G Protein-Coupled Receptors - Part B

G Protein-Coupled Receptors - Part B

1st Edition - February 1, 2023

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  • Editor: Arun K. Shukla
  • Hardcover ISBN: 9780323994347

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Description

G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more.

Key Features

  • Covers a broad range of topics related to GPCR activation and signaling
  • Provides several receptor systems, with an emphasis on emerging paradigms
  • Includes different processes and model systems, with a focus on GPCRs

Readership

Scientists interested in learning about the latest developments in the field of GPCR biology and drug discovery

Table of Contents

  • Preface
    Arun K. Shukla
    1. Adhesion G protein-coupled receptors: Structure and functions
    Doreen Thor and Ines Liebscher
    2. Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle
    Hye Ji J. Kim, Ayat Zagzoog, Tallan Black, Sarah L. Baccetto and Robert B. Laprairie
    3. Probing the orphan receptors: Tools and directions
    Luca Franchini and Cesare Orlandi
    4. Asymmetric activation of Class C GPCRs
    Hongnan Liu, Yanjun Li and Yang Gao
    5. Common and selective signal transduction mechanisms of GPCRs
    Berkay Selçuk and Ogun Adebali
    6. Appreciating the potential for GPCR crosstalk with ion channels
    Amy Davies and Alejandra Tomas
    7. Recent advances in calcium-sensing receptor structures and signaling pathways
    Caroline M. Gorvin
    8. Structural insights into promiscuous GPCR-G protein coupling
    Angela Carrión-Antolí, Jorge Mallor-Franco, Sandra Arroyo-Urea and Javier García-Nafría
    9. Opioid signaling and design of analgesics
    Barnali Paul, Sashrik Sribhashyam and Susruta Majumdar

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: February 1, 2023
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323994347

About the Serial Volume Editor

Arun K. Shukla

Arun K. Shukla
Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.

Affiliations and Expertise

Indian Institute of Technology, Kanpur, India

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