Gastrointestinal Endocrinology

Gastrointestinal Endocrinology

Receptors and Post-Receptor Mechanisms

1st Edition - June 28, 1990

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  • Editor: James Thompson
  • eBook ISBN: 9780323146425

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Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms provides information pertinent to the fundamental aspects of receptors and post-receptor mechanisms. This book discusses a variety of topics, including normal and neoplastic growth, molecular biology and genetics, and actions of gut hormones and their clinical importance. Organized into 37 chapters, this book begins with an overview of the initial step in the interaction of a gastrointestinal peptide with its target cell. This text then examines the concept that the receptor proteins are a major control mechanism by which a cell engineers the effects of a hormone. Other chapters consider the epidermal growth factor (EGF), which is a heat-stable polypeptide that exerts both short- and long-term regulatory effects on various cellular processes. This book discusses as well the developments in the ability to measure the concentration of ionized calcium in cells. The final chapter deals with the hormonal mechanisms in gallbladder motility. This book is a valuable resource for biochemists.

Table of Contents

  • Contributors




    1. Role of Receptors in Expression of Gastrointestinal Hormone Function

    2. Gastrointestinal Hormone Receptors and Receptor-Regulation

    3. Multifunctional Role of the Epidermal Growth Factor Receptor in the Regulation of Cell Growth

    4. Regulation of Intracellular Calcium Release and Calcium Uptake by Inositol 1,4,5-trisphosphate in Exocrine Glands

    5. Cellular Calcium and Phospholipid Metabolism Mediate Pancreatic Enzyme Secretion

    6. Heterogeneity of Receptors and Signal Transduction Pathways in Smooth Muscle Cells of the Gut

    7. Biochemical Characterization of Receptors for the Cholecystokinin Family of Hormones

    8. Cholecystokinin Receptor Antagonists: Ability to Distinguish Various Classes of Cholecystokinin Receptors

    9. Cholecystokinin Gene Expression

    10. Human and Mouse Amylase Genes in Transgenic Mice

    11. Studies on Gastrin Posttranslational Processing

    12. Cell-Specific Expression and Processing of Procholecystokinin and Progastrin

    13. Pancreatic Polypeptide, Peptide YY, and Secretin Gene Expression

    14. Modern Imaging at the Cellular Level

    15. Gastrointestinal Peptides and Autocrine Growth Effects

    16. Primary Cultures of Pancreatic Acinar Cells

    17. Trophic Effects of Cholecystokinin on the Exocrine Pancreas

    18. Involvement of Somatostatin in Pancreatic Growth

    19. Pancreatic Adaptation Involves Regulation of Gene Expression by Cholecystokinin

    20. Growth of Normal and Malignant Gastrointestinal Cells in Culture: Differential Responses to Peptides

    21. Effect of Gastrointestinal Hormones on Neoplastic Growth

    22. Gastrin is a Hormonal Stimulant of the Intestinal, Gastric and Cephalic Phases of Acid Secretion in Dogs

    23. Pancreatic Enzymes in Feedback Regulation of Cholecystokinin Release

    24. Bile Salts in Cholecystokinin Feedback

    25. Neuronal Actions of Cholecystokinin

    26. The Role of Pancreatic Polypeptide in Glucose Metabolism

    27. Immunologie and Biologic Properties of Glucagon-Like Peptide-1 (GLP-1)

    28. Peptide YY Release and Actions

    29. Receptor Mediated Biologic Actions of Cholecystokinin

    30. The Cell Biology of Acute Pancreatitis

    31. Somatostatin: Treatment of Gut Endocrinopathies and a Mechanism of Action

    32. Cytoprotective Effects of Somatostatin on Experimental Diabetes

    33. Actions of Parathyroid Hormone on the Gut

    34. Inhibitory Mechanisms of the Exocrine Pancreas

    35. Autocrine/Paracrine Growth Factors of Human Malignancies

    36. Clinical Syndromes of Gut Hormones

    37. Hormonal Mechanisms in Gallbladder Motility


Product details

  • No. of pages: 546
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: June 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323146425

About the Editor

James Thompson

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