Fundamental Neuroscience

4th Edition

Editors: Larry Squire Darwin Berg Floyd E. Bloom Sascha du Lac Anirvan Ghosh Nicholas C. Spitzer
Hardcover ISBN: 9780123858702
eBook ISBN: 9780123858719
Imprint: Academic Press
Published Date: 6th November 2012
Page Count: 1152
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The fourth edition of Fundamental Neuroscience reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities.

The chapters include more than 100 boxes describing clinical conditions, techniques, and other special topics. Each chapter went through a thorough review process, giving the book an evenness of tone. The chapters are authored by outstanding working scientists who are experts on the topics they cover.

Key Features

  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • 30% new material including new chapters on dendritic development and spine morphogenesis, chemical senses, cerebellum, eye movements, circadian timing, sleep and dreaming, and consciousness
  • Accompanying website for students and instructors
  • Additional text boxes describing key experiments, disorders, methods, and concepts
  • More than 650 four-color illustrations, micrographs, and neuroimages
  • Multiple model system coverage beyond rats, mice, and monkeys
  • Extensively expanded index for easier referencing


Graduate students in neuroscience, neuroanatomy and neurophysiology, and neurobiology. The secondary market for this book is researchers in neuroscience primarily, but also in the related fields of psychology, cell biology, molecular biology, genetics and any other areas of science with cross over into neuroscience research.

Table of Contents

List of Boxes

Preface to the Fourth Edition

About the Editors


I: Fundamental Neuroscience

Chapter 1. Fundamentals of Neuroscience

A Brief History of Neuroscience

The Terminology of Nervous Systems is Hierarchical, Distributed, Descriptive, and Historically Based

Neurons and Glia Are Cellular Building Blocks of the Nervous System

Cellular Organization of the Brain

Organization of this Text

This Book is Intended for a Broad Range of Scholars of the Neurosciences

Clinical Issues in the Neurosciences

The Genomic Inventory is a Giant Step Forward

Neuroscience Today: a Communal Endeavor

The Creation of Knowledge

Responsible Conduct



Chapter 2. Basic Plan of the Nervous System


Evolution Highlights: General Organizing Principles

Development Reveals Basic Vertebrate Parts

The Basic Plan of Nervous System Connectivity

Overview of the Adult Mammalian Nervous System


II: Cellular and Molecular Neuroscience

Chapter 3. Cellular Components of Nervous Tissue


Specific Examples of Different Neuronal Types


Cerebral Vasculature


Chapter 4. Subcellular Organization of the Nervous System: Organelles and Their Functions

Axons and Dendrites: Unique Structural Components of Neurons

Protein Synthesis in Nervous Tissue

Cytoskeletons of Neurons and Glial Cells

Molecular Motors in the Nervous System

Building and Maintaining Cells of the Nervous System


Chapter 5. Membrane Potential and Action Potential

Membrane Potential

Passive Electrical Properties of the Neuron

Action Potential


Chapter 6. Neurotransmitters

Several Modes of Neu


No. of pages:
© Academic Press 2013
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Larry Squire

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd E. Bloom

Affiliations and Expertise

Scripps Research Institute, La Jolla, CA, USA

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Nicholas C. Spitzer

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA


Doody’s Core Titles 2013, Doody Enterprises


"Here in the fourth edition of this textbook, editors Squire, Berg, Bloom, du Lac, Ghosh, and Spitzer, all working scientists with backgrounds in various specialties in neuroscience, present extensive new material with all chapters updated and rewritten. The book is organized into seven sections with numerous chapters in each encompassing a comprehensive view of 21st century neuroscience…"--Reference & Research Book News, December 2013