Genetics, Neurology, Behavior, and Diet in Dementia

Genetics, Neurology, Behavior, and Diet in Dementia

The Neuroscience of Dementia, Volume 2

1st Edition - August 11, 2020

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  • Editors: Colin Martin, Victor Preedy
  • Hardcover ISBN: 9780128158685
  • eBook ISBN: 9780128158692

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Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers comprehensive coverage of a broad range of topics related to dementia
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about dementia


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. It is suitable for graduate/postgraduate students, lecturers, and professors

Table of Contents

  • Part I: Genetics, molecular and cellular biology

    1. The neuron navigator 2 gene and Alzheimer’s disease
    Chun Xu, Brenda Bin Su, Stephanie Lozano and Kesheng Wang

    2. Interlinking polymorphisms, estrogens, and Alzheimer disease
    Lu Hua Chen, Leung Wing Chu and You-Qiang Song

    3. Linking EEGs, Alzheimer disease, and the phosphatidylinositol-binding clathrin assembly protein (PICALM) gene
    Natalya Ponomareva, Tatiana Andreeva, Vitaly Fokin, Sergey Illarioshkin and Evgeny Rogaev

    4. CD36 gene polymorphisms and Alzheimer’s disease
    Omar Šerý, Nandu Goswami and Vladimir J. Balcar

    5. Genetic contributions to sporadic frontotemporal dementia
    Jessie S. Carr, Daniel W. Sirkis and Jennifer S. Yokoyama

    6. Clinical response to cholinesterase inhibitors in dementia: the role of CYP2D6 and APOE genetic polymorphisms
    Luís Felipe José Ravic de Miranda, Karina Braga Gomes and Paulo Caramelli

    7. A1 and A2 purinergic receptor expression in dementia
    J. Mendiola-Precoma, L.C. Berumen, A. Rodríguez-Cruz and G. García-Alcocer

    8. Molecular aspects of metallothioneins in dementias
    Gemma Comes, Anna Escrig, Yasmina Manso, Olaya Fernández-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco and Juan Hidalgo

    9. Implication of microRNAs in Alzheimer’s disease pathogenesis
    Katarzyn Marta Zoltowska, Katarzyna Laskowska-Kaszub, Siranjeevi Nagaraj and Urszula Wojda

    10. Role of cellular oxidative stress in dementia
    Giovanna Galliciotti, Antonella De Jaco, Diego Sepulveda-Falla, Emanuela D’Acunto and Elena Miranda

    11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer disease neurodegeneration
    Juan M. Zolezzi, Paulina Villaseca and Nibaldo C. Inestrosa

    12. Wnt signaling and dementia
    Carolina Alquezár and Ángeles Martín-Requero

    13. Linkage of atypical protein kinase C to Alzheimer disease
    Robert V. Farese and Mini P. Sajan

    14. Linking histone deacetylases and phosphodiesterase 5 in novel treatments for Alzheimer’s disease
    Ana Garcia-Osta and Mar Cuadrado-Tejedor

    15. Nuclear factor erythroid 2-related factor 2 in Alzheimer’s disease
    Kelsey E. Murphy and Joshua J. Park

    16. Implications of alpha- and beta-secretase expression and function in Alzheimer’s disease
    Sven Reinhardt and Kristina Endres

    17. Methylation analysis of DNA in Alzheimer’s disease
    Fabio Coppedè

    18. The signalosome malfunctions in age-associated neuropathologies
    Ricardo Puertas-Avendaño, David Quinto-Alemany, Miriam González-Gómez and Raquel Marin

    19. FAM3C in Alzheimer’s disease: a risk-related molecule and potential therapeutic target
    Masaki Nishimura, Naoki Watanabe, Emi Hibino, Masaki Nakano, Yachiyo Mitsuishi, Lei Liu and Takuma Sugi

    20. Amylin and amylin receptors in Alzheimer’s disease
    Wen Fu and Jack H. Jhamandas

    21. Mammalian target of rapamycin complexes: regulation and Alzheimer’s disease
    Henry Querfurth and Han-Kyu Lee

    22. Mammalian target of rapamycin complexes: protein synthesis and autophagy, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
    Henry Querfurth and Han-Kyu Lee

    23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation
    Douglas Gordon Walker

    Part II: Neurological, physiological and imaging

    24. Hippocampal atrophy associated with dementia risk factors and dementia
    Hiroshi Yao, Yuko Araki, Fumio Yamashita, Makoto Sasaki and Manabu Hashimoto

    25. Inflammation and insulin resistance in Alzheimer’s disease: partners in crime
    Yuval Nash and Dan Frenke

    26. Brain susceptibility to hypoxia/hypoxemia and metabolic dysfunction in Alzheimer’s disease: insights from animal and in vitro models
    Vito Antonio Baldassarro, Andrea Bighinati, Michele Sannia, Luciana Giardino and Laura Calzà

    27. Neuropeptides and neurolipids: what they are and how they relate to Alzheimer’s disease
    Iván Manuel, Laura Lombardero, Alberto Llorente-Ovejero and Rafael Rodríguez-Puertas

    28. Neurotransmitter receptors in Alzheimer’s disease: from glutamatergic to cholinergic receptors
    Laura Lombardero, Alberto Llorente-Ovejero, Iván Manuel and Rafael Rodríguez-Puertas

    29. Aβ42-α7-like nicotinic acetylcholine receptors and Alzheimer’s disease
    Hoau-Yan Wang and Amber Khan

    30. Synaptosomal bioenergetic defects in Alzheimer’s disease
    Pamela V. Martino Adami and Laura Morelli

    31. Limitations of amyloid imaging in Alzheimer’s disease
    David Weidman

    32. Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease
    Dmitriy A. Yablonskiy, Tammie L. Benzinger and John C. Morris

    33. Hypertensive disorders during pregnancy and later dementia: is there a connection?
    Ellika Andolf

    34. Unraveling the contributions of sleep dysfunction to Alzheimer’s disease
    Elie Gottlieb, Natalie A. Grima, Mark Howard, Amy Brodtmann and Matthew P. Pase

    Part III: Behaviour and psychopathology

    35. Overview of behaviors in dementia
    Dorothy M. Grillo and Rachel Anderson

    36. Delirium superimposed on dementia: a clinical challenge from diagnosis to treatment
    Morandi Alessandro, Pozzi Christian, Grossi Eleonora and Bellelli Giuseppe

    37. Self-consciousness deficits in dementia
    Eva M. Arroyo-Anlló and Roger Gil

    38. Attentional impairments to novel images in dementia
    Celina S. Liu, Michael Rosen, Nathan Herrmann and Krista L. Lanctôt

    39. Frontal lobe syndrome and dementias
    Petronilla Battista, Chiara Griseta, Rosa Capozzo, Madia Lozupone, Rodolfo Sardone, Francesco Panza and Giancarlo Logroscino

    40. The stigma of dementia
    Albert Aboseif and Benjamin K.P. Woo

    41. Delusions in dementias
    Madia Lozupone, Maddalena La Montagna, Antonello Bellomo, Petronilla Battista, Davide Seripa, Antonio Daniele, Antonio Greco, Onofrio Resta, Giancarlo Logroscino and Francesco Panza

    42. Linking motor speech function and dementia
    Matthew L. Poole and Adam P. Vogel

    43. Spatial navigation and Alzheimer’s disease
    Laura E. Berkowitz, Ryan E. Harvey and Benjamin J. Clark

    44. Violence and dementia
    G. Cipriani, S. Danti, A. Nuti, L. Picchi and M. Di Fiorino

    45. Factors contributing to protection and vulnerability in dementia caregivers
    Fan Zhang, Sheung-Tak Cheng and Manuel Gonçalves-Pereira

    Part IV: Diet, nutrition and environment

    46. Nutritional status of dementia and management using dietary taurine supplementation
    Mi Ae Bae and Kyung Ja Chang

    47. Selenium and Alzheimer’s disease
    Adriana Gisele Hertzog da Silva Leme and Barbara R. Cardoso

    48. Linking adiponectin and obesity in dementia
    Ma1gorzata Bednarska-Makaruk

    49. The impact of the gut microbiome in Alzheimer’s disease: cause or consequence?
    Malena dos Santos Guilherme and Kristina Endres

    50. (-)-Epigallocatechin-3-gallate and Alzheimer’s disease
    Laura Xicota and Rafael de la Torre

    51. Lead, cadmium and Alzheimer’s disease
    Kelly M. Bakulski, Howard Hu and Sung Kyun Park

    Part V: Models and modelling in dementia

    52. Alzheimer model 5xfad mice and applications to dementia: transgenic mouse models, a focus on neuroinflammation, microglia, and food-derived components
    Tatsuhiro Ayabe and Yasuhisa Ano

    53. Use of 192 IgG-saporin as a model of dementia and its application
    J.W. Chang and Y.S. Park

    54. Amyloid beta 1e42-induced animal model of dementia: a review
    Josiane Budni and Jade de Oliveira

    55. Resources for the neuroscience of dementia
    Rajkumar Rajendram and Victor R. Preedy


Product details

  • No. of pages: 952
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 11, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128158685
  • eBook ISBN: 9780128158692

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King’s College London and Professor of Clinical Biochemistry (Hon) at King’s College Hospital. He was the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Emeritus Professor, King’s College London; Professor, King’s College Hospital, London, UK

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