Genetic Recombination in Cancer

Genetic Recombination in Cancer

1st Edition - July 24, 2003

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  • Author: Gajanan Sherbet
  • eBook ISBN: 9780080521909

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Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information.

Key Features

* Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells
* Examines the role of genetic recombination in cancer including cancer invasion and metastasis
* Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers


Researchers, post-graduate and graduate students in molecular medicine, genetics, cancer biology and molecular biology.

Table of Contents

  • Genetic Integrity, DNA Repair and Recombination
    Replication Error (RER) and Genetic Instability
    DNA Repeats, Genetic Recombination and the Pathogenesis of Genetic Disorders
    Chromosomal Recombination in Cancer
    Chromosomal Translocation and its Phenotypic Outcome
    DNA Methylation and Genetic Instability
    Telomeric DNA and Genetic Instability

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Academic Press 2003
  • Published: July 24, 2003
  • Imprint: Academic Press
  • eBook ISBN: 9780080521909

About the Author

Gajanan Sherbet

Dr. Gajanan V. Sherbet is Doctor of Science of London University and Fellow of the Royal College of Pathologists and the Royal Society of Chemistry. He is member of the editorial boards of many scientific and medical journals, and formerly editor of Experimental Cell Biology and Pathobiology. Dr. Sherbet’s major scientific interest is in cancer metastasis. He has focused on the role of growth factors and their signaling, and the calcium binding protein S100A4 in cell proliferation, cancer invasion and metastasis; also he is currently studying the potential of artificial neural networks for predicting breast cancer progression and prognosis. Dr. Sherbet has numerous scientific papers in international journals and has written and edited several books on cancer, such as Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (2011) and Therapeutic Strategies in Cancer Biology and Pathology (2013), and e-books on the role of growth factors and their receptors in cancer therapy and therapeutic strategies in cancer biology and molecular pathology.

Affiliations and Expertise

Professor, Institute for Molecular Medicine, Huntington Beach CA, USA and Professor (visiting), School of Electrical and Electronic Engineering, University of Newcastle upon Tyne, UK

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