Description

This new volume of Current Topics in Developmental Biology covers the area of gametogenesis, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells.

Key Features

  • Covers the area of gametogenesis
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells

Readership

Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

Series Page

Contributors

Preface

Chapter One. Cohesin in Gametogenesis

1 Introduction

2 Meiosis I

3 Meiosis II

4 Cohesin Loading and Associated Factors

5 Role of Cohesin in Checkpoint Mechanisms

6 Centromeres, Kinetochores, and Centrioles

7 Errors and Age Effects in Oocytes

8 Perspective/Questions

References

Chapter Two. Genomic Imprinting Is a Parental Effect Established in Mammalian Germ Cells

1 Introduction

2 Discovery of Genomic Imprinting

3 Expression of Imprinted Genes

4 Coregulation of the Imprinted Genes in Clusters

5 DNA Methylation

6 DNA Demethylation

7 Cycle of DMR Methylation

8 Establishment of the DNA Methylation Imprint

9 Maintenance of the DNA Methylation Imprint

10 Imprinting Control Mechanisms

11 Igf2–H19 Imprinted Region

12 Igf2r Imprinted Region

13 Dlk1–Gtl2 Imprinted Region

14 Snrpn Imprinted Region

15 Imprinting-Related Human Diseases

16 Macro ncRNA in Imprinting Control

17 Imprinting in Pluripotent Stem Cells

18 Evolution of Imprinting

19 Conclusions

References

Chapter Three. The Identity and Fate Decision Control of Spermatogonial Stem Cells

1 Introduction

2 Heterogeneity of Isolated Type A Spermatogonia and the SSC Population Size in the Mouse Testis

3 Cell-Surface and Intracellular SSC Markers

4 Balance Between Self-Renewal and Commitment

5 The Point of No Return: When and How Does SSC Commitment Start and End?

6 Concluding Remarks

References

Chapter Four. Germline Stem Cells

1 Spermatogonial Stem Cells

2 Female Germline Stem Cells

References

Chapter Five. LINCing the Nuclear Envelope to Gametogenesis

1 Introduction

2 LINC Complexes Are Versatile Con

Details

No. of pages:
456
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780123914378
Print ISBN:
9780124160248

About the serial-volume-editor

Paul Wassarman

Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.

Affiliations and Expertise

Icahn School of Medicine at Mount Sinai, USA