Description

This new volume of Current Topics in Developmental Biology covers the area of gametogenesis, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells.

Key Features

  • Covers the area of gametogenesis
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells

Readership

Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

Series Page

Contributors

Preface

Chapter One. Cohesin in Gametogenesis

1 Introduction

2 Meiosis I

3 Meiosis II

4 Cohesin Loading and Associated Factors

5 Role of Cohesin in Checkpoint Mechanisms

6 Centromeres, Kinetochores, and Centrioles

7 Errors and Age Effects in Oocytes

8 Perspective/Questions

References

Chapter Two. Genomic Imprinting Is a Parental Effect Established in Mammalian Germ Cells

1 Introduction

2 Discovery of Genomic Imprinting

3 Expression of Imprinted Genes

4 Coregulation of the Imprinted Genes in Clusters

5 DNA Methylation

6 DNA Demethylation

7 Cycle of DMR Methylation

8 Establishment of the DNA Methylation Imprint

9 Maintenance of the DNA Methylation Imprint

10 Imprinting Control Mechanisms

11 Igf2–H19 Imprinted Region

12 Igf2r Imprinted Region

13 Dlk1–Gtl2 Imprinted Region

14 Snrpn Imprinted Region

15 Imprinting-Related Human Diseases

16 Macro ncRNA in Imprinting Control

17 Imprinting in Pluripotent Stem Cells

18 Evolution of Imprinting

19 Conclusions

References

Chapter Three. The Identity and Fate Decision Control of Spermatogonial Stem Cells

1 Introduction

2 Heterogeneity of Isolated Type A Spermatogonia and the SSC Population Size in the Mouse Testis

3 Cell-Surface and Intracellular SSC Markers

4 Balance Between Self-Renewal and Commitment

5 The Point of No Return: When and How Does SSC Commitment Start and End?

6 Concluding Remarks

References

Chapter Four. Germline Stem Cells

1 Spermatogonial Stem Cells

2 Female Germline Stem Cells

References

Chapter Five. LINCing the Nuclear Envelope to Gametogenesis

1 Introduction

2 LINC Complexes Are Versatile Con

Details

No. of pages:
456
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780124160248
Electronic ISBN:
9780123914378