Membrane Fluidity in Biology, Volume 2: General Principles provides an introduction to the fundamental concepts of membrane fluidity. Key topics discussed include lateral phase separations and phase transitions; hydrophobic and electrostatic effects of membrane lipid-protein interactions; isothermal phase transitions and the effects of ionic factors; and the influence of such components as cholesterol, phospholipids, fatty acids, and cellular water on the parameters of membrane fluidity. Each of these topics is elaborated in detail to provide a unique insight into the factors influencing the thermal molecular motions of membrane components, and hence cellular membrane function. Because such activities as membrane transport, enzyme kinetics, and receptor function are modulated by the physical state of the membrane lipids and proteins, a thorough comprehension of the molecular aspects of membrane fluidity is necessary to evaluate the arcane aspects of membrane-related cellular activities.
This book will be useful to scientists and researchers concerned with the molecular principles of cellular and organelle function. It also provides an appropriate background for Volume 3, Cellular Aspects and Disease Processes, and for subsequent discussion of the relationship of membrane fluidity to environmental parameters, drugs, anesthetics, and other exogenous agents.
Contributors Preface Contents of Volume 1
- Definitions, Explanations, and an Overview of Membrane Fluidity References
- Biomembrane Fluidity: The Concept and Its Development The Concept of Biomembrane Fluidity Fluidity and Lipid Dynamics Fluidity and Its Modulation by Cholesterol Fluidity and Protein Dynamics Intrinsic Protein-Lipid Interactions The Restriction of Movement and Fluidity of Biomembranes Conclusions References
- Lipid Phase Transitions and Mixtures Introduction First-Order Phase Transitions Structures of Lipid Phases The Gel to Liquid-Crystalline Phase Transition Thermodynamics of the Lamellar Phase Lipid Mixtures Addendum References
- The Hydrophobic and Electrostatic Effects of Proteins on Lipid Fluidity and Organization Introduction Evidence for Hydrophobic and Electrostatic Interactions of Extrinsic Membrane Proteins Dependence of Hydrophobic Interaction of Protein on Type of Lipid Direct Evidence for Conformational Changes of Protein upon Binding to Lipid Conclusion References
- Lateral Phase Separations and the Cell Membrane Introduction Basic Lipid Arrangement Cation Effects Integral Proteins and the Phase Separation Cholesterol Temperature Peripheral Proteins and the Phase Separation Cell Surface Recognition Events Summary References
- Phospholipid Transfer Proteins and Membrane Fluidity Introduction Survey of Phospholipid Transfer Proteins Mechanism of Protein-Catalyzed Phospholipid Transfer Relationship between Membrane Lipid Composition and Phospholipid Transfer Spontaneous Phospholipid Transfer Phospholipid Transfer Protein-Lipid Interactions References
- lonotropic Effects on Phospholipid Membranes: Calcium/Magnesium Specificity in Binding, Fluidity, and Fusion Introduction T
- No. of pages:
- © Academic Press 1983
- 1st November 1983
- Academic Press
- eBook ISBN: