ISBN: 9780123984593
eBook ISBN: 9780124017467
Imprint: Academic Press
Published Date: 6th September 2012
Page Count: 384
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This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine

Table of Contents

  • Contributors
  • Preface
  • Chapter 1 Generation of Induced Pluripotent Stem Cells from Somatic Cells
    • I Generation of iPSCs
    • II Methods of Delivering Transcription Factors into Cells
    • III Nongenetic Approaches for Reprogramming
    • IV Generation of Human iPSCs from Different Somatic Cell Types
    • V Characterization of iPSCs
    • VI Conclusion

  • Chapter 2 Induced Pluripotent Cells in Cardiovascular Biology
    • I Introduction
    • II Non-iPS-Cell-Based Therapies and Their Limitations
    • III Therapeutic Cloning and Embryonic Stem Cells
    • IV Induced Pluripotent Stem cells from Differentiated Somatic Cells
    • V Cardiovascular Lineage Differentiation of iPS Cells

  • Chapter 3 Reprogramming of Somatic Cells
    • I Introduction
    • II Reprogramming of Somatic Cells into Pluripotent Stem Cells
    • III Future Perspectives

  • Chapter 4 Induction of Somatic Cell Reprogramming Using the MicroRNA miR-302
    • I Introduction
    • II Mechanism of Reprogramming
    • III Role of miR-302 in Early Embryogenesis
    • IV Dual Role of miR-302: Reprogramming Effector and Tumor Suppressor
    • V Balancing Stem Cell Tumorigenicity and Senescence
    • VI Conclusion

  • Chapter 5 From Ontogenesis to Regeneration
    • I Regeneration: From Urodeles and Teleosts to Mammals
    • II To the “Heart” of the Problem
    • III Lessons from Development
    • IV Understanding the Stem Cell “Niche” and Its Roles
    • V Recreating the Niche: The Importance of 3D Models
    • VI Cardiac Cell Therapy: The Era of Clinical Trials
    • VII Concluding Remarks

  • Chapter 6 Roles of MicroRNAs and Myocardial Cell Differentiation
    • I Introduction
    • II Myocardial Differentiation of ES Cells and miRNA
    • III Somatic Cell Rep


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© Academic Press 2012
Academic Press
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Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal