Table of Contents


List of Contributors

Part I: General Background to Bone Biology

Chapter 1. Biology of Bone and Cartilage

I. Introduction

II. Osteoclasts

III. Osteoblasts

IV. Cartilage


Chapter 2. Overview of Bone Structure and Strength

I. Introduction

II. Bone Biomechanics and the Determinants of Whole Bone Strength

III. Contribution of Bone Geometry to Bone Strength

IV. Age-Related Changes in Trabecular and Cortical Bone Microarchitecture

V. Contribution of Bone Microarchitecture to Bone Strength

VI. Contribution of Bone Structure to Fracture Risk in Humans

VII. Summary


Chapter 3. Overview of Joint and Cartilage Biology

I. Introduction

II. Joint Development

III. Joint Anatomy

IV. Joint Homeostasis

V. Joint Disease

VI. Joint Repair


Chapter 4. Integrating Endocrine and Paracrine Influences on Bone: Lessons from Parathyroid Hormone and Parathyroid Hormone-related Protein

I. Bone Remodeling and Modeling

II. Parathyroid Hormone (PTH) and Parathyroid Hormone-Related Protein (PTHrP)

III. PTHrP in Bone: Production in Osteoblasts

IV. PTHrP Function in Bone: Lessons from PTHrP Null Mice

V. Anabolic Actions of PTH and PTHrP

VI. Endocrine PTH, Paracrine PTHrP: Relationships in Development and Postnatal Life

VII. Growth Factors in the Local Actions of PTH and PTHrP

VIII. Are Osteoclasts Involved in the Anabolic Action of PTH?

IX. GP130 Cytokines as Agents of Local Control of PTH Action

X. Sclerostin as a Local Factor promoting PTH Action

XI. Other Influences of PTH/PTHrP on Bone Through the Bone Marrow Microenvironment

XII. The PTH–PTHrP Relationship in Vasculature and Bone

XIII. Conclusion


Chapter 5. Energy Home


No. of pages:
© 2013
Academic Press
eBook ISBN:
Print ISBN:

About the editors

Rajesh Thakker

Affiliations and Expertise

May Professor of Medicine, Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, UK

Michael Whyte

Affiliations and Expertise

Professor of Medicine, Pediatrics, and Genetics, Washington University in St. Louis School of Medicine; Medical-Scientific Director, Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St. Louis, USA

John Eisman

Affiliations and Expertise

Director of Bone Research Program, Garvan Institute of Medical Research, Professor of Medicine, University of New South Wales, Australia

Takashi Igarashi

Affiliations and Expertise

Department of Pediatrics, Faculty of Medicine, The University of Tokyo, Mejirodai, Japan; past president of ISN and Japanese Pediatric Association


"With the aims of identifying and analyzing the genetic basis of bone disorders in humans and of demonstrating the utility of mouse models, this volume presents 36 chapters that are inter-related, yet self-contained, with some overlap. Coverage is comprehensive."--Reference and Research, April 2013
"The last ten years have witnessed an explosion in genomics and through its application to bone biology, the identification of novel potential targets for therapeutic interventions in bone diseases, such as osteoporosis. This textbook is therefore very timely and integrates a review of bone biology with the genetics of bone and joint disorders, parathyroid and related disorders, and vitamin D and renal diseases.
The section on osteoporosis genes identified by genome-wide association studies is particularly useful and effectively summarises a subset of the at least 56 loci that have shown a robust association with BMD at genome-wide significant level and have been replicated. Although these genes explain only about 4% of the variation in BMD and cannot be used to improve fracture risk prediction, they have pinpointed many factors in critical molecular pathways in bone that provide promising candidates for novel therapeutic interventions.
The section on genetic disorders of vitamin D synthesis and action elegantly shows how the study of affected children with 1a-hydroxylase deficiency and hereditary vitamin D resistant rickets continues to provide a more complete understanding of the biological role of 1,25(OH)2D in vivo.
In conclusion, if you want to find one place to "bone up" on the genetics of skeletal disease, this is the book for you!"--Professor Peter R. Ebeling MD FRACP,
The University of Melbourne, Melbourne, Australia
"This book brings together the world’s most expert bone biologists, clinicians and geneticists to provide a cutting-edge review of bo