General Principles

General Principles

1st Edition - November 1, 1983

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  • Editor: Ronald Aloia
  • eBook ISBN: 9780323157636

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Membrane Fluidity in Biology, Volume 2: General Principles provides an introduction to the fundamental concepts of membrane fluidity. Key topics discussed include lateral phase separations and phase transitions; hydrophobic and electrostatic effects of membrane lipid-protein interactions; isothermal phase transitions and the effects of ionic factors; and the influence of such components as cholesterol, phospholipids, fatty acids, and cellular water on the parameters of membrane fluidity. Each of these topics is elaborated in detail to provide a unique insight into the factors influencing the thermal molecular motions of membrane components, and hence cellular membrane function. Because such activities as membrane transport, enzyme kinetics, and receptor function are modulated by the physical state of the membrane lipids and proteins, a thorough comprehension of the molecular aspects of membrane fluidity is necessary to evaluate the arcane aspects of membrane-related cellular activities. This book will be useful to scientists and researchers concerned with the molecular principles of cellular and organelle function. It also provides an appropriate background for Volume 3, Cellular Aspects and Disease Processes, and for subsequent discussion of the relationship of membrane fluidity to environmental parameters, drugs, anesthetics, and other exogenous agents.

Table of Contents

  • Contributors


    Contents of Volume 1

    1. Definitions, Explanations, and an Overview of Membrane Fluidity


    2. Biomembrane Fluidity: The Concept and Its Development

    The Concept of Biomembrane Fluidity

    Fluidity and Lipid Dynamics

    Fluidity and Its Modulation by Cholesterol

    Fluidity and Protein Dynamics

    Intrinsic Protein-Lipid Interactions

    The Restriction of Movement and Fluidity of Biomembranes



    3. Lipid Phase Transitions and Mixtures


    First-Order Phase Transitions

    Structures of Lipid Phases

    The Gel to Liquid-Crystalline Phase Transition

    Thermodynamics of the Lamellar Phase

    Lipid Mixtures



    4. The Hydrophobic and Electrostatic Effects of Proteins on Lipid Fluidity and Organization


    Evidence for Hydrophobic and Electrostatic Interactions of Extrinsic Membrane Proteins

    Dependence of Hydrophobic Interaction of Protein on Type of Lipid

    Direct Evidence for Conformational Changes of Protein upon Binding to Lipid



    5. Lateral Phase Separations and the Cell Membrane


    Basic Lipid Arrangement

    Cation Effects

    Integral Proteins and the Phase Separation



    Peripheral Proteins and the Phase Separation

    Cell Surface Recognition Events



    6. Phospholipid Transfer Proteins and Membrane Fluidity


    Survey of Phospholipid Transfer Proteins

    Mechanism of Protein-Catalyzed Phospholipid Transfer

    Relationship between Membrane Lipid Composition and Phospholipid Transfer

    Spontaneous Phospholipid Transfer

    Phospholipid Transfer Protein-Lipid Interactions


    7. lonotropic Effects on Phospholipid Membranes: Calcium/Magnesium Specificity in Binding, Fluidity, and Fusion


    Thermotropic and lonotropic Phase Transitions in Phospholipid Membranes

    Binding of Ca2+ and Mg2+ to Phospholipid Membranes

    lonotropic Phase Separations in Phospholipid Mixtures

    Intermembrane Interactions

    Calcium/Magnesium Specificity in Membrane Fusion

    Implications for Biological Membranes


    8. The Effect of the Proton and of Monvalent Cations on Membrane Fluidity


    The Effect of Structural Variation within the Phospholipid Molecule

    The Effect of Protons

    The Effect of Monovalent Cations

    Concluding Remarks


    9. Membrane Fluidity and Cytoplasmic Viscosity






Product details

  • No. of pages: 286
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: November 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323157636

About the Editor

Ronald Aloia

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