Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders - 1st Edition - ISBN: 9780444641946

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241

1st Edition

Serial Volume Editors: Anantha Shekhar
Hardcover ISBN: 9780444641946
Imprint: Academic Press
Page Count: 358
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

1. Introduction
Anantha Shekhar
2. Overview of genetic models of ASDs
Anantha Shekhar
3. Phenotypic modeling of ASD symptoms
Kathryn K. Chadman
4. Molecular mechanisms of NF1 model of ASD symptoms
Andre Molosh
5. Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD
Matthew Anderson
6. Circuit dysfunctions in ASD models
Molly Maureen Huntsman
7. ERK signaling in genetic models of ASD
Gary Landreth
8. Translating ASD models from bench to bedside
Anantha Shekhar
9. Studying child development in genetic models of ASD
Jonathan Green
10. Clinical trial methodologies for genetic forms of autism
Karin Walsh


Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders provides the most recent information about animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, the volume also provides detailed information about the translational approaches to utilizing animal model systems to gain insights into human autism and developing therapeutics.

Key Features

  • Timely subject, authoritative contributors, up to date assessment of the field, and comprehensive summaries of current knowledge, gaps and future directions


Basic researchers, preclinical neuroscientists and clinical/translational researchers developing novel diagnostics and therapeutics for autism and other neurodevelopmental disorders. This would also be great primer for graduate students and post-docs working in this field


No. of pages:
© Academic Press 2018
Academic Press
Hardcover ISBN:

Ratings and Reviews

About the Serial Volume Editors

Anantha Shekhar Serial Volume Editor

Anantha Shekhar, MD, PhD, is a distinguished professor of psychiatry, neurobiology and pharmacology at Indiana University and holds the August M. Watanabe Chair of Medical Research, Professor of Psychiatry. He has been continuously funded by the National Institutes of Health for his basic, clinical and translational research since 1989. Dr. Shekhar leads a successful basic and clinical research programs in the areas of stress, anxiety and neuropsychiatric disorders. A number of grants from the National Institutes of Health, private foundations, and commercial collaborations currently support his research. He has authored over 200 peer reviewed publications. He has received several university and national awards and has been a member and chair of several NIH study sections. He has also served as a member of the Board of Scientific Advisors for the National Institute of Mental Health. He has served as the president of the Society of Clinical and Translational Sciences and the president of the Association for Clinical and Translational Sciences. He currently serves as a member of the Advisory Council for National Center for Advancing Translation Sciences (NCATS) of the NIH and a member of the Board of Governors for the Cures Acceleration Network (CAN) at the NIH.

Affiliations and Expertise

Director, Indiana Clinical and Translational Sciences Institute, Distingushed Professor and Executive Associate Dean for Research Affairs, Indiana University School of Medicine