1st Edition - December 31, 2012

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  • Editor: Paul Wassarman
  • eBook ISBN: 9780123914378
  • Hardcover ISBN: 9780124160248

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This new volume of Current Topics in Developmental Biology covers the area of gametogenesis, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells.

Key Features

  • Covers the area of gametogenesis
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

  • Series Page



    Chapter One. Cohesin in Gametogenesis

    1 Introduction

    2 Meiosis I

    3 Meiosis II

    4 Cohesin Loading and Associated Factors

    5 Role of Cohesin in Checkpoint Mechanisms

    6 Centromeres, Kinetochores, and Centrioles

    7 Errors and Age Effects in Oocytes

    8 Perspective/Questions


    Chapter Two. Genomic Imprinting Is a Parental Effect Established in Mammalian Germ Cells

    1 Introduction

    2 Discovery of Genomic Imprinting

    3 Expression of Imprinted Genes

    4 Coregulation of the Imprinted Genes in Clusters

    5 DNA Methylation

    6 DNA Demethylation

    7 Cycle of DMR Methylation

    8 Establishment of the DNA Methylation Imprint

    9 Maintenance of the DNA Methylation Imprint

    10 Imprinting Control Mechanisms

    11 Igf2–H19 Imprinted Region

    12 Igf2r Imprinted Region

    13 Dlk1–Gtl2 Imprinted Region

    14 Snrpn Imprinted Region

    15 Imprinting-Related Human Diseases

    16 Macro ncRNA in Imprinting Control

    17 Imprinting in Pluripotent Stem Cells

    18 Evolution of Imprinting

    19 Conclusions


    Chapter Three. The Identity and Fate Decision Control of Spermatogonial Stem Cells

    1 Introduction

    2 Heterogeneity of Isolated Type A Spermatogonia and the SSC Population Size in the Mouse Testis

    3 Cell-Surface and Intracellular SSC Markers

    4 Balance Between Self-Renewal and Commitment

    5 The Point of No Return: When and How Does SSC Commitment Start and End?

    6 Concluding Remarks


    Chapter Four. Germline Stem Cells

    1 Spermatogonial Stem Cells

    2 Female Germline Stem Cells


    Chapter Five. LINCing the Nuclear Envelope to Gametogenesis

    1 Introduction

    2 LINC Complexes Are Versatile Connectors

    3 General Features of the Nucleocytoplasmic Intersection in Germ Cells

    4 SUN–KASH Bridges Drive Meiosis

    5 LINCs in Sperm Head Formation

    6 Concluding Remarks


    Chapter Six. Small RNAs in Germline Development

    1 Introduction: Germline Development and Small Regulatory RNAs

    2 Small RNAs in Germ Cells

    3 Small RNAs in Germ Cell Tumor Formation

    4 Conclusion


    Chapter Seven. The Control of Meiotic Maturation in Mammalian Oocytes

    1 Introduction

    2 Control of GV Arrest

    3 Control of Meiosis I

    4 Concluding Remarks


    Chapter Eight. Signaling Modalities During Oogenesis in Mammals

    1 Introduction

    2 Framing and Qualifying the Complexity of Oogenesis

    3 Cell Contact-Mediated Signaling

    4 Receptor–Ligand Interactions

    5 Autocrine–Paracrine Signaling Pathways

    6 Heterocellular Contact via TZPs

    7 RTKs and Cortical Maturation

    8 Summary and Conclusions


    Chapter Nine. Biogenesis of the Mouse Egg’s Extracellular Coat, the Zona Pellucida

    1 Introduction to the Mammalian Egg’s Zona Pellucida

    2 Appearance of the Mouse Egg’s ZP During Oogenesis

    3 Nature of Mouse ZP Glycoproteins

    4 Genes Encoding Mouse ZP Glycoproteins

    5 Synthesis of ZP Glycoproteins by Mouse Oocytes

    6 Molecular Aspects of Synthesis of Mouse ZP Glycoproteins

    7 Elimination of Synthesis of Mouse ZP Glycoproteins

    8 Secretion and Assembly of Mouse ZP Glycoproteins


    Chapter Ten. Molecular Changes During Egg Activation

    1 Introduction

    2 Ion Levels

    3 Changes in Proteome Composition

    4 mRNA Degradation

    5 Summary


    Chapter Eleven. The Role of the Double Bromodomain-Containing BET Genes During Mammalian Spermatogenesis

    1 Introduction

    2 Mammalian BET Gene Expression During Spermatogenesis

    3 BRDT Is Required for Proper Spermatogenesis and Male Fertility

    4 BRDT and Regulation of Transcription and Posttranscriptional Processing During Spermatogenesis

    5 BRDT and Later Stages of Spermiogenesis

    6 BET Inhibition as a Possible Contraceptive

    7 Conclusions


    Chapter Twelve. DMRT Genes in Vertebrate Gametogenesis

    1 Background

    2 DMRT1 in the Mammalian Fetal Gonad

    3 DMRT1 in Human Testicular Germ Cell Cancer

    4 DMRT1 in the Postnatal Mammalian Gonad

    5 DMRT1 in Supporting Cells of the Mammalian Testis

    6 DMRT1 in the Mammalian Ovary

    7 DMRT7 and Sex Chromatin

    8 DMRT1 in Other Vertebrates

    9 Conclusions


    Chapter Thirteen. RanBPM, a Scaffolding Protein for Gametogenesis

    1 Introduction

    2 Protein Structure

    3 Function Outside the Reproductive System

    4 Phenotype of RanBPM-Deficient Mice

    5 Expression in the Reproductive System

    6 RanBPM Is Dispensable for Primordial Germ Cell Migration

    7 Function of RanBPM During Postnatal Testis Development

    8 Meiotic Arrest in Mice Deficient for RanBPM

    9 Role of RanBPM in the Adult Gonad

    10 Cell-Autonomous Function of RanBPM

    11 Conclusion


    Further reading

    Chapter Fourteen. K+ and Cl− Channels and Transporters in Sperm Function

    1 Introduction

    2 Epididymal Maturation

    3 Capacitation

    4 Acrosome Reaction

    5 Final Remarks



Product details

  • No. of pages: 456
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: December 31, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123914378
  • Hardcover ISBN: 9780124160248

About the Serial Volume Editor

Paul Wassarman

Paul Wassarman
Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.

Affiliations and Expertise

Icahn School of Medicine, Mount Sinai, USA

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