Fungal Toxins

Fungal Toxins

A Comprehensive Treatise

1st Edition - January 28, 1971

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  • Editors: Alex Ciegler, Solomon Kadis, Samuel J. Ajl
  • eBook ISBN: 9781483215907

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Microbial Toxins, Volume VI: Fungal Toxins covers information on the evaluation of the chemical, biological, and biomedical aspects of the fungal toxins. The book discusses the historical structure chemistry, production, analysis, detoxification, biosynthesis, pharmacology, toxicology, and molecular biochemistry of aflatoxins and related compounds. The text also describes the isolation, analysis, production, chemistry, biological effects, and biogenesis of the ochratoxins, as well as the bioproduction, biosynthesis, and chemical properties of misclellaneous Aspergillus toxins. Various species of storage fungi, including yellowed rice toxins, luteoskyrin and related compounds, chlorine-containing compounds, citrinin, and citreoviridin are also considered. The book further tackles the physical and chemical properties and the biological activity of the rubratoxins; the biosynthesis and biochemical effects of patulin, penicillic acid, and other carcinogenic lactones; as well as the structure, production, biosynthesis, and biological effects of cyclopiazonic acid and related toxins. The text also encompasses bioproduction, properties, chemical structure, and biological activity of miscellaneous Penicillium toxins. Microbiologists, biochemists, epidemiologists, pharmacologists, toxicologists, medical students and people involved in other related fields will find the book useful.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Introductory Remarks

    Section A Aspergillus Toxins

    1. Aflatoxin and Related Compounds

    I. Introduction (Historical Structure Chemistry)

    II. Toxin-Producing Fungi

    III. Toxin-Affected Commodities

    IV. Production

    V. Analysis

    VI. Detoxification

    VII. Safety Procedures

    VIII. Biosynthesis

    IX. Pharmacology and Toxicology

    X. Molecular Biochemistry

    XI. Sterigmatocystin

    XII. Summary


    2. Ochratoxin and Other Dihydroisocoumarins

    I. Introduction

    II. Isolation, Analysis, and Production of the Ochratoxins

    III. Chemistry of the Ochratoxins

    IV. Biological Effects of Ochratoxin

    V. Biogenesis of the Ochratoxins and Their Relationship to Other Fungal Dihydroisocoumarins


    3. Miscellaneous Aspergillus Toxins

    I. Introduction

    II. Aspergillic Acid and Related Compounds

    III. Kojic Acid

    IV. β-Nitropropanoic Acid

    V. Endotoxins of Aspergillus fumigatus and Aspergillus flavus

    VI. Helvolic Acid

    VII. Oxalic Acid

    VIII. Tremorgenic Toxin from Aspergillus flavus

    IX. Fumagillin

    X. Fumigallin and Other Toluquinones


    General References Fumagillin

    Section B Penicillium Toxins

    4. Yellowed Rice Toxins Luteoskyrin and Related Compounds, Chlorine-Containing Compounds, and Citrinin


    5. The Rubratoxins, Toxic Metabolites of Penicillium rubrum Stoll

    I. Introduction

    II. Penicillium rubrum Stoll

    III. Growth and Toxin Production

    IV. The Rubratoxins, Anhydrides, and Lactols

    V. Chemical and Physical Properties

    VI. Relationship to Byssochlamic Acid

    VII. Biological Activity of the Rubratoxins


    6. Patulin, Penicillic Acid, and Other Carcinogenic Lactones

    I. Patulin

    II. Penicillic Acid

    III. Other Carcinogenic Lactones


    7. Cyclopiazonic Acid and Related Toxins

    I. Introduction

    II. Structural Elucidation of Cyclopiazonic Acid

    III. Production of Cyclopiazonic Acid and Related Indoles on Liquid Culture

    IV. Structural Elucidation of Metabolites Related to Cyclopiazonic Acid

    V. Biosynthesis of Cyclopiazonic Acid

    VI. Biological Effects of Cyclopiazonic Acid

    VII. Other Toxic Substances from Penicillium cyclopium Westling


    8. Miscellaneous Penicillium Toxins

    I. Introduction

    II. Mycophenolic Acid

    III. Decumbin

    IV. β-Nitropropanoic Acid, a Metabolite of Penicillium atrovenetum

    V. Tremorgenic-Diuretic Toxin from Penicillium cyclopium and Related Species

    VI. Toxins from Penicillium puberulum

    VII. Griseofulvin

    VIII. Xanthocillin X

    IX. Metabolites of Penicillium viridicatum and Closely Related Species


    Author Index

    Subject Index

Product details

  • No. of pages: 588
  • Language: English
  • Copyright: © Academic Press 1971
  • Published: January 28, 1971
  • Imprint: Academic Press
  • eBook ISBN: 9781483215907

About the Editors

Alex Ciegler

Solomon Kadis

Samuel J. Ajl

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