Genetics and Evolution of Infectious Diseases - 1st Edition - ISBN: 9780123848901, 9780123848918

Genetics and Evolution of Infectious Diseases

1st Edition

Editors: Michel Tibayrenc
eBook ISBN: 9780123848918
Hardcover ISBN: 9780123848901
Imprint: Elsevier
Published Date: 17th December 2010
Page Count: 772
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This multidisciplinary book is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches.

Key Features

  • Takes an integrated approach to infectious diseases
  • Includes contributions from leading authorities
  • Provides the latest developments in the field


Researchers in infectious disease, epidemiology, genetics and evolutionary biology and health professionals

Table of Contents

Introduction: the need for a holistic approach to infectious diseases - Michel Tibayrenc

(1) Molecular epidemiology and species definition of pathogens - Michel Tibayrenc

(2) Virus species- Marc Van Regenmortel

(3) Viral evolution- Hiroshi Haeno and Yoh

(4) Species concept in bacteria - Frederick M. Cohan

(5) Population structure of pathogenic bacteria - James Musser & Robert Selander

(6) Evolution and pathogenesis of fungal organisms – Tatiana Giraud et al

(7) Clonal evolution - Thierry de Meeus & Franck Prugnolle

(8) Co-evolution between host and pathogen - Andrew Morgan

(9) Elucidating human migration by means of their pathogens - Thierry Wirth

(10) Phylogenetic analysis of pathogens - David A. Morrison

(11) Evolutionary effects of infectious diseases on humans - Henry Harpending & Gregory Cochran

(12) General human population genetics, major genomic projects and their

relevance for biomedical research - Michel Tibayrenc

(13) Pathogen and vector sequencing projects - Brendan Loftus

(14) Proteomics and Host–Pathogen Interactions: a bright future? David Biron et al

(15) Evolution of antibiotic resistance - Mark C. Enright

(16) Mechanisms of antiviral resistance - Anthony Vere Hodge & Hugh Field,

(17) Evolution of resistance to insecticides in disease vectors - Pierrick Labbé et al

(18) Genetics of major insect vectors – Patricia Dorn et al

(19) Modern morphometrics of medically important insects - Jean-Pierre Dujardin

(20) Multilocus sequence typing of pathogens - Marcos Perez-Losada et al

(21) Analysis of pathogen evolution using microarrays – Wei Zhang

(22) The bioinformatics revolution and infectious diseases - Mark van der Giezen

(23) Genomics of infectious diseases and private industry - Guy Vernet

(24) Pharmacogenetics: The à la carte medicine of tomorrow? - Iris Grossman

(25) Experimental recombination in trypanosomes: its relevance for formal

genetics and epidemiology - Wendy Gibson et al

(26) Population genetics of Plasmodium falciparum and the challenge of drug

Resistance - Colin Sutherland

(27) Molecular evolution of Trypanosoma cruzi: a new paradigmal model of

basic science? – Jenny Tellaria et al

(28) Identification of Mycobacterium tuberculosis populations using

microarrays: does it permit routine molecular epidemiology? Sébastien Gagneux & Marcel Behr

(29) The evolution and dynamics of methicillin-resistant Staphylococcus

aureus: can it be controlled by public health measures? Gerrit Kuhn & Dominique Blanc

(30) The origins of human immunodeficiency virus and implications for global

Epidemics - Eric Delaporte

(31) Evolution of SARS coronavirus and the relevance of modern molecular

Epidemiology - Zhengli Shi et al

(32) Ecology and evolution of avian influenza: the risk of a major pandemics-

Ron. A.M. Fouchier


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About the Editor

Michel Tibayrenc

Michel Tibayrenc

Michel Tibayrenc, MD, PhD, has worked on the evolution of infectious diseases for more than 35 years. He is a director of research emeritus at the French Institut de Recherche pour le Développement (IRD), the founder and editor-in-chief of Infection, Genetics and Evolution (Elsevier), with a 2014 impact factor of 3.015, and the founder and principal organizer of the international congresses MEEGID (molecular epidemiology and evolutionary genetics of infectious diseases). He is the author of more than 200 international papers. He has worked for one year in Algeria (as a general practitioner), one year in French Guiana, seven years in Bolivia, five years in the United States, and three years in Thailand. He has been the head of the unit of research “genetics and evolution of infectious diseases” at the IRD research center in Montpellier, France, for 20 years. With his collaborator Jenny Telleria, he is the founder and scientific adviser of the Bolivian Society of Human Genetics (2012). He has won the prize of the Belgian Society of tropical medicine (1985), the medal of the Instituto Oswaldo Cruz, Rio de Janeiro (2000), for his work on Chagas disease, and he is a fellow of the American Association for the Advancement of Science (1993).

Affiliations and Expertise

Genetics and Evolution of Infectious Diseases Laboratory, IRD Center, Montpellier, France

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