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Description
Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians.
Key Features
* Discusses the neuropathology of the GABA system in autism
* Presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism
* Includes information on the shared genetic risk factors between autism and major mental disorders
* Foreword by Eugene Roberts
Readership
Neurologists, neurosurgeons, neuroradiologists and other neuroscientists who are dedicated to the advancement of techniques used to evaluate the neurobiology of autism.
Table of Contents
Foreword by Eugene Roberts
Autism: neuropathology, alterations of the GABAergic system, and animal models
The role of GABA in the early neuronal development
GABAergic signaling in the developing cerebellum
Insights into GABA functions in the developing cerebellum
Role of GABA in the Mechanism of the Onset of Puberty in Non-Human Primates
Rett Syndrome: A Rosetta Stone for Understanding the Molecular Pathogenesis of Autism
GABAergic Cerebellar System in Autism: A Neuropathological and Developmental Perspective
Reelin Glycoprotein in Autism and Schizophrenia
Is there a connection between autism, Prader-Willi syndrome, catatonia and GABA?
The role of GABA in prenatal alcohol exposure
Effects of secretin on extracellular GABA and other amino acid concentractions in the rat hippocampus
Predicted therapeutic role of secretin and oxytocin in augism: Implications for treatment of mental illness
Immunological Findings in Autism
Correlates of psychomotor symptoms in autism
Gabrb3 Gene Deficient Mice: A Potential Model of Autism Spectrum Disorder
The Reeler Mouse: Anatomy of a Mutant
GABA-A receptor mutations in epilepsy and other disorders
Shared chromosomal susceptibility regions between autism and other mental disorders
Details
- No. of pages:
- 512
- Language:
- English
- Copyright:
- © 2005
- Published:
- 7th December 2005
- Imprint:
- Academic Press
- eBook ISBN:
- 9780080918952
- Print ISBN:
- 9780123668721
About the serial-volume-editor
Dirk Dhossche
Affiliations and Expertise
Department of Psychiatry & Human Behavior, University of Mississippi Medical Center, Jackson, USA
Reviews
Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians.