Description

Fundamentals of Osteoporosis offers a concise yet comprehensive source of all the latest basic research related to osteoporosis in one reference work. Experts from all areas of osteoporosis research expose readers to genomic and proteomic analysis, and histopathology and imaging, as well cellular and molecular mechanisms relevant to assay development and drug discovery.

Key Features

  • Presents a concise yet comprehensive source of all the latest basic research related to osteoporosis in one reference work
  • Experts from all areas of osteoporosis research expose readers to genomic and proteomic analysis, histopathology and imaging, as well cellular and molecular mechanisms relevant to assay development and drug discovery

  • Clear, concise presentations by bone biologists of the cellular and molecular mechanisms underlying osteoporosis

Readership

Academic, medical, and pharmaceutical researchers in bone biology, endocrinology, and rheumatology; Medical researchers in pediatrics, internal medicine, orthopedics, primary care, geriatrics, obstetrics and gynecology, oncology, and nephrology.

Table of Contents

1) The Bone Organ System: Form and Function
Elise F. Morgan, George L. Barnes, and Thomas A. Einhorn

2) The Nature of Osteoporosis
Robert Marcus and Mary L. Bouxsein

3) Skeletal Heterogeneity and the Purposes of Bone Remodeling
A.M. Parfitt

4) Osteoblast Biology
Jane B. Lian and Gary S. Stein

5) Osteoclast Biology
Harry C. Blair, Scott Simonet, David L. Lacey, and Mone Zaidi

6) Osteocytes
Lynda F. Bonewald

7) The Regulatory Role of Matrix Proteins in Mineralization of Bone
Wei Zhu, Pamela G. Robey, and Adele L. Boskey

8) Development of the Skeleton
Sylvain Provot, Ernestina Schipani, Joy Wu, and Henry Kronenberg

9) Mouse Genetics as a Tool to Study Bone Development and Physiology
Clifford J. Rosen and Wesley G. Beamer

10) Parathyroid Hormone and Parathyroid Hormone-Related Protein
Robert A. Nissenson

11) Vitamin D: Biology, Action, and Clinical Implications
David Feldman, Peter J. Malloy, Aruna V. Krishnan, and Eva Balint

12) Regulation of Bone Cell Function by Estrogens
Barry S. Komm, Boris Cheskis, and Peter V.N. Bodine

13) Androgens and Skeletal Biology: Basic Mechanisms
Kristine M. Wiren

14) Phosphatonins
Peter J. Tebben, Theresa J. Berndt, and Rajiv Kumar

15) Wnt Signaling in Bone
Mark L. Johnson and Robert R. Recker

16) Cytokines and Bone Remodeling
Gregory R. Mundy, Babatunde Oyajobi, Gloria Gutierez, Julie Sterling, Susan Padalecki, Florent Elefterious, and Ming Zhao

17) Skeletal Growth Factors
Ernesto Canalis

18) Intercellular Communication during Bone Remodeling
T. John Martin, Gideon A. Roda

Details

No. of pages:
552
Language:
English
Copyright:
© 2010
Published:
Imprint:
Academic Press
Print ISBN:
9780123750983
Electronic ISBN:
9780123751089

About the authors

Robert Marcus

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.

Reviews

"This volume covers a comprehensive series of topics from structural parameters of bone to development of the skeleton, differentiation of the bone cell lineages, bone matrix and its mineralization, and the multiple kinds and levels of regulation that influence all of these. Well-covered are what I will call intrinsic regulators, e.g. the specific cells and their genes, transcription factors, matrix components, receptors, and extrinsic - even if locally produced - regulators, e.g. cytokines, hormones, growth factors, mechanical forces and the often complex regulatory networks that result and control development, growth and aging of bone and its turnover in health and disease.

There is something for expert and novice alike in this volume, and the chapters overall deal well with and make quite accessible the explosion of information that has occurred in all areas of bone biology. Beyond a couple of chapters that deal explicitly with important fundamental concepts and issues related to defining what osteoporosis or osteoporotic bone is, many of the others address how advances in basic bone biology have contributed to the understanding of osteoporosis and other bone diseases and have pointed towards new therapeutics.

The chapters appropriately and clearly identify gaps and directions for new research and almost all are nicely sprinkled with helpful tables, graphs, photomicrographs or other images, and summary schematics. This book provides authoritative and comprehensive coverage of most of the main current topics in bone biology."

--Jane E. Aubin, Ph.D., Professor, Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Canada