The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Key Features

* Five sections on the latest advances in complex traits * Methods for testing with ethical, legal, and social implications * Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more


Geneticists, molecular biologists, neurobiologists

Table of Contents

I OVERVIEW AND FUNDAMENTALS 1 An Overview of Genetic Dissection of Complex Traits D. C. Rao 2 Familial Resemblance and Heritability Treva K. Rice 3 Linkage and Association: Basic Concepts Ingrid B. Borecki and Micheal A. Province 4 Definition of Phenotype Mary K. Wojczynski and Hemant K. Tiwari 5 Genotyping Platforms for Mass Throughput Genotyping with SNPs, including Human Genome-Wide Scans Karen Maresso and Ulrich Broeckel 6 Genotyping Errors and their Impact on Genetic Analysis Michael B. Miller, Karen Schwander, and D.C. Rao II LINKAGE AND ASSOCIATION ANALYSIS 7 Model-Based Methods for Linkage Analysis John P. Rice, Nancy L. Saccone and Jonathan Corbett 8 Contemporary Model-Free Methods for Linkage Analysis Laura Almasy and John Blangero 9 DNA Sequence-Based Phenotypic Association Analysis Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo 10 Family-Based Methods for Linkage and Association Analysis Nan M. Laird and Christoph Lange 11 Searching for Additional Disease Loci in a Genomic Region Glenys Thomson and Lisa F. Barcellos 12 Methods for Handling Multiple Testing Treva Rice, Nicholas J. Schork and D.C. Rao III SPECIAL TOPICS 13 Meta-analysis Methods Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, and John P.A. Ioannidis 14 Haplotype Association Analysis Nia


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© 2008
Academic Press
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