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Genetics, Neurology, Behavior, and Diet in Dementia - 1st Edition - ISBN: 9780128158685

Genetics, Neurology, Behavior, and Diet in Dementia

1st Edition

The Neuroscience of Dementia, Volume 2

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Editors: Colin R. Martin Victor Preedy
Hardcover ISBN: 9780128158685
Imprint: Academic Press
Published Date: 28th August 2020
Page Count: 952
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Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. It is suitable for graduate/postgraduate students, lecturers, and professors

Table of Contents


Carolyn Roberts


I. Genetics, Molecular and Cellular Biology

1. The genetics of Alzheimer’s disease: a focus on the neuron navigator 2 gene

Kesheng Wang and Chun Xu

2. Interlinking polymorphisms, estrogens and Alzheimer’s disease

Y. Q. Song

3. Linking EEGs, Alzheimer’s disease and the Phosphatidylinositol binding clathrin assembly protein (PICALM) gene

Natalya Ponomareva

4. CD36 gene polymorphism and Alzheimer’s disease

O. Sery

5. Genetic contributions to sporadic frontotemporal dementia

Jennifer S. Yokoyama and Jessie S. Carr

6. Dementia and CYP2D6 polymorphisms

P. Caramelli

7. A1 purinergic receptor gene expression in dementia

Guadalupe Maria Garcia-Alcocer

8. Molecular aspects of metallothionein-1 in dememtias

Juan Hidalgo

9. MicroRNAs in Alzheimer's disease

Urszula Wojda

10. Oxidative stress and neurons in dementia

Elena Miranda

11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer's disease neurodegeneration

Nibaldo C. Inestrosa and Juan Zolezzi

12. Wnt Signalling and dementia

A.Angeles Martin-Requero Sr.

13. Linking PKC, PKClambda/I and Alzheimer’s disease

Robert V. Farese

14. Linking histone deacetylases, phosphodiesterase 5 and novel treatments Alzheimer’s disease

Ana Garcia-Osta

15. Linking Nrf2 and Alzheimers disease

Joshua Park

16. Role of alpha- and beta-secretase in Alzheimer’s disease

Kristina Endres

17. Methylation analysis of DNA in Alzheimer’s disease

Fabio Coppedè

18. The signalosome malfunctions in age-associated neuropathologies

Raquel Marin

19. ILEI/FAM3C in Alzheimer’s disease

Masaki Nishimura

20. Amylin and Alzheimer’s disease

Jack H. Jhamandas

21. Mammalian target of rapamycin (mTOR) complexes: Regulation and Alzheimer's disease

Henry Querfurth and Han Kyu Lee

22. Mammalian target of rapamycin (mTOR) complexes: Protein synthesis and autophagy, Parkinsons Disease, Amyotrophic Lateral Sclerosis and frontotemporal dementia

Henry Querfurth and Han Kyu Lee

23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation

D. Walker

II. Neurological, Physiological and Imaging

24. Hippocampal atrophy and dementia

Hiroshi Yao

25. Inflammation and insulin resistance in AD: partners in crime

D. Frenkel

26. Neuronal susceptibility to hypoxia in Alzheimer disease

Laura Calza

27. Neuropeptides and Neurolipids: what they are and how they relate to Alzheimers disease

Rafael Rodriguez

28. Brain receptors in Alzheimer’s disease

Rafael Rodriguez

29. Abeta42-alpha7-like nicotinic acetylcholine receptors and Alzheimer’s disease

Hoau-Yan Wang

30. Synaptosomal bioenergetics in Alzheimer’s disease

Laura Morelli

31. Limitations of amyloid-PET imaging

David Weidman

32. Linking Gradient Echo Plural Contrast Imaging (GEPCI) Metrics of Tissue Microstructure with Alzheimer

Dmitry A. Yablonskiy

33. Hypertensive disorders in pregnancy and later dementia

Ellika Andolf

34. Sleep architecture and the development of clinical dementia

Matthew Paul Pase

III. Behaviour and Psychopathology

35. An overview of behavioural and psychiatric symptoms of dementia

Dorothy M. Grillo

36. Delirium superimposed on dementia: from diagnosis to treatment

Alessandro Morandi

37. Self-Consciousness Deficits in dementia

E. Arroyo-Anllo

38. Attention impairements, novel images and Alzheimer’s disease

Krista Lanctot

39. Frontal Lobe Syndrome and Dementias

Petronilla Battista

40. The stigma of dementia

Albert Aboseif and Benjamin K.P. Woo

41. Delusions in dementias

Francesco Panza

42. Linking motor speech function and dementia

Adam P. Vogel and Matthew Poole

43. Spatial Navigation and Alzheimer’s disease

Benjamin Clark

44. Violence and dementia

G. Cipriani and Sabrina Danti

45. Caregiver depression in dementia

Sheung Tak Cheng

IV. Diet, Nutrition and Environment

46. Nutritional status in dementia

Kyung Ja Chang

47. Selenium and Alzheimer’s disease

Bárbara R. Cardoso

48. Linking adiponectin and obesity in dementia

M. Bednarska-Makaruk

49. The gut microbiome in Alzheimer's Disease

Kristina Endres

50. (-)-epigallocatechin-3-gallate (EGCG) and Alzheimer disease

Rafael de la Torre and Laura Xicota

51. Cadmium and Alzheimer’s disease

Sung Kyun Park

V. Models And Modelling In Dementia

52. Alzheimer's model 5xFAD mice as a model and applications to dementia

Yasuhisa Ano

53. Use of 192 IgG-saporin as a model of dementia and its application

Jin Woo Chang and Yong-sook Park

54. Abeta1-42 oligomer animal model of dementia

Josiane Budni


Rajkumar Rajendram


No. of pages:
© Academic Press 2020
28th August 2020
Academic Press
Hardcover ISBN:

About the Editors

Colin R. Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Perinatal Mental Health, Institute of Clinical and Applied Health Research (ICAHR), University of Hull, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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