G Protein-Coupled Receptors in Health and Disease, Part B

G Protein-Coupled Receptors in Health and Disease, Part B

1st Edition - September 19, 2009

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  • Editor: Ya-Xiong Tao
  • eBook ISBN: 9780080911946
  • Hardcover ISBN: 9780123747563

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G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

Key Features

* This series provides a forum for discussion of new discoveries, approaches, and ideas
* Contributions from leading scholars and industry experts
* Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine

Table of Contents

  • 1. Diseased G protein-coupled receptors: An Introduction

    Ya-Xiong Tao

    2. GPR56 and its related diseases

    Xianhua Piao and Ze Tian

    3. GnRHR mutations and hypogonadotropic hypogonadism

    Nicholas de Roux

    4. LHR mutations and reproductive disorders

    Deborah L. Segaloff

    5. FSHR mutations and reproductive disorders

    Ya-Xiong Tao and Deborah L. Segaloff

    6. V2R mutations and nephrogenic diabetes insipidus

    Daniel G. Bichet

    7. Calcium-sensing receptor mutations

    Geoffrey N. Hendy

    8. Diseases caused by prostacyclin receptor mutations

    John Hwa and Kathleen A Martin

Product details

  • No. of pages: 192
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: September 19, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080911946
  • Hardcover ISBN: 9780123747563

About the Serial Volume Editor

Ya-Xiong Tao

Dr. Ya-Xiong Tao is currently Professor of Physiology at Auburn University College of Veterinary Medicine in Auburn, Alabama, USA. He has been working on several G protein-coupled receptors, including gonadotropin receptors regulating reproduction, and melanocortin receptors regulating energy and glucose homeostasis. He has published extensively in peer-reviewed biomedical journals and obtained funding for his research from National Institutes of Health, American Diabetes Association and American Heart Association, among others. He has delivered numerous lectures at universities and research institutes in USA, Canada, China, India, and Mexico. He has edited ten volumes, including seven volumes in Progress in Molecular Biology and Translational Science. He teaches several courses, including Physiology, Receptorology, Genomics and Personalized Medicine, and Molecular Endocrinology, for veterinarian, graduate, and undergraduate Honors students.

Affiliations and Expertise

Professor of Physiology, College of Veterinary Medicine, Auburn University, AL, USA

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