Gap Junctions

1st Edition

Editors: J.E. Hall Guido Zampighi R.M. Davis
Hardcover ISBN: 9780444898715
eBook ISBN: 9780444599841
Imprint: Elsevier Science
Published Date: 8th April 1993
Page Count: 356
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Table of Contents

Prologue. Contributors. Part I. The Connexin Protein Family Divergent properties of different connexins expressed in Xenopus oocytes. Identification of novel connexins by reduced stringency hybridization and PCR amplification using degenerate primers. Affinities between connexins. Expression of Cx43 in rat and mouse liver. The mouse connexin gene family. Part II. Structure Atomic force microscopy of gap junctions. Structure and design of cardiac gap-junction membrane channels. Biochemistry of gap-junction channels. In vitro assembly of lens gap junctions. Part III. Hemichannels Connexins, gap junction proteins, and ATP-induced pores in macrophages. Connexin-46 forms gap-junctional hemichannels in Xenopus oocytes. Solitary retinal horizontal cells express hemi-gap-junction channels. Part IV. Biophysics Molecular and biophysical properties of the connexins from developing chick heart. Multiple channel conductance states in gap junctions. Comparison of voltage dependent properties of gap junctions in hepatocytes and in Xenopus oocytes expressing Cx32 and Cx26. Influence of lipophilic compounds on gap-junction channels. Evidence for heterogeneous channel behavior in gap junctions. Unmasking electrophysiological properties of connexins 32 and 43. Part V. Role of Gap Junctions in Various Tissues and Organisms Nervous System. Plasticity of gap junctions at mixed synapses. Regulation of connexin 32 in motor networks of mammalian neurons. Ocular lens and heart. Channel reconstitution from lens MP70 enriched preparations. Does MIP play a role in cell-cell communication? Gap junction channel reconstitution in artificial bilayers and evidence for calmodulin binding sites in MIP26 and connexins from rat heart, liver and Xenopus embryo. Expression of multiple connexins by cells of the cardiovascular system and lens. The developmental expressio


Gap junctions are present in nearly all tissues, regardless of their embronic origin and have long been of great interest to scientists from many different disciplines. The international meeting on which this book is based brought together 157 scientists from 12 countries and almost as many scientific disciplines. The papers presented at the meeting were reviewed and updated prior to publication in this book. The seven parts of the book progress from general topics to the more specific ones (role of gap junctions in various tissues, regulation and biochemistry, and cancer).


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© Elsevier Science 1993
Elsevier Science
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About the Editors

J.E. Hall Editor

Affiliations and Expertise

University of California, Irvine, California, USA

Guido Zampighi Editor

Affiliations and Expertise

University of California, Los Angeles, California, USA

R.M. Davis Editor

Affiliations and Expertise

University of California, Los Angeles, California, USA