Antifungal Susceptibility Testing and Identification
Key points
Introduction
A note about nomenclature
Identification of fungal cultures
Susceptibility testing
Interpretation of broth microdilution assays
Commercial antifungal susceptibility methods
Molecular detection of antifungal resistance
Reporting considerations
Clinics Care points
Antifungals in Clinical Use and the Pipeline
Key points
Introduction
Polyenes
Novel polyene formulations in development
Antimetabolite
Azoles
New azoles in development
Echinocandins
New agents in development targeting glucan synthesis
Other novel agents in the pipeline (phase 2 or phase 3)
Summary
Clinics care points
Immunology of Fungal Infections
Key points
Innate and adaptive immunity to fungi
Susceptibility and immunity to Candida organisms
Susceptibility and immunity to aspergillosis
Susceptibility and immunity to Mucormycoses
Susceptibility and immunity to Cryptococcosis
Susceptibility and immunity to dimorphic fungi
Summary
Clinics care points
Candidemia and Invasive Candidiasis
Key points
Introduction
Diagnosis
Antifungal susceptibility testing
Clinical manifestations
Treatment
Clinics care points
Aspergillosis: Epidemiology, Diagnosis, and Treatment
Key points
Introduction
Mycology
Epidemiology and risk factors
Host susceptibility (genetic determinants)
Clinical manifestations
Noninvasive disease
Invasive disease
Diagnosis
Treatment
Antifungal resistance
Breakthrough infections
Summary
Clinics care points
Mucormycosis
Key points
Introduction
Microbiology
Epidemiology and host factors
Pathogenesis
Clinical presentation
Diagnosis
Management
Adjunctive management
Summary
Clinics care points
Disclosures
Coccidioidomycosis
Key points
Introduction
Epidemiology
Diagnosis
Clinical manifestations and management
Antifungal agents
Summary
Clinics care points
Histoplasmosis
Key points
Introduction
Epidemiology
Pathogenesis
Clinical manifestations
Diagnosis
Treatment
Summary
Clinics care points
Disclosure
Cryptococcosis
Key points
Introduction
The pathogens
Epidemiology and risk factors
Clinical manifestations
Diagnosis
Management
Summary
Clinics care points
Blastomycosis
Key points
Introduction
Mycology
Epidemiology
Pathogenesis
Clinical manifestations
Blastomycosis in special populations
Diagnosis
Treatment
Outcomes
Clinics care points
Disclosure statement
No. of pages: 240
Language: English
Edition: 1
Volume: 35-2
Published: May 31, 2021
Imprint: Elsevier
Hardback ISBN: 9780323812931
eBook ISBN: 9780323812948
LO
Luis Ostrosky-Zeichner
Affiliations and expertise
Associate Director, Infectious Diseases Fellowship, Director, Laboratory of Mycology Research, Medical Director for Epidemiology, Memorial Hermann Hospital Texas Medical Center
Professor, Infectious Diseases