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Genetics, Neurology, Behavior, and Diet in Dementia - 1st Edition - ISBN: 9780128158685, 9780128158692

Genetics, Neurology, Behavior, and Diet in Dementia

1st Edition

The Neuroscience of Dementia, Volume 2

Editors: Colin Martin Victor Preedy
Hardcover ISBN: 9780128158685
eBook ISBN: 9780128158692
Imprint: Academic Press
Published Date: 11th August 2020
Page Count: 952
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Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. It is suitable for graduate/postgraduate students, lecturers, and professors

Table of Contents

Part I: Genetics, molecular and cellular biology

1. The neuron navigator 2 gene and Alzheimer’s disease
Chun Xu, Brenda Bin Su, Stephanie Lozano and Kesheng Wang

2. Interlinking polymorphisms, estrogens, and Alzheimer disease
Lu Hua Chen, Leung Wing Chu and You-Qiang Song

3. Linking EEGs, Alzheimer disease, and the phosphatidylinositol-binding clathrin assembly protein (PICALM) gene
Natalya Ponomareva, Tatiana Andreeva, Vitaly Fokin, Sergey Illarioshkin and Evgeny Rogaev

4. CD36 gene polymorphisms and Alzheimer’s disease
Omar Šerý, Nandu Goswami and Vladimir J. Balcar

5. Genetic contributions to sporadic frontotemporal dementia
Jessie S. Carr, Daniel W. Sirkis and Jennifer S. Yokoyama

6. Clinical response to cholinesterase inhibitors in dementia: the role of CYP2D6 and APOE genetic polymorphisms
Luís Felipe José Ravic de Miranda, Karina Braga Gomes and Paulo Caramelli

7. A1 and A2 purinergic receptor expression in dementia
J. Mendiola-Precoma, L.C. Berumen, A. Rodríguez-Cruz and G. García-Alcocer

8. Molecular aspects of metallothioneins in dementias
Gemma Comes, Anna Escrig, Yasmina Manso, Olaya Fernández-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco and Juan Hidalgo

9. Implication of microRNAs in Alzheimer’s disease pathogenesis
Katarzyn Marta Zoltowska, Katarzyna Laskowska-Kaszub, Siranjeevi Nagaraj and Urszula Wojda

10. Role of cellular oxidative stress in dementia
Giovanna Galliciotti, Antonella De Jaco, Diego Sepulveda-Falla, Emanuela D’Acunto and Elena Miranda

11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer disease neurodegeneration
Juan M. Zolezzi, Paulina Villaseca and Nibaldo C. Inestrosa

12. Wnt signaling and dementia
Carolina Alquezár and Ángeles Martín-Requero

13. Linkage of atypical protein kinase C to Alzheimer disease
Robert V. Farese and Mini P. Sajan

14. Linking histone deacetylases and phosphodiesterase 5 in novel treatments for Alzheimer’s disease
Ana Garcia-Osta and Mar Cuadrado-Tejedor

15. Nuclear factor erythroid 2-related factor 2 in Alzheimer’s disease
Kelsey E. Murphy and Joshua J. Park

16. Implications of alpha- and beta-secretase expression and function in Alzheimer’s disease
Sven Reinhardt and Kristina Endres

17. Methylation analysis of DNA in Alzheimer’s disease
Fabio Coppedè

18. The signalosome malfunctions in age-associated neuropathologies
Ricardo Puertas-Avendaño, David Quinto-Alemany, Miriam González-Gómez and Raquel Marin

19. FAM3C in Alzheimer’s disease: a risk-related molecule and potential therapeutic target
Masaki Nishimura, Naoki Watanabe, Emi Hibino, Masaki Nakano, Yachiyo Mitsuishi, Lei Liu and Takuma Sugi

20. Amylin and amylin receptors in Alzheimer’s disease
Wen Fu and Jack H. Jhamandas

21. Mammalian target of rapamycin complexes: regulation and Alzheimer’s disease
Henry Querfurth and Han-Kyu Lee

22. Mammalian target of rapamycin complexes: protein synthesis and autophagy, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
Henry Querfurth and Han-Kyu Lee

23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation
Douglas Gordon Walker

Part II: Neurological, physiological and imaging

24. Hippocampal atrophy associated with dementia risk factors and dementia
Hiroshi Yao, Yuko Araki, Fumio Yamashita, Makoto Sasaki and Manabu Hashimoto

25. Inflammation and insulin resistance in Alzheimer’s disease: partners in crime
Yuval Nash and Dan Frenke

26. Brain susceptibility to hypoxia/hypoxemia and metabolic dysfunction in Alzheimer’s disease: insights from animal and in vitro models
Vito Antonio Baldassarro, Andrea Bighinati, Michele Sannia, Luciana Giardino and Laura Calzà

27. Neuropeptides and neurolipids: what they are and how they relate to Alzheimer’s disease
Iván Manuel, Laura Lombardero, Alberto Llorente-Ovejero and Rafael Rodríguez-Puertas

28. Neurotransmitter receptors in Alzheimer’s disease: from glutamatergic to cholinergic receptors
Laura Lombardero, Alberto Llorente-Ovejero, Iván Manuel and Rafael Rodríguez-Puertas

29. Aβ42-α7-like nicotinic acetylcholine receptors and Alzheimer’s disease
Hoau-Yan Wang and Amber Khan

30. Synaptosomal bioenergetic defects in Alzheimer’s disease
Pamela V. Martino Adami and Laura Morelli

31. Limitations of amyloid imaging in Alzheimer’s disease
David Weidman

32. Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease
Dmitriy A. Yablonskiy, Tammie L. Benzinger and John C. Morris

33. Hypertensive disorders during pregnancy and later dementia: is there a connection?
Ellika Andolf

34. Unraveling the contributions of sleep dysfunction to Alzheimer’s disease
Elie Gottlieb, Natalie A. Grima, Mark Howard, Amy Brodtmann and Matthew P. Pase

Part III: Behaviour and psychopathology

35. Overview of behaviors in dementia
Dorothy M. Grillo and Rachel Anderson

36. Delirium superimposed on dementia: a clinical challenge from diagnosis to treatment
Morandi Alessandro, Pozzi Christian, Grossi Eleonora and Bellelli Giuseppe

37. Self-consciousness deficits in dementia
Eva M. Arroyo-Anlló and Roger Gil

38. Attentional impairments to novel images in dementia
Celina S. Liu, Michael Rosen, Nathan Herrmann and Krista L. Lanctôt

39. Frontal lobe syndrome and dementias
Petronilla Battista, Chiara Griseta, Rosa Capozzo, Madia Lozupone, Rodolfo Sardone, Francesco Panza and Giancarlo Logroscino

40. The stigma of dementia
Albert Aboseif and Benjamin K.P. Woo

41. Delusions in dementias
Madia Lozupone, Maddalena La Montagna, Antonello Bellomo, Petronilla Battista, Davide Seripa, Antonio Daniele, Antonio Greco, Onofrio Resta, Giancarlo Logroscino and Francesco Panza

42. Linking motor speech function and dementia
Matthew L. Poole and Adam P. Vogel

43. Spatial navigation and Alzheimer’s disease
Laura E. Berkowitz, Ryan E. Harvey and Benjamin J. Clark

44. Violence and dementia
G. Cipriani, S. Danti, A. Nuti, L. Picchi and M. Di Fiorino

45. Factors contributing to protection and vulnerability in dementia caregivers
Fan Zhang, Sheung-Tak Cheng and Manuel Gonçalves-Pereira

Part IV: Diet, nutrition and environment

46. Nutritional status of dementia and management using dietary taurine supplementation
Mi Ae Bae and Kyung Ja Chang

47. Selenium and Alzheimer’s disease
Adriana Gisele Hertzog da Silva Leme and Barbara R. Cardoso

48. Linking adiponectin and obesity in dementia
Ma1gorzata Bednarska-Makaruk

49. The impact of the gut microbiome in Alzheimer’s disease: cause or consequence?
Malena dos Santos Guilherme and Kristina Endres

50. (-)-Epigallocatechin-3-gallate and Alzheimer’s disease
Laura Xicota and Rafael de la Torre

51. Lead, cadmium and Alzheimer’s disease
Kelly M. Bakulski, Howard Hu and Sung Kyun Park

Part V: Models and modelling in dementia

52. Alzheimer model 5xfad mice and applications to dementia: transgenic mouse models, a focus on neuroinflammation, microglia, and food-derived components
Tatsuhiro Ayabe and Yasuhisa Ano

53. Use of 192 IgG-saporin as a model of dementia and its application
J.W. Chang and Y.S. Park

54. Amyloid beta 1e42-induced animal model of dementia: a review
Josiane Budni and Jade de Oliveira

55. Resources for the neuroscience of dementia
Rajkumar Rajendram and Victor R. Preedy


No. of pages:
© Academic Press 2020
11th August 2020
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Ratings and Reviews