Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.

Table of Contents

List of contributors. Preface. Section I - Techniques in Analysis of Gene Expression. 1. The gene knockout technology for the analysis of learning and memory, and neural development. 2. Molecular biology of transmissible spongiform encephalopathies. 3. Molecular genetic analysis of myelin deficiency and cerebellar ataxia. 4. Gene expression of serotonergic neurons in the central nervous system: molecular and developmental analysis. Section II - Signal Transduction and Gene Expression. 5. The involvement of PKC and multifunctional CaM kinase II of post-synaptic neuron in induction and maintenance of long-term potentiation (T.P. Feng). 6. Neuronal calcium channels encoded by the &agr;1A subunit and their contribution to excitatory synaptic transmission in the CNS. 7. Synaptic vesicle proteins and regulated exocytosis. 8. The molecular organization of voltage-dependent K+ channels in vivo. 9. Decoding Ca2+ signals to the nucleus by multifunctional CaM kinase. 10. Kainate-induced changes in gene expression in the rat hippocampus. 11. Mechanisms of neuronal plasticity as analyzed at the single cell level. Section III - Development, Differentiation, and Aging. 12. Plasticity and commitment in the developing cerebral cortex. 13. Growth factors in the CNS and their effects on oligodendroglia. 14. Social control of cell size: males and females are different. 15. The differentiation and function of the touch receptor neurons of Caenorhabditis elegans. 16. Functions of the L2/HNK-1 carbohydrate in the nervous system. 17. Neurotrophic factors and their receptors. 18. Induction of non-catalytic TrkB neurotrophin receptors during lesion-induced synaptic rearrangement in the adult rat hippocampus. 19. Plasticity of developing neuromuscular synapses. 20. A RT-PCR study of gene expression in a mechanical injury model. 21. Stimulation of phospholipase A2 expression in rat cultured


No. of pages:
© 1995
Elsevier Science
Print ISBN:
Electronic ISBN: