Genetics, Neurology, Behavior, and Diet in Dementia
1st Edition
The Neuroscience of Dementia, Volume 2
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Description
The Neuroscience of Dementia: Genetics, Neurology, Behavior, and Diet in Dementia brings together different fields of dementia into a single coherent book. It covers a wide range of subjects including the different types of dementia (Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia), physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and many other focused areas. This foundational, comprehensive book brings together the current status of understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.
Key Features
- The most comprehensive coverage of the broad range of topics related to Dementia
- Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
- Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
- Uniquely sections on specific subareas, intellectual components and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
- Preclinical and clinical studies will help researchers map out key areas for research and further clinical recommendations
- A "one-stop" source for everything you need to know about Dementia
Readership
Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. It is suitable for graduate/postgraduate students, lecturers, and professors
Table of Contents
Foreword
Carolyn Roberts
Preface
I. Genetics, Molecular and Cellular Biology
1. The genetics of Alzheimer’s disease: a focus on the neuron navigator 2 gene
Kesheng Wang and Chun Xu
2. Interlinking polymorphisms, estrogens and Alzheimer’s disease
Y. Q. Song
3. Linking EEGs, Alzheimer’s disease and the Phosphatidylinositol binding clathrin assembly protein (PICALM) gene
Natalya Ponomareva
4. CD36 gene polymorphism and Alzheimer’s disease
O. Sery
5. Genetic contributions to sporadic frontotemporal dementia
Jennifer S. Yokoyama and Jessie S. Carr
6. Dementia and CYP2D6 polymorphisms
P. Caramelli
7. A1 purinergic receptor gene expression in dementia
Guadalupe Maria Garcia-Alcocer
8. Molecular aspects of metallothionein-1 in dememtias
Juan Hidalgo
9. MicroRNAs in Alzheimer's disease
Urszula Wojda
10. Oxidative stress and neurons in dementia
Elena Miranda
11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer's disease neurodegeneration
Nibaldo C. Inestrosa and Juan Zolezzi
12. Wnt Signalling and dementia
A.Angeles Martin-Requero Sr.
13. Linking PKC, PKClambda/I and Alzheimer’s disease
Robert V. Farese
14. Linking histone deacetylases, phosphodiesterase 5 and novel treatments Alzheimer’s disease
Ana Garcia-Osta
15. Linking Nrf2 and Alzheimers disease
Joshua Park
16. Role of alpha- and beta-secretase in Alzheimer’s disease
Kristina Endres
17. Methylation analysis of DNA in Alzheimer’s disease
Fabio Coppedè
18. The signalosome malfunctions in age-associated neuropathologies
Raquel Marin
19. ILEI/FAM3C in Alzheimer’s disease
Masaki Nishimura
20. Amylin and Alzheimer’s disease
Jack H. Jhamandas
21. Mammalian target of rapamycin (mTOR) complexes: Regulation and Alzheimer's disease
Henry Querfurth and Han Kyu Lee
22. Mammalian target of rapamycin (mTOR) complexes: Protein synthesis and autophagy, Parkinsons Disease, Amyotrophic Lateral Sclerosis and frontotemporal dementia
Henry Querfurth and Han Kyu Lee
23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation
D. Walker
II. Neurological, Physiological and Imaging
24. Hippocampal atrophy and dementia
Hiroshi Yao
25. Inflammation and insulin resistance in AD: partners in crime
D. Frenkel
26. Neuronal susceptibility to hypoxia in Alzheimer disease
Laura Calza
27. Neuropeptides and Neurolipids: what they are and how they relate to Alzheimers disease
Rafael Rodriguez
28. Brain receptors in Alzheimer’s disease
Rafael Rodriguez
29. Abeta42-alpha7-like nicotinic acetylcholine receptors and Alzheimer’s disease
Hoau-Yan Wang
30. Synaptosomal bioenergetics in Alzheimer’s disease
Laura Morelli
31. Limitations of amyloid-PET imaging
David Weidman
32. Linking Gradient Echo Plural Contrast Imaging (GEPCI) Metrics of Tissue Microstructure with Alzheimer
Dmitry A. Yablonskiy
33. Hypertensive disorders in pregnancy and later dementia
Ellika Andolf
34. Sleep architecture and the development of clinical dementia
Matthew Paul Pase
III. Behaviour and Psychopathology
35. An overview of behavioural and psychiatric symptoms of dementia
Dorothy M. Grillo
36. Delirium superimposed on dementia: from diagnosis to treatment
Alessandro Morandi
37. Self-Consciousness Deficits in dementia
E. Arroyo-Anllo
38. Attention impairements, novel images and Alzheimer’s disease
Krista Lanctot
39. Frontal Lobe Syndrome and Dementias
Petronilla Battista
40. The stigma of dementia
Albert Aboseif and Benjamin K.P. Woo
41. Delusions in dementias
Francesco Panza
42. Linking motor speech function and dementia
Adam P. Vogel and Matthew Poole
43. Spatial Navigation and Alzheimer’s disease
Benjamin Clark
44. Violence and dementia
G. Cipriani and Sabrina Danti
45. Caregiver depression in dementia
Sheung Tak Cheng
IV. Diet, Nutrition and Environment
46. Nutritional status in dementia
Kyung Ja Chang
47. Selenium and Alzheimer’s disease
Bárbara R. Cardoso
48. Linking adiponectin and obesity in dementia
M. Bednarska-Makaruk
49. The gut microbiome in Alzheimer's Disease
Kristina Endres
50. (-)-epigallocatechin-3-gallate (EGCG) and Alzheimer disease
Rafael de la Torre and Laura Xicota
51. Cadmium and Alzheimer’s disease
Sung Kyun Park
V. Models And Modelling In Dementia
52. Alzheimer's model 5xFAD mice as a model and applications to dementia
Yasuhisa Ano
53. Use of 192 IgG-saporin as a model of dementia and its application
Jin Woo Chang and Yong-sook Park
54. Abeta1-42 oligomer animal model of dementia
Josiane Budni
Resources
Rajkumar Rajendram
Details
- No. of pages:
- 745
- Language:
- English
- Copyright:
- © Academic Press 2020
- Published:
- 1st August 2020
- Imprint:
- Academic Press
- Hardcover ISBN:
- 9780128158685
About the Editor
Colin Martin
Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).
Affiliations and Expertise
Professor of Perinatal Mental Health, Institute of Clinical and Applied Health Research (ICAHR), University of Hull, UK
Victor Preedy
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.
Affiliations and Expertise
Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK
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