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Genetics of Bacterial Diversity - 1st Edition - ISBN: 9780123555748, 9781483273556

Genetics of Bacterial Diversity

1st Edition

Editors: David A. Hopwood Keith F. Chater
eBook ISBN: 9781483273556
Imprint: Academic Press
Published Date: 1st December 1988
Page Count: 466
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Genetics of Bacterial Diversity focuses on the rapidly developing field of ""non-K-12"" bacterial genetics that is largely outside the scope of other texts. The book begins with an introductory chapter that outlines the phylogenetic relationships of bacteria and the range of metabolic, behavioral, and developmental phenomena displayed by them. Two chapters then review the genetic processes found in bacteria generally, and discuss a range of genetic techniques used to analyze the various special systems described in the body of the book, respectively. Subsequent chapters deal with various special metabolic capabilities characteristic of certain groups of bacteria (light production, photosynthesis, nitrogen fixation, antibiotic production, degradation of aromatic compounds and mercury resistance); developmental processes of cell-cycle associated motility, sporulation, and specialized colonial behavior; four components of bacterial pathogenicity for animals; and pathogenic and symbiotic interactions of bacteria with higher plants. The final chapter explains some of the concepts and the progress being made in the application of population genetics to bacteria. This book may be of interest to microbiologists wishing to catch up on the genetic basis of some of the classical phenomena of bacteriology, and geneticists unfamiliar with some of the things that bacteria can accomplish.

Table of Contents



Section I Introductory Chapters: the Diversity of Bacteria and of Bacterial Genetics

Chapter 1 Bacterial Diversity: the Range of Interesting Things that Bacteria Do

I. Introduction

II. Ecological Niches

III. Towards a Phylogeny of Bacteria

IV. Reinvention throughout the Phylogenetic Tree

V. Some Unexpected Attributes of Bacteria

VI. Conclusion



Chapter 2 Diversity of Bacterial Genetics

I. Introduction

II. The Prokaryotic Genome

III. Transfer of Chromosomal DNA between Bacteria

IV. Gene Expression

V. Gene-, Pathway- and Regulon-Specific Regulatory Mechanisms

VI. Differences between Prokaryote and Eukaryote Genetics

VII. Closing Remarks



Chapter 3 Cloning and Molecular Analysis of Bacterial Genes

I. Introduction

II. Cloning Bacterial DNA

III. Mutagenesis with Cloned DNA

IV. Biochemical Procedures that Exploit Cloned DNA

V. Current Limitations and Possibilities


Section II Specialized Metabolic Capabilities of Bacteria

Chapter 4 Regulation of Luminescence in Marine Bacteria

I. Introduction

II. Organization and Function of lux Genes

III. Regulation of lux Expression

IV. Luminescence Variation

V. Conclusions



Chapter 5 Photosynthesis in Rhodospirillaceae

I. Introduction

II. Structure-Function of the Photosynthetic Apparatus

III. Protein Components of the Photosynthetic Apparatus

IV. Photosynthetic Apparatus Genes

V. In Vitro Mutagenesis Studies

VI. Genetic Engineering in Reaction Centers


Chapter 6 The Genetics of Nitrogen Fixation

I. The Diversity of Nitrogen-Fixing Bacteria

II. The nif Genes of Klebsiella pneumoniae

III. The Assembly of Active Nitrogenase

IV. The Biochemistry and Physiology of Nitrogenase

V. The Three Nitrogenases of Azotobacter

VI. nif Genes in Other Organisms

VII. Rearrangement of nif Genes in Anabaena

VIII. Regulation of Expression of nif Genes

IX. Concluding Remarks



Chapter 7 Antibiotic Biosynthesis in Streptomyces

I. Introduction to Streptomyces Biology

II. Antibiotic Production

III. Molecular Genetics of Antibiotic Production

IV. Overview, Implications and Prospects


Chapter 8 Catabolism of Aromatic Hydrocarbons by Pseudomonas

I. Introduction

II. Biochemical Strategies for Oxidative Catabolism of Aromatics

III. Organization and Regulation of Genes for Catabolism of Aromatic Hydrocarbons

IV. Utility of Determinants of Catabolic Pathways

V. Laboratory Evolution of Aromatic Catabolic Pathways

VI. Concluding Remarks



Chapter 9 Mercury Resistance in Bacteria

I. Introduction

II. Bacterial Transformations of Mercury

III. Mercury Resistance Genes

IV. The Gram-Negative Structural Genes and Their Products

V. A Model for Mercury Resistance in Bacteria

VI. Regulation of Expression of the Mercury Resistance Genes

VII. Overview and Prospects



Section III Morphological Differentiation—Flagella Spores and Multicellular Development

Chapter 10 Differentiation in Caulobacter: Flagellum Development, Mobility and Chemotaxis

I. Introduction

II. Developmental Programs and Cell Differentiation

III. Regulation of Flagellum Biosynthesis

IV. Control of Chemotaxis and Positioning of Differentiated Structures

V. Prospects — The Cell Cycle as a Regulator of Temporal and Spatial Patterning



Chapter 11 Pathways of Developmentally Regulated Gene Expression in Bacillus subtilis

I. Introduction

II. Sporulation and Germination

III. Genes Involved in Sporulation and Germination

IV. Developmental Genes are Switched on in an Ordered Temporal Sequence

V. Compartmentalization of Gene Expression

VI. Dependence Patterns of Developmental Gene Expression: Four Examples

VII. Pathways of Developmentally Regulated Gene Expression

VIII. Overview, Implications and Prospects



Chapter 12 Multicellular Development in Myxobacteria

I. Introduction

II. Fruiting Body Development Follows a Program

III. Operon Fusions Expose a Program of Differential Gene Expression

IV. Cell Interactions Coordinate the Program of Fruiting Body Development

V. Mutants of Groups A, B, C and D Differ Genetically

VI. Expression of ß-Galactosidase from lac Fusion Strains Depends on the Products of the asg, bsg, csg and dsg Genes

VII. A-Factor and C-Factor Activities can be Found in Cell Extracts

VIII. The asg, bsg, csg and dsg Loci Can be Isolated

IX. Overview and Prospects


Section IV Bacterial Adaptations to Animal Pathogenicity

Chapter 13 The Molecular Basis of Antigenic Variation in Pathogenic Neisseria

I. Introduction

II. Diversity and Virulence

III. Genetic Mechanisms for Pilus Variation

IV. Genetic Mechanisms for P.II Variation

V. Conclusions



Chapter 14 Adhesins of Pathogenic Escherichia coli

I. Introduction

II. Bacterial Adherence to Animal Tissues

III. Adhesin Genetics

IV. Evolutionary Perspectives


Chapter 15 Genetic Studies of Enterotoxin and Other Potential Virulence Factors of Vibrio cholerae

I. Introduction

II. Cholera Toxin Genes

III. Adherence and Colonization

IV. Other Potential Virulence Factors

V. Regulation of Virulence Gene Expression

VI. Perspectives


Chapter 16 Iron Scavenging in the Pathogenesis of Escherichia coli

I. Introduction

II. Enterobacterial Iron Uptake Systems

III. Molecular Genetics

IV. Biochemical Genetics

V. Regulation

VI. Epilogue


Section V Bacteria that Interact with Plants as Parasites or Symbionts

Chapter 17 Pathogenicity of Xanthomonas and Related Bacteria towards Plants

I. Introduction

II. Strategies and Techniques for Studying the Genetics of Pathogenicity

III. Function of Some Pathogenicity Genes

IV. Concluding Remarks


Chapter 18 Tumorigenicity of Agrobacterium on Plants

I. Introduction

II. Ti and Ri Plasmids


IV. Genes and Sequences Necessary for T-DNA Transfer

V. Different Steps in the Process of Tumor Induction

VI. Prospects for Application


Chapter 19 The Symbiosis between Rhizobium and Legumes

I. Introduction

II. Methods for Identifying Bacterial Genes Involved in Nodulation

III. Polysaccharide Synthesis is Important for Nodulation

IV. Analysis of nod Gene Function

V. Regulation of nod Gene Transcription

VI. Conclusions


Section VI Bacterial Population Genetics

Chapter 20 The Population Genetics of Bacteria

I. Introduction

II. Genetic Variation and its Interpretation

III. Species Boundaries and Evolutionary Relationships

IV. The Importance of Accessory Elements

V. Experimental Evolution

VI. The Planned Release of Novel Organisms



No. of pages:
© Academic Press 1988
1st December 1988
Academic Press
eBook ISBN:

About the Editors

David A. Hopwood

Keith F. Chater

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