Genetic Dissection of Complex Traits, Volume 60

2nd Edition

Editors: D.C. Rao C. Charles Gu
Hardcover ISBN: 9780123738837
eBook ISBN: 9780080569116
Imprint: Academic Press
Published Date: 8th March 2008
Page Count: 300
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Table of Contents

I OVERVIEW AND FUNDAMENTALS 1 An Overview of Genetic Dissection of Complex Traits D. C. Rao 2 Familial Resemblance and Heritability Treva K. Rice 3 Linkage and Association: Basic Concepts Ingrid B. Borecki and Micheal A. Province 4 Definition of Phenotype Mary K. Wojczynski and Hemant K. Tiwari 5 Genotyping Platforms for Mass Throughput Genotyping with SNPs, including Human Genome-Wide Scans Karen Maresso and Ulrich Broeckel 6 Genotyping Errors and their Impact on Genetic Analysis Michael B. Miller, Karen Schwander, and D.C. Rao II LINKAGE AND ASSOCIATION ANALYSIS 7 Model-Based Methods for Linkage Analysis John P. Rice, Nancy L. Saccone and Jonathan Corbett 8 Contemporary Model-Free Methods for Linkage Analysis Laura Almasy and John Blangero 9 DNA Sequence-Based Phenotypic Association Analysis Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo 10 Family-Based Methods for Linkage and Association Analysis Nan M. Laird and Christoph Lange 11 Searching for Additional Disease Loci in a Genomic Region Glenys Thomson and Lisa F. Barcellos 12 Methods for Handling Multiple Testing Treva Rice, Nicholas J. Schork and D.C. Rao III SPECIAL TOPICS 13 Meta-analysis Methods Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, and John P.A. Ioannidis 14 Haplotype Association Analysis Nia


The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Key Features

  • Five sections on the latest advances in complex traits
  • Methods for testing with ethical, legal, and social implications
  • Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more


Geneticists, molecular biologists, neurobiologists


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© Academic Press 2008
Academic Press
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About the Editors

D.C. Rao Editor

Affiliations and Expertise

Washington University School of Medicine, St. Louis, MO, USA

C. Charles Gu Editor