Genetics of Stem Cells

Genetics of Stem Cells

Part A

1st Edition - September 6, 2012

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  • Editor: Yaoliang Tang
  • eBook ISBN: 9780124017467
  • Hardcover ISBN: 9780123984593

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Description

This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine

Table of Contents

    • Contributors
    • Preface
    • Chapter 1 Generation of Induced Pluripotent Stem Cells from Somatic Cells
      • I Generation of iPSCs
      • II Methods of Delivering Transcription Factors into Cells
      • III Nongenetic Approaches for Reprogramming
      • IV Generation of Human iPSCs from Different Somatic Cell Types
      • V Characterization of iPSCs
      • VI Conclusion
    • Chapter 2 Induced Pluripotent Cells in Cardiovascular Biology
      • I Introduction
      • II Non-iPS-Cell-Based Therapies and Their Limitations
      • III Therapeutic Cloning and Embryonic Stem Cells
      • IV Induced Pluripotent Stem cells from Differentiated Somatic Cells
      • V Cardiovascular Lineage Differentiation of iPS Cells
    • Chapter 3 Reprogramming of Somatic Cells
      • I Introduction
      • II Reprogramming of Somatic Cells into Pluripotent Stem Cells
      • III Future Perspectives
    • Chapter 4 Induction of Somatic Cell Reprogramming Using the MicroRNA miR-302
      • I Introduction
      • II Mechanism of Reprogramming
      • III Role of miR-302 in Early Embryogenesis
      • IV Dual Role of miR-302: Reprogramming Effector and Tumor Suppressor
      • V Balancing Stem Cell Tumorigenicity and Senescence
      • VI Conclusion
    • Chapter 5 From Ontogenesis to Regeneration
      • I Regeneration: From Urodeles and Teleosts to Mammals
      • II To the “Heart” of the Problem
      • III Lessons from Development
      • IV Understanding the Stem Cell “Niche” and Its Roles
      • V Recreating the Niche: The Importance of 3D Models
      • VI Cardiac Cell Therapy: The Era of Clinical Trials
      • VII Concluding Remarks
    • Chapter 6 Roles of MicroRNAs and Myocardial Cell Differentiation
      • I Introduction
      • II Myocardial Differentiation of ES Cells and miRNA
      • III Somatic Cell Reprogramming and miRNA
      • IV Heart Disease and MicroRNAs
      • V Conclusion
    • Chapter 7 Wnt Signaling and Cardiac Differentiation
      • I Introduction
      • II Wnt Signaling
      • III Wnt Proteins and Cardiogenesis
      • IV Concluding Remarks
    • Chapter 8 Cross Talk Between the Notch Signaling and Noncoding RNA on the Fate of Stem Cells
      • I Introduction
      • II Direct Role of Notch Signaling in Stem Cell Maintenance and Differentiation
      • III Cross Talk Between MicroRNA and Notch Signal on Stem Cell Fate (Fig. 2)
      • IV Epigenetic Regulation of Stem Cell Fate via Notch Signaling
      • V Conclusions
    • Chapter 9 Myocardial Regeneration
      • I Introduction
      • II Is There Cardiomyocyte Regeneration from Endogenous CPCs Post-MI?
      • III Paracrine Effects of Transplanted Cells in the Injured Heart
      • IV IGF + HGF Administration Can Activate In Situ CPCs to Generate Cardiomyocytes
      • V Do Transplanted BM-Derived and/or Transplanted or In Situ CPCs Transdifferentiate into Cardiomyocytes and Vascular Cells?
      • VI Do CDCs and/or MSCs Stimulate Endogenous CPCs to Regenerate Cardiomyocytes and Vascular Cells?
      • VII Can Differentiated Cardiomyocytes Be Induced to Dedifferentiate and Reenter the Cell Cycle?
      • VIII Conclusions and Future Perspectives
    • Chapter 10 Role of GATA-4 in Differentiation and Survival of Bone Marrow Mesenchymal Stem Cells
      • I Introduction
      • II Cytotherapy in Myocardial Infarction
      • III Genetic Engineering of MSCs with Cytoprotective Factors
      • IV Conclusions
    • Chapter 11 Progenitor Cell Mobilization and Recruitment: SDF-1, CXCR4, α4-integrin, and c-kit
      • I Introduction
      • II Progenitor Cell Mobilization
      • III Progenitor Cell Recruitment and Retention
      • IV Therapeutic Implications
      • V Summary
    • Chapter 12 Genetically Manipulated Progenitor/Stem Cells Restore Function to the Infarcted Heart Via the SDF-1α/CXCR4 Signaling Pathway
      • I Importance of SDF-1α and CXCR4 Interaction in Ischemic Hearts
      • II Role of SDF-1α/CXCR4 as Therapeutic Targets in Heart Disease
      • III SDF-1α/CXCR4 as Therapeutic Targets in Vascular Diseases
      • IV Role of SDF-1α/CXCR4 in Cell-Based Therapy
      • V Genetically Manipulated Cell Patch for Repair of Infarcted Myocardium
      • VI Conclusions
    • Chapter 13 Genetic Modification of Stem Cells for Cardiac, Diabetic, and Hemophilia Transplantation Therapies
      • I Introduction
      • II Genetic Engineering
      • III The Application of Genetic Modification of Stem Cells
    • Chapter 14 Role of Heat Shock Proteins in Stem Cell Behavior
      • I Introduction
      • II Hsps in the Modulation of SC Self-Renewal
      • III Expression Profiles of Hsp in Differentiated SCs
      • IV Roles of Hsps in Tissue Genesis
      • V Protective Effects of Hsps in Transplanted SCs
      • VI Roles of Hsps in SC Aging
      • VII Conclusions
    • Chapter 15 Preconditioning Approach in Stem Cell Therapy for the Treatment of Infarcted Heart
      • I Introduction
      • II Stem Cell Therapy and the Heart
      • III Stem Cell Survival: Major Determinant of Efficacy of Stem Cell Therapy
      • IV Preconditioning: A Strategy to “Prime” the Cells for Improved Survival Under Stress
      • V Conclusions
    • Index

Product details

  • No. of pages: 384
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: September 6, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780124017467
  • Hardcover ISBN: 9780123984593

About the Serial Volume Editor

Yaoliang Tang

Affiliations and Expertise

MD, Ph.D, FAHA, Vascular Biology Center & Department of Medicine, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA

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