Description

Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans.

Key Features

    • Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs.
    • Chapters are written by leading experts.

Readership

Molecular biologists and researchers in fields related to translational science

Table of Contents

Contributors

Preface

Chapter One. G Protein-Coupled Receptors as Regulators of Energy Homeostasis

Abbreviations

1 Introduction to G Protein-Coupled Receptors

2 Obesity and Current Treatments

3 Regulation of Energy Homeostasis in the Central Nervous System

4 Regulation of Energy Homeostasis by the GI Peptides

5 Regulation of Energy Homeostasis by Peptides from Endocrine Pancreas

6 Regulation of Energy Homeostasis by Orphan GPCRs

7 Regulation of Energy Homeostasis by GPCRs in Domestic Animals

8 Regulation of Energy Homeostasis by GPCRs in Lower Vertebrates

9 Genetics of Human Obesity

10 Summary

Acknowledgments

References

Chapter Two. Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis

1 Overview of the Ghrelin Receptor

2 The Ghrelin Receptor and Energy Metabolism

3 Strategies for Treatment of Obesity and Diabetes

4 Conclusion

Acknowledgments

References

Chapter Three. Obestatin Receptor in Energy Homeostasis and Obesity Pathogenesis

1 Two Proposed Obestatin Receptors

2 Obestatin and its Receptor(s) in Energy Homeostasis

Acknowledgments

References

Chapter Four. Melanocortin-3 Receptors and Metabolic Homeostasis

1 Introduction

2 The “Leptin-Melanocortin” Pathway: A Canonical Pathway Linking Energy Stores with Neural Outputs Regulating Adaptation to Energy Requirements

3 The Central Nervous Melanocortin System

4 Cloning of the Melanocortin Receptors

5 Melanocortin-3 Receptors in Metabolic Homeostasis

6 Conclusions and Future Directions

Acknowledgments

References

Chapter Five. Melanocortin-4 Receptor in Energy Homeostasis and Obesity Pathogenesis

1 The Melanocortin-4 Receptor Gene (MC4R)

2 From Rodent MC4R Models to Human Obesity

3

Details

No. of pages:
400
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780123869333
Electronic ISBN:
9780123869524

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal