Fundamental Neuroscience

Fundamental Neuroscience

3rd Edition - February 11, 2008

Write a review

  • Editors: Larry Squire, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh, Nicholas C. Spitzer, Larry R. Squire, Darwin Berg, Floyd Bloom, Sascha du Lac, Anirvan Ghosh, Nicholas Spitzer
  • eBook ISBN: 9780080561028

Purchase options

Purchase options
DRM-free (PDF, Mobi, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers!

Key Features

New to this edition:

  • 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness
  • Additional text boxes describing key experiments, disorders, methods, and concepts
  • Multiple model system coverage beyond rats, mice, and monkeys
  • Extensively expanded index for easier referencing

Readership

Graduate students in neuroscience, neuroanatomy and neurophysiology, and neurobiology. The secondary market for this book is researchers in neuroscience primarily, but also in the related fields of psychology, cell biology, molecular biology, genetics and any other areas of science with cross over into neuroscience research.

Table of Contents

  • Preface to the Third Edition

    About The Editors

    Contributors

    I: NEUROSCIENCE

    Chapter 1: Fundamentals of Neuroscience

    A BRIEF HISTORY OF NEUROSCIENCE

    THE TERMINOLOGY OF NERVOUS SYSTEMS IS HIERARCHICAL, DISTRIBUTED, DESCRIPTIVE, AND HISTORICALLY BASED

    NEURONS AND GLIA ARE CELLULAR BUILDING BLOCKS OF THE NERVOUS SYSTEM

    THE OPERATIVE PROCESSES OF NERVOUS SYSTEMS ARE ALSO HIERARCHICAL

    CELLULAR ORGANIZATION OF THE BRAIN

    ORGANIZATION OF THIS TEXT

    THIS BOOK IS INTENDED FOR A BROAD RANGE OF SCHOLARS OF THE NEUROSCIENCES

    CLINICAL ISSUES IN THE NEUROSCIENCES

    THE SPIRIT OF EXPLORATION CONTINUES

    THE GENOMIC INVENTORY IS A GIANT STEP FORWARD

    NEUROSCIENCE TODAY: A COMMUNAL ENDEAVOR

    THE CREATION OF KNOWLEDGE

    RESPONSIBLE CONDUCT

    SUMMARY

    Chapter 2: Basic Plan of the Nervous System

    INTRODUCTION

    EVOLUTION HIGHLIGHTS: GENERAL ORGANIZING PRINCIPLES

    DEVELOPMENT REVEALS BASIC VERTEBRATE PARTS

    THE BASIC PLAN OF NERVOUS SYSTEM CONNECTIVITY

    OVERVIEW OF THE ADULT MAMMALIAN NERVOUS SYSTEM

    II: CELLULAR AND MOLECULAR NEUROSCIENCE

    Chapter 3: Cellular Components of Nervous Tissue

    NEURONS

    SPECIFIC EXAMPLES OF DIFFERENT NEURONAL TYPES

    NEUROGLIA

    CEREBRAL VASCULATURE

    Chapter 4: Subcellular Organization of the Nervous System: Organelles and Their Functions

    AXONS AND DENDRITES: UNIQUE STRUCTURAL COMPONENTS OF NEURONS

    PROTEIN SYNTHESIS IN NERVOUS TISSUE

    CYTOSKELETONS OF NEURONS AND GLIAL CELLS

    MOLECULAR MOTORS IN THE NERVOUS SYSTEM

    BUILDING AND MAINTAINING NERVOUS SYSTEM CELLS

    Chapter 5: Electrotonic Properties of Axons and Dendrites

    TOWARD A THEORY OF NEURONAL INFORMATION PROCESSING

    BASIC TOOLS: CABLE THEORY AND COMPARTMENTAL MODELS

    SPREAD OF STEADY-STATE SIGNALS

    SPREAD OF TRANSIENT SIGNALS

    ELECTROTONIC PROPERTIES UNDERLYING PROPAGATION IN AXONS

    ELECTROTONIC SPREAD IN DENDRITES

    DYNAMIC PROPERTIES OF PASSIVE ELECTROTONIC STRUCTURE

    RELATING PASSIVE TO ACTIVE POTENTIALS

    Chapter 6: Membrane Potential and Action Potential

    MEMBRANE POTENTIAL

    ACTION POTENTIAL

    Chapter 7: Neurotransmitters

    SEVERAL MODES OF NEURONAL COMMUNICATION EXIST

    CHEMICAL TRANSMISSION

    CLASSICAL NEUROTRANSMITTERS

    NONCLASSICAL NEUROTRANSMITTERS

    PEPTIDE TRANSMITTERS

    UNCONVENTIONAL TRANSMITTERS

    SYNAPTIC TRANSMISSION IN PERSPECTIVE

    Chapter 8: Release of Neurotransmitters

    TRANSMITTER RELEASE IS QUANTAL

    EXCITATION–SECRETION COUPLING

    MOLECULAR MECHANISMS OF THE NERVE TERMINAL

    QUANTAL ANALYSIS: PROBING SYNAPTIC PHYSIOLOGY

    SHORT-TERM SYNAPTIC PLASTICITY

    Chapter 9: Neurotransmitter Receptors

    IONOTROPIC RECEPTORS

    G-PROTEIN COUPLED RECEPTORS

    Chapter 10: Intracellular Signaling

    SIGNALING THROUGH G-PROTEIN-LINKED RECEPTORS

    MODULATION OF NEURONAL FUNCTION BY PROTEIN KINASES AND PHOSPHATASES

    INTRACELLULAR SIGNALING AFFECTS NUCLEAR GENE EXPRESSION

    Chapter 11: Postsynaptic Potentials and Synaptic Integration

    IONOTROPIC RECEPTORS: MEDIATORS OF FAST EXCITATORY AND INHIBITORY SYNAPTIC POTENTIALS

    METABOTROPIC RECEPTORS: MEDIATORS OF SLOW SYNAPTIC POTENTIALS

    INTEGRATION OF SYNAPTIC POTENTIALS

    Chapter 12: Complex Information Processing in Dendrites

    STRATEGIES FOR STUDYING COMPLEX DENDRITES

    BUILDING PRINCIPLES STEP BY STEP

    AN AXON PLACES CONSTRAINTS ON DENDRITIC PROCESSING

    DENDRODENDRITIC INTERACTIONS BETWEEN AXONAL CELLS

    PASSIVE DENDRITIC TREES CAN PERFORM COMPLEX COMPUTATIONS

    SEPARATION OF DENDRITIC FIELDS ENHANCES COMPLEX INFORMATION PROCESSING

    DISTAL DENDRITES CAN BE CLOSELY LINKED TO AXONAL OUTPUT

    DEPOLARIZING AND HYPERPOLARIZING DENDRITIC CONDUCTANCES INTERACT DYNAMICALLY

    THE AXON HILLOCK-INITIAL SEGMENT ENCODES GLOBAL OUTPUT

    MULTIPLE IMPULSE INITIATION SITES ARE UNDER DYNAMIC CONTROL

    RETROGRADE IMPULSE SPREAD INTO DENDRITES CAN HAVE MANY FUNCTIONS

    EXAMPLES OF HOW VOLTAGE-GATED CHANNELS ENHANCE DENDRITIC INFORMATION PROCESSING

    DENDRITIC SPINES ARE MULTIFUNCTIONAL MICROINTEGRATIVE UNITS

    SUMMARY: THE DENDRITIC TREE AS A COMPLEX INFORMATION PROCESSING SYSTEM

    Chapter 13: Brain Energy Metabolism

    ENERGY METABOLISM OF THE BRAIN AS A WHOLE ORGAN

    TIGHT COUPLING OF NEURONAL ACTIVITY, BLOOD FLOW, AND ENERGY METABOLISM

    ENERGY-PRODUCING AND ENERGY-CONSUMING PROCESSES IN THE BRAIN

    BRAIN ENERGY METABOLISM AT THE CELLULAR LEVEL

    GLUTAMATE AND NITROGEN METABOLISM: A COORDINATED SHUTTLE BETWEEN ASTROCYTES AND NEURONS

    THE ASTROCYTE-NEURON METABOLIC UNIT

    III: NERVOUS SYSTEM DEVELOPMENT

    Chapter 14: Neural Induction and Pattern Formation

    NEURAL INDUCTION

    EARLY NEURAL PATTERNING

    REGIONALIZATION OF THE CENTRAL NERVOUS SYSTEM

    CONCLUSIONS

    Chapter 15: Cellular Determination

    ORIGINS AND GENERATION OF NEURONAL PROGENITORS

    SPATIAL AND TEMPORAL COORDINATES OF NEURONAL SPECIFICATION

    THE PRONEURAL AND NEUROGENIC GENES

    ASYMMETRIC CELL DIVISION AND CELL FATE

    CENTRAL NEURONS AND GLIA

    SENSORY NEURONS OF THE PERIPHERAL NERVOUS SYSTEM

    THE RETINA: A COLLABORATION OF INTRINSIC AND EXTRINSIC CUES

    COMBINATORIAL CODING IN MOTOR NEURONS DETERMINATION

    CELLS OF THE CEREBRAL CORTEX

    CONCLUSIONS

    Chapter 16: Neurogenesis and Migration

    INTRODUCTION

    DEVELOPMENT OF THE PERIPHERAL NERVOUS SYSTEM

    CELL MIGRATION IN THE CNS

    Chapter 17: Growth Cones and Axon Pathfinding

    GROWTH CONES ARE ACTIVELY GUIDED

    GUIDANCE CUES FOR DEVELOPING AXONS

    GUIDANCE CUES AND THE CONTROL OF CYTOSKELETAL DYNAMICS

    GUIDANCE AT THE MIDLINE: CHANGING RESPONSES TO MULTIPLE CUES

    Chapter 18: Target Selection, Topographic Maps, and Synapse Formation

    TARGET SELECTION

    DEVELOPMENT OF THE NEUROMUSCULAR SYNAPSE

    SYNAPSE FORMATION IN THE CENTRAL NERVOUS SYSTEM

    Chapter 19: Programmed Cell Death and Neurotrophic Factors

    CELL DEATH AND THE NEUROTROPHIC HYPOTHESIS

    THE ORIGINS OF PROGRAMMED CELL DEATH AND ITS WIDESPREAD OCCURRENCE IN THE DEVELOPING NERVOUS SYSTEM

    FUNCTIONS OF NEURONAL PROGRAMMED CELL DEATH

    MODES OF CELL DEATH IN DEVELOPING NEURONS

    THE MODE OF NEURONAL CELL DEATH REFLECTS THE ACTIVATION OF DISTINCT BIOCHEMICAL AND MOLECULAR MECHANISMS

    NERVE GROWTH FACTOR: THE PROTOTYPE TARGET-DERIVED NEURONAL SURVIVAL FACTOR

    THE NEUROTROPHIN FAMILY

    NEUROTROPHIN RECEPTORS

    SECRETION AND AXONAL TRANSPORT OF NEUROTROPHINS AND PRO-NEUROTROPHINS

    SIGNAL TRANSDUCTION THROUGH TRK RECEPTORS

    CYTOKINES AND GROWTH FACTORS HAVE MULTIPLE ACTIVITIES

    PROGRAMMED CELL DEATH IS REGULATED BY INTERACTIONS WITH TARGETS, AFFERENTS, AND NONNEURONAL CELLS

    THE ROLE OF PROGRAMMED CELL DEATH IN NEUROPATHOLOGY

    Chapter 20: Synapse Elimination

    OVERVIEW

    THE PURPOSE OF SYNAPSE ELIMINATION

    A STRUCTURAL ANALYSIS OF SYNAPSE ELIMINATION AT THE NEUROMUSCULAR JUNCTION

    A ROLE FOR INTERAXONAL COMPETITION AND ACTIVITY

    IS SYNAPSE ELIMINATION STRICTLY A DEVELOPMENTAL PHENOMENON?

    SUMMARY

    Chapter 21: Dendritic Development

    DYNAMICS OF DENDRITIC ARBOR DEVELOPMENT

    GENETIC CONTROL OF DENDRITE DEVELOPMENT IN DROSOPHILA

    EXTRACELLULAR REGULATION OF DENDRITIC DEVELOPMENT IN THE MAMMALIAN BRAIN

    EFFECT OF EXPERIENCE ON DENDRITIC DEVELOPMENT

    MECHANISMS THAT MEDIATE ACTIVITY-DEPENDENT DENDRITIC GROWTH

    CONVERGENCE AND DIVERGENCE

    CONCLUSION

    Chapter 22: Early Experience and Sensitive Periods

    BIRDSONG: LEARNED BY EXPERIENCE

    SOUND LOCALIZATION: CALIBRATED BY EARLY EXPERIENCE IN THE OWL

    PRINCIPLES OF DEVELOPMENTAL LEARNING

    IV: SENSORY SYSTEMS

    Chapter 23: Fundamentals of Sensory Systems

    SENSATION AND PERCEPTION

    RECEPTORS

    PERIPHERAL ORGANIZATION AND PROCESSING

    CENTRAL PATHWAYS AND PROCESSING

    SENSORY CORTEX

    SUMMARY

    Chapter 24: Chemical Senses: Taste and Olfaction

    TASTE

    OLFACTION

    PHEROMONE DETECTION

    Chapter 25: Somatosensory System

    PERIPHERAL MECHANISMS OF SOMATIC SENSATION

    NOCICEPTION, THERMORECEPTION, AND ITCH

    CNS COMPONENTS OF SOMATIC SENSATION

    THALAMIC MECHANISMS OF SOMATIC SENSATION

    THE PATH FROM NOCICEPTION TO PAIN

    THE TRIGEMINAL SYSTEM (Fig. 25.16)

    CORTICAL REPRESENTATION OF TOUCH

    Chapter 26: Audition

    EXTERNAL AND MIDDLE EAR

    THE COCHLEA

    THE AUDITORY NERVE

    CENTRAL NERVOUS SYSTEM

    Chapter 27: Vision

    OVERVIEW

    THE EYE AND THE RETINA

    P and M Pathways Have Different Response Properties

    M Cells Are Highly Sensitive to Contrast

    THE RETINOGENICULOCORTICAL PATHWAY

    V: MOTOR SYSTEMS

    Chapter 28: Fundamentals of Motor Systems

    BASIC COMPONENTS OF THE MOTOR SYSTEM

    MOTOR PROGRAMS COORDINATE BASIC MOTOR PATTERNS

    ROLES OF DIFFERENT PARTS OF THE NERVOUS SYSTEM IN THE CONTROL OF MOVEMENT

    CONCLUSION

    Chapter 29: The Spinal and Peripheral Motor System

    LOCOMOTION IS A CYCLE

    CONNECTING THE SPINAL CORD TO THE PERIPHERY

    SPINAL INTERNEURON NETWORKS

    DESCENDING CONTROL OF SPINAL CIRCUITS

    SENSORY MODULATION

    Chapter 30: Descending Control of Movement

    THE MEDIAL POSTURAL SYSTEM

    THE LATERAL VOLUNTARY SYSTEM

    SUMMARY

    Chapter 31: The Basal Ganglia

    BASAL GANGLIA ANATOMY

    GPi Is the Primary Basal Ganglia Output for Limb Movements

    SIGNALING IN BASAL GANGLIA

    THE EFFECT OF BASAL GANGLIA DAMAGE ON MOVEMENT

    FUNDAMENTAL PRINCIPLES OF BASAL GANGLIA OPERATION FOR MOTOR CONTROL

    BASAL GANGLIA PARTICIPATION IN NONMOTOR FUNCTIONS

    Chapter 32: Cerebellum

    ANATOMY AND PHYLOGENETIC DEVELOPMENT OF THE CEREBELLUM

    ASSESSING CEREBELLAR FUNCTION

    A Cerebellar Role in Rehabilitation? Functional Recovery through Relearning after Damage of Other Parts of the Nervous System

    Chapter 33: Eye Movements

    EYE MOVEMENTS ARE USED TO STABILIZE GAZE OR TO SHIFT GAZE

    THE MECHANICS OF MOVING THE EYES

    THE FUNDAMENTAL CIRCUITS FOR STABILIZING GAZE

    THE COMMANDS FOR SHIFTING GAZE ARE FORMED IN THE BRAIN STEM

    GAZE SHIFTS ARE CONTROLLED BY THE MIDBRAIN AND FOREBRAIN

    THE CONTROL OF GAZE SHIFTS INVOLVES HIGHER-ORDER PROCESSES

    THE CONTROL OF EYE MOVEMENTS CHANGES OVER TIME

    CONCLUSIONS

    VI: REGULATORY SYSTEMS

    Chapter 34: The Hypothalamus: An Overview of Regulatory Systems

    HISTORICAL PERSPECTIVE

    HYPOTHALAMIC CYTOARCHITECTURE

    FUNCTIONAL ORGANIZATION OF THE HYPOTHALAMUS

    EFFECTOR SYSTEMS OF THE HYPOTHALAMUS ARE HORMONAL AND SYNAPTIC

    Chapter 35: Central Control of Autonomic Functions: Organization of the Autonomic Nervous System

    SYMPATHETIC DIVISION: ORGANIZED TO MOBILIZE THE BODY FOR ACTIVITY

    PARASYMPATHETIC DIVISION: ORGANIZED FOR ENERGY CONSERVATION

    THE ENTERIC DIVISION OF THE ANS: THE NERVE NET FOUND IN THE WALLS OF VISCERAL ORGANS

    ANS PHARMACOLOGY: TRANSMITTER AND RECEPTOR CODING

    AUTONOMIC COORDINATION OF HOMEOSTASIS

    HIERARCHICALLY ORGANIZED ANS CIRCUITS IN THE CNS

    PERSPECTIVE: FUTURE OF THE AUTONOMIC NERVOUS SYSTEM

    SUMMARY AND GENERAL CONCLUSIONS

    Chapter 36: Neural Regulation of the Cardiovascular System

    AN ANATOMICAL FRAMEWORK

    A5 Cell Group

    A1 Cell Group

    ANATOMY AND CHEMICAL PROPERTIES OF AUTONOMIC PATHWAYS

    NETWORK GENERATORS

    SHORT-TERM CONTROL MECHANISMS

    REFLEX CONTROL OF THE CARDIOVASCULAR SYSTEM

    ARTERIAL BARORECEPTORS

    PERIPHERAL ARTERIAL CHEMORECEPTORS

    CARDIAC RECEPTORS

    ABDOMINAL VISCERAL REFLEXES

    Chapter 37: Neural Control of Breathing

    EARLY NEUROSCIENCE AND THE BRAIN STEM

    CENTRAL NERVOUS SYSTEM AND BREATHING

    WHERE ARE THE NEURONS GENERATING RESPIRATORY PATTERN?

    DISCHARGE PATTERNS OF RESPIRATORY NEURONS

    WHERE ARE THE NEURONS THAT GENERATE THE BREATHING RHYTHM?

    SENSORY INPUTS AND ALTERED BREATHING

    MECHANORECEPTORS IN THE LUNGS ADJUST BREATHING PATTERN AND INITIATE PROTECTIVE REFLEXES

    MODULATION AND PLASTICITY OF RESPIRATORY MOTOR OUTPUT

    SUPRAPONTINE STRUCTURES AND BREATHING

    Chapter 38: Food Intake and Metabolism

    CALORIC HOMEOSTASIS

    ROLE OF CALORIC HOMEOSTASIS IN CONTROL OF FOOD INTAKE

    CENTRAL CONTROL OF FOOD INTAKE

    NEUROPEPTIDES AND THE CONTROL OF FOOD INTAKE

    Chapter 39: Water Intake and Body Fluids

    BODY FLUID PHYSIOLOGY

    OSMOTIC HOMEOSTASIS

    VOLUME HOMEOSTASIS

    Chapter 40: Neuroendocrine Systems

    THE HYPOTHALAMUS IS A NEUROENDOCRINE ORGAN

    HYPOTHALAMIC RELEASING/INHIBITING HORMONES AND THEIR TARGETS

    THE HYPOTHALAMIC–ADENOHYPOPHYSIAL NEUROENDOCRINE SYSTEMS

    THE HYPOTHALAMIC-NEUROHYPOPHYSIAL SYSTEMS

    HORMONES AND THE BRAIN

    Chapter 41: Circadian Timekeeping

    OVERVIEW OF THE MAMMALIAN CIRCADIAN TIMING SYSTEM

    THE SUPRACHIASMATIC NUCLEI ARE THE SITE OF THE PRIMARY CIRCADIAN PACEMAKER IN MAMMALS

    A HIERARCHY OF CELL-AUTONOMOUS CIRCADIAN OSCILLATORS

    THE MOLECULAR BASIS FOR CIRCADIAN OSCILLATION IS A TRANSCRIPTIONAL FEEDBACK LOOP

    CIRCADIAN PHOTORECEPTION

    CIRCADIAN OUTPUT MECHANISMS

    DIVERSITY OF OUTPUT PATHWAYS LEADING TO PHYSIOLOGICAL RHYTHMS

    GENERAL SUMMARY

    Chapter 42: Sleep, Dreaming, and Wakefulness

    THE TWO STATES OF SLEEP: RAPID EYE MOVEMENT AND NONRAPID EYE MOVEMENT

    SLEEP IN THE MODERN ERA OF NEUROSCIENCE

    ANATOMY AND PHYSIOLOGY OF BRAIN STEM REGULATORY SYSTEMS

    MODELING THE CONTROL OF BEHAVIORAL STATE

    SLEEP HAS MULTIPLE FUNCTIONS

    Chapter 43: Reward, Motivation, and Addiction

    REWARD AND MOTIVATION

    ADDICTION

    VII: BEHAVIORAL AND COGNITIVE NEUROSCIENCE

    Chapter 44: Human Brain Evolution

    EVOLUTIONARY AND COMPARATIVE PRINCIPLES

    EVOLUTION OF PRIMATE BRAINS

    WHY BRAIN SIZE IS IMPORTANT

    CONCLUSIONS

    Chapter 45: Cognitive Development and Aging

    BRAIN DEVELOPMENT

    COGNITIVE DEVELOPMENT AND AGING: A LIFE SPAN PERSPECTIVE

    PATHOLOGICAL PROCESSES IN COGNITIVE DEVELOPMENT AND AGING

    Chapter 46: Visual Perception of Objects

    THE PROBLEM OF OBJECT RECOGNITION

    SUBSTRATES FOR OBJECT PERCEPTION AND RECOGNITION: EARLY EVIDENCE FROM BRAIN DAMAGE

    VISUAL PATHWAYS FOR OBJECT PROCESSING IN NONHUMAN PRIMATES

    NEURONAL PROPERTIES WITHIN THE OBJECT RECOGNITION PATHWAY

    FUNCTIONAL NEUROIMAGING AND ELECTROPHYSIOLOGY OF OBJECT RECOGNITION IN HUMANS

    PERCEPTION AND RECOGNITION OF SPECIFIC CLASSES OF OBJECTS

    OVERALL SUMMARY

    Chapter 47: Spatial Cognition

    NEURAL SYSTEMS FOR SPATIAL COGNITION

    PARIETAL CORTEX

    FRONTAL CORTEX

    HIPPOCAMPUS AND ADJACENT CORTEX

    SPATIAL COGNITION AND SPATIAL ACTION

    Chapter 48: Attention

    INTRODUCTION

    VARIETIES OF ATTENTION

    NEGLECT SYNDROME: A DEFICIT OF SPATIAL ATTENTION

    SINGLE UNIT RECORDING STUDIES IN NONHUMAN PRIMATES PROVIDE CONVERGENT EVIDENCE FOR A FRONTO-PARIETAL ATTENTIONAL CONTROL SYSTEM

    ATTENTION AFFECTS NEURAL ACTIVITY IN THE HUMAN VISUAL CORTEX IN THE PRESENCE AND ABSENCE OF VISUAL STIMULATION

    ATTENTION INCREASES SENSITIVITY AND BOOSTS THE CLARITY OF SIGNALS GENERATED BY NEURONS IN PARTS OF THE VISUAL SYSTEM DEVOTED TO PROCESSING INFORMATION ABOUT OBJECTS

    ATTENTION MODULATES NEURAL RESPONSES IN THE HUMAN LATERAL GENICULATE NUCLEUS

    THE VISUAL SEARCH PARADIGM HAS BEEN USED TO STUDY THE ROLE OF ATTENTION IN SELECTING RELEVANT STIMULI FROM WITHIN A CLUTTERED VISUAL ENVIRONMENT

    WHERE IS THE COMPUTATIONAL BOTTLENECK AS REVEALED BY SEARCH TASKS?

    NEURONAL RECEPTIVE FIELDS ARE A POSSIBLE NEURAL CORRELATE OF LIMITED CAPACITY

    COMPETITION CAN BE BIASED BY NONSPATIAL FEEDBACK

    FILTERING OF UNWANTED INFORMATION IN HUMANS

    CONCLUSIONS

    Chapter 49: Learning and Memory: Basic Mechanisms

    PARADIGMS HAVE BEEN DEVELOPED TO STUDY ASSOCIATIVE AND NONASSOCIATIVE LEARNING

    INVERTEBRATE STUDIES: KEY INSIGHTS FROM APLYSIA INTO BASIC MECHANISMS OF LEARNING

    VERTEBRATE STUDIES: LONG-TERM POTENTIATION

    LONG-TERM DEPRESSION

    HOW DOES A CHANGE IN SYNAPTIC STRENGTH STORE A COMPLEX MEMORY?

    Chapter 50: Learning and Memory: Brain Systems

    INTRODUCTION

    HISTORY OF MEMORY SYSTEMS

    MAJOR MEMORY SYSTEMS OF THE MAMMALIAN BRAIN

    BEHAVIOR SUPPORTED BY MULTIPLE MEMORY SYSTEMS

    CONCLUSION

    Chapter 51: Language and Communication

    ANIMAL COMMUNICATION

    HUMAN LANGUAGE

    CONCLUSIONS

    Chapter 52: The Prefrontal Cortex and Executive Brain Functions

    INTRODUCTION

    CONTROLLED PROCESSING

    ANATOMY AND ORGANIZATION OF THE PREFRONTAL CORTEX

    EFFECTS OF DAMAGE TO THE PREFRONTAL CORTEX IN HUMANS

    NEUROIMAGING STUDIES AND PFC

    EFFECTS OF DAMAGE TO THE PREFRONTAL CORTEX IN MONKEYS

    NEUROPHYSIOLOGY OF THE PREFRONTAL CORTEX

    PFC Neurons Can Sustain Their Activity

    PFC Neural Activity Reflects Task Rules

    PFC Neurons Are Flexible

    PFC Neurons Encode Rewards

    THEORIES OF PREFRONTAL CORTEX FUNCTION

    Chapter 53: Consciousness

    Index

Product details

  • No. of pages: 1
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: February 11, 2008
  • Imprint: Academic Press
  • eBook ISBN: 9780080561028

About the Editors

Larry Squire

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd E. Bloom

Affiliations and Expertise

Scripps Research Institute, La Jolla, CA, USA

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Nicholas C. Spitzer

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Larry R. Squire

Larry R. Squire is Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego. He is also a Research Career Scientist at the Veterans Affairs Medical Center in San Diego. Squire is a member of the National Academy of Sciences and a past president of the Society for Neuroscience.

Affiliations and Expertise

VA Medical Center and University of California, La Jolla, California, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd Bloom

Floyd Bloom was the editor of Science magazine, now Brain Research.

Affiliations and Expertise

Scripps Clinic & Research Institute, La Jolla, CA, U.S.A.

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Nicholas Spitzer

Affiliations and Expertise

University of California, La Jolla, California, U.S.A.

Ratings and Reviews

Write a review

There are currently no reviews for "Fundamental Neuroscience"