Fundamental Neuroscience

Fundamental Neuroscience

3rd Edition - February 11, 2008

Write a review

  • Editors: Larry Squire, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh, Nicholas C. Spitzer, Larry R. Squire, Darwin Berg, Floyd Bloom, Sascha du Lac, Anirvan Ghosh, Nicholas Spitzer
  • eBook ISBN: 9780080561028

Purchase options

Purchase options
DRM-free (PDF, Mobi, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers!

Key Features

  • 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness
  • Additional text boxes describing key experiments, disorders, methods, and concepts
  • Multiple model system coverage beyond rats, mice, and monkeys
  • Extensively expanded index for easier referencing

Readership

Graduate students in neuroscience, neuroanatomy and neurophysiology, and neurobiology, researchers in neuroscience primarily, but also in the related fields of psychology, cell biology, molecular biology, genetics and any other areas of science with cross over into neuroscience research

Table of Contents

  • Preface to the Third Edition
    About The Editors
    Contributors

    I: NEUROSCIENCE
    1: Fundamentals of Neuroscience
    A BRIEF HISTORY OF NEUROSCIENCE
    THE TERMINOLOGY OF NERVOUS SYSTEMS IS HIERARCHICAL, DISTRIBUTED, DESCRIPTIVE, AND HISTORICALLY BASED
    NEURONS AND GLIA ARE CELLULAR BUILDING BLOCKS OF THE NERVOUS SYSTEM
    THE OPERATIVE PROCESSES OF NERVOUS SYSTEMS ARE ALSO HIERARCHICAL
    CELLULAR ORGANIZATION OF THE BRAIN
    ORGANIZATION OF THIS TEXT
    THIS BOOK IS INTENDED FOR A BROAD RANGE OF SCHOLARS OF THE NEUROSCIENCES
    CLINICAL ISSUES IN THE NEUROSCIENCES
    THE SPIRIT OF EXPLORATION CONTINUES
    THE GENOMIC INVENTORY IS A GIANT STEP FORWARD
    NEUROSCIENCE TODAY: A COMMUNAL ENDEAVOR
    THE CREATION OF KNOWLEDGE
    RESPONSIBLE CONDUCT
    SUMMARY

    2: Basic Plan of the Nervous System
    INTRODUCTION
    EVOLUTION HIGHLIGHTS: GENERAL ORGANIZING PRINCIPLES
    DEVELOPMENT REVEALS BASIC VERTEBRATE PARTS
    THE BASIC PLAN OF NERVOUS SYSTEM CONNECTIVITY
    OVERVIEW OF THE ADULT MAMMALIAN NERVOUS SYSTEM

    II: CELLULAR AND MOLECULAR NEUROSCIENCE
    3: Cellular Components of Nervous Tissue
    NEURONS
    SPECIFIC EXAMPLES OF DIFFERENT NEURONAL TYPES
    NEUROGLIA
    CEREBRAL VASCULATURE

    4: Subcellular Organization of the Nervous System: Organelles and Their Functions
    AXONS AND DENDRITES: UNIQUE STRUCTURAL COMPONENTS OF NEURONS
    PROTEIN SYNTHESIS IN NERVOUS TISSUE
    CYTOSKELETONS OF NEURONS AND GLIAL CELLS
    MOLECULAR MOTORS IN THE NERVOUS SYSTEM
    BUILDING AND MAINTAINING NERVOUS SYSTEM CELLS

    5: Electrotonic Properties of Axons and Dendrites
    TOWARD A THEORY OF NEURONAL INFORMATION PROCESSING
    BASIC TOOLS: CABLE THEORY AND COMPARTMENTAL MODELS
    SPREAD OF STEADY-STATE SIGNALS
    SPREAD OF TRANSIENT SIGNALS
    ELECTROTONIC PROPERTIES UNDERLYING PROPAGATION IN AXONS
    ELECTROTONIC SPREAD IN DENDRITES
    DYNAMIC PROPERTIES OF PASSIVE ELECTROTONIC STRUCTURE
    RELATING PASSIVE TO ACTIVE POTENTIALS

    6: Membrane Potential and Action Potential
    MEMBRANE POTENTIAL
    ACTION POTENTIAL

    7: Neurotransmitters
    SEVERAL MODES OF NEURONAL COMMUNICATION EXIST
    CHEMICAL TRANSMISSION
    CLASSICAL NEUROTRANSMITTERS
    NONCLASSICAL NEUROTRANSMITTERS
    PEPTIDE TRANSMITTERS
    UNCONVENTIONAL TRANSMITTERS
    SYNAPTIC TRANSMISSION IN PERSPECTIVE

    8: Release of Neurotransmitters
    TRANSMITTER RELEASE IS QUANTAL
    EXCITATION–SECRETION COUPLING
    MOLECULAR MECHANISMS OF THE NERVE TERMINAL
    QUANTAL ANALYSIS: PROBING SYNAPTIC PHYSIOLOGY
    SHORT-TERM SYNAPTIC PLASTICITY

    9: Neurotransmitter Receptors
    IONOTROPIC RECEPTORS
    G-PROTEIN COUPLED RECEPTORS

    10: Intracellular Signaling
    SIGNALING THROUGH G-PROTEIN-LINKED RECEPTORS
    MODULATION OF NEURONAL FUNCTION BY PROTEIN KINASES AND PHOSPHATASES
    INTRACELLULAR SIGNALING AFFECTS NUCLEAR GENE EXPRESSION

    11: Postsynaptic Potentials and Synaptic Integration
    IONOTROPIC RECEPTORS: MEDIATORS OF FAST EXCITATORY AND INHIBITORY SYNAPTIC POTENTIALS
    METABOTROPIC RECEPTORS: MEDIATORS OF SLOW SYNAPTIC POTENTIALS
    INTEGRATION OF SYNAPTIC POTENTIALS

    12: Complex Information Processing in Dendrites
    STRATEGIES FOR STUDYING COMPLEX DENDRITES
    BUILDING PRINCIPLES STEP BY STEP
    AN AXON PLACES CONSTRAINTS ON DENDRITIC PROCESSING
    DENDRODENDRITIC INTERACTIONS BETWEEN AXONAL CELLS
    PASSIVE DENDRITIC TREES CAN PERFORM COMPLEX COMPUTATIONS
    SEPARATION OF DENDRITIC FIELDS ENHANCES COMPLEX INFORMATION PROCESSING
    DISTAL DENDRITES CAN BE CLOSELY LINKED TO AXONAL OUTPUT
    DEPOLARIZING AND HYPERPOLARIZING DENDRITIC CONDUCTANCES INTERACT DYNAMICALLY
    THE AXON HILLOCK-INITIAL SEGMENT ENCODES GLOBAL OUTPUT
    MULTIPLE IMPULSE INITIATION SITES ARE UNDER DYNAMIC CONTROL
    RETROGRADE IMPULSE SPREAD INTO DENDRITES CAN HAVE MANY FUNCTIONS
    EXAMPLES OF HOW VOLTAGE-GATED CHANNELS ENHANCE DENDRITIC INFORMATION PROCESSING
    DENDRITIC SPINES ARE MULTIFUNCTIONAL MICROINTEGRATIVE UNITS
    SUMMARY: THE DENDRITIC TREE AS A COMPLEX INFORMATION PROCESSING SYSTEM

    13: Brain Energy Metabolism
    ENERGY METABOLISM OF THE BRAIN AS A WHOLE ORGAN
    TIGHT COUPLING OF NEURONAL ACTIVITY, BLOOD FLOW, AND ENERGY METABOLISM
    ENERGY-PRODUCING AND ENERGY-CONSUMING PROCESSES IN THE BRAIN
    BRAIN ENERGY METABOLISM AT THE CELLULAR LEVEL
    GLUTAMATE AND NITROGEN METABOLISM: A COORDINATED SHUTTLE BETWEEN ASTROCYTES AND NEURONS
    THE ASTROCYTE-NEURON METABOLIC UNIT

    III: NERVOUS SYSTEM DEVELOPMENT
    14: Neural Induction and Pattern Formation
    NEURAL INDUCTION
    EARLY NEURAL PATTERNING
    REGIONALIZATION OF THE CENTRAL NERVOUS SYSTEM
    CONCLUSIONS

    15: Cellular Determination
    ORIGINS AND GENERATION OF NEURONAL PROGENITORS
    SPATIAL AND TEMPORAL COORDINATES OF NEURONAL SPECIFICATION
    THE PRONEURAL AND NEUROGENIC GENES
    ASYMMETRIC CELL DIVISION AND CELL FATE
    CENTRAL NEURONS AND GLIA
    SENSORY NEURONS OF THE PERIPHERAL NERVOUS SYSTEM
    THE RETINA: A COLLABORATION OF INTRINSIC AND EXTRINSIC CUES
    COMBINATORIAL CODING IN MOTOR NEURONS DETERMINATION
    CELLS OF THE CEREBRAL CORTEX
    CONCLUSIONS

    16: Neurogenesis and Migration
    INTRODUCTION
    DEVELOPMENT OF THE PERIPHERAL NERVOUS SYSTEM
    CELL MIGRATION IN THE CNS

    17: Growth Cones and Axon Pathfinding
    GROWTH CONES ARE ACTIVELY GUIDED
    GUIDANCE CUES FOR DEVELOPING AXONS
    GUIDANCE CUES AND THE CONTROL OF CYTOSKELETAL DYNAMICS
    GUIDANCE AT THE MIDLINE: CHANGING RESPONSES TO MULTIPLE CUES

    18: Target Selection, Topographic Maps, and Synapse Formation
    TARGET SELECTION
    DEVELOPMENT OF THE NEUROMUSCULAR SYNAPSE
    SYNAPSE FORMATION IN THE CENTRAL NERVOUS SYSTEM

    19: Programmed Cell Death and Neurotrophic Factors
    CELL DEATH AND THE NEUROTROPHIC HYPOTHESIS
    THE ORIGINS OF PROGRAMMED CELL DEATH AND ITS WIDESPREAD OCCURRENCE IN THE DEVELOPING NERVOUS SYSTEM
    FUNCTIONS OF NEURONAL PROGRAMMED CELL DEATH
    MODES OF CELL DEATH IN DEVELOPING NEURONS
    THE MODE OF NEURONAL CELL DEATH REFLECTS THE ACTIVATION OF DISTINCT BIOCHEMICAL AND MOLECULAR MECHANISMS
    NERVE GROWTH FACTOR: THE PROTOTYPE TARGET-DERIVED NEURONAL SURVIVAL FACTOR
    THE NEUROTROPHIN FAMILY
    NEUROTROPHIN RECEPTORS
    SECRETION AND AXONAL TRANSPORT OF NEUROTROPHINS AND PRO-NEUROTROPHINS
    SIGNAL TRANSDUCTION THROUGH TRK RECEPTORS
    CYTOKINES AND GROWTH FACTORS HAVE MULTIPLE ACTIVITIES
    PROGRAMMED CELL DEATH IS REGULATED BY INTERACTIONS WITH TARGETS, AFFERENTS, AND NONNEURONAL CELLS
    THE ROLE OF PROGRAMMED CELL DEATH IN NEUROPATHOLOGY

    20: Synapse Elimination
    OVERVIEW
    THE PURPOSE OF SYNAPSE ELIMINATION
    A STRUCTURAL ANALYSIS OF SYNAPSE ELIMINATION AT THE NEUROMUSCULAR JUNCTION
    A ROLE FOR INTERAXONAL COMPETITION AND ACTIVITY
    IS SYNAPSE ELIMINATION STRICTLY A DEVELOPMENTAL PHENOMENON?
    SUMMARY

    21: Dendritic Development
    DYNAMICS OF DENDRITIC ARBOR DEVELOPMENT
    GENETIC CONTROL OF DENDRITE DEVELOPMENT IN DROSOPHILA
    EXTRACELLULAR REGULATION OF DENDRITIC DEVELOPMENT IN THE MAMMALIAN BRAIN
    EFFECT OF EXPERIENCE ON DENDRITIC DEVELOPMENT
    MECHANISMS THAT MEDIATE ACTIVITY-DEPENDENT DENDRITIC GROWTH
    CONVERGENCE AND DIVERGENCE
    CONCLUSION

    22: Early Experience and Sensitive Periods
    BIRDSONG: LEARNED BY EXPERIENCE
    SOUND LOCALIZATION: CALIBRATED BY EARLY EXPERIENCE IN THE OWL
    PRINCIPLES OF DEVELOPMENTAL LEARNING
    IV: SENSORY SYSTEMS

    23: Fundamentals of Sensory Systems
    SENSATION AND PERCEPTION
    RECEPTORS
    PERIPHERAL ORGANIZATION AND PROCESSING
    CENTRAL PATHWAYS AND PROCESSING
    SENSORY CORTEX
    SUMMARY

    24: Chemical Senses: Taste and Olfaction
    TASTE
    OLFACTION
    PHEROMONE DETECTION

    25: Somatosensory System
    PERIPHERAL MECHANISMS OF SOMATIC SENSATION
    NOCICEPTION, THERMORECEPTION, AND ITCH
    CNS COMPONENTS OF SOMATIC SENSATION
    THALAMIC MECHANISMS OF SOMATIC SENSATION
    THE PATH FROM NOCICEPTION TO PAIN
    THE TRIGEMINAL SYSTEM (Fig. 25.16)
    CORTICAL REPRESENTATION OF TOUCH

    26: Audition
    EXTERNAL AND MIDDLE EAR
    THE COCHLEA
    THE AUDITORY NERVE
    CENTRAL NERVOUS SYSTEM

    27: Vision
    OVERVIEW
    THE EYE AND THE RETINA
    P and M Pathways Have Different Response Properties
    M Cells Are Highly Sensitive to Contrast
    THE RETINOGENICULOCORTICAL PATHWAY

    V: MOTOR SYSTEMS
    28: Fundamentals of Motor Systems
    BASIC COMPONENTS OF THE MOTOR SYSTEM
    MOTOR PROGRAMS COORDINATE BASIC MOTOR PATTERNS
    ROLES OF DIFFERENT PARTS OF THE NERVOUS SYSTEM IN THE CONTROL OF MOVEMENT
    CONCLUSION

    29: The Spinal and Peripheral Motor System
    LOCOMOTION IS A CYCLE
    CONNECTING THE SPINAL CORD TO THE PERIPHERY
    SPINAL INTERNEURON NETWORKS
    DESCENDING CONTROL OF SPINAL CIRCUITS
    SENSORY MODULATION

    30: Descending Control of Movement
    THE MEDIAL POSTURAL SYSTEM
    THE LATERAL VOLUNTARY SYSTEM
    SUMMARY

    31: The Basal Ganglia
    BASAL GANGLIA ANATOMY
    GPi Is the Primary Basal Ganglia Output for Limb Movements
    SIGNALING IN BASAL GANGLIA
    THE EFFECT OF BASAL GANGLIA DAMAGE ON MOVEMENT
    FUNDAMENTAL PRINCIPLES OF BASAL GANGLIA OPERATION FOR MOTOR CONTROL
    BASAL GANGLIA PARTICIPATION IN NONMOTOR FUNCTIONS

    32: Cerebellum
    ANATOMY AND PHYLOGENETIC DEVELOPMENT OF THE CEREBELLUM
    ASSESSING CEREBELLAR FUNCTION
    A Cerebellar Role in Rehabilitation? Functional Recovery through Relearning after Damage of Other Parts of the Nervous System

    33: Eye Movements
    EYE MOVEMENTS ARE USED TO STABILIZE GAZE OR TO SHIFT GAZE
    THE MECHANICS OF MOVING THE EYES
    THE FUNDAMENTAL CIRCUITS FOR STABILIZING GAZE
    THE COMMANDS FOR SHIFTING GAZE ARE FORMED IN THE BRAIN STEM
    GAZE SHIFTS ARE CONTROLLED BY THE MIDBRAIN AND FOREBRAIN
    THE CONTROL OF GAZE SHIFTS INVOLVES HIGHER-ORDER PROCESSES
    THE CONTROL OF EYE MOVEMENTS CHANGES OVER TIME
    CONCLUSIONS

    VI: REGULATORY SYSTEMS
    34: The Hypothalamus: An Overview of Regulatory Systems
    HISTORICAL PERSPECTIVE
    HYPOTHALAMIC CYTOARCHITECTURE
    FUNCTIONAL ORGANIZATION OF THE HYPOTHALAMUS
    EFFECTOR SYSTEMS OF THE HYPOTHALAMUS ARE HORMONAL AND SYNAPTIC

    35: Central Control of Autonomic Functions: Organization of the Autonomic Nervous System
    SYMPATHETIC DIVISION: ORGANIZED TO MOBILIZE THE BODY FOR ACTIVITY
    PARASYMPATHETIC DIVISION: ORGANIZED FOR ENERGY CONSERVATION
    THE ENTERIC DIVISION OF THE ANS: THE NERVE NET FOUND IN THE WALLS OF VISCERAL ORGANS
    ANS PHARMACOLOGY: TRANSMITTER AND RECEPTOR CODING
    AUTONOMIC COORDINATION OF HOMEOSTASIS
    HIERARCHICALLY ORGANIZED ANS CIRCUITS IN THE CNS
    PERSPECTIVE: FUTURE OF THE AUTONOMIC NERVOUS SYSTEM
    SUMMARY AND GENERAL CONCLUSIONS

    36: Neural Regulation of the Cardiovascular System
    AN ANATOMICAL FRAMEWORK
    A5 Cell Group
    A1 Cell Group
    ANATOMY AND CHEMICAL PROPERTIES OF AUTONOMIC PATHWAYS
    NETWORK GENERATORS
    SHORT-TERM CONTROL MECHANISMS
    REFLEX CONTROL OF THE CARDIOVASCULAR SYSTEM
    ARTERIAL BARORECEPTORS
    PERIPHERAL ARTERIAL CHEMORECEPTORS
    CARDIAC RECEPTORS
    ABDOMINAL VISCERAL REFLEXES

    37: Neural Control of Breathing
    EARLY NEUROSCIENCE AND THE BRAIN STEM
    CENTRAL NERVOUS SYSTEM AND BREATHING
    WHERE ARE THE NEURONS GENERATING RESPIRATORY PATTERN?
    DISCHARGE PATTERNS OF RESPIRATORY NEURONS
    WHERE ARE THE NEURONS THAT GENERATE THE BREATHING RHYTHM?
    SENSORY INPUTS AND ALTERED BREATHING
    MECHANORECEPTORS IN THE LUNGS ADJUST BREATHING PATTERN AND INITIATE PROTECTIVE REFLEXES
    MODULATION AND PLASTICITY OF RESPIRATORY MOTOR OUTPUT
    SUPRAPONTINE STRUCTURES AND BREATHING

    38: Food Intake and Metabolism
    CALORIC HOMEOSTASIS
    ROLE OF CALORIC HOMEOSTASIS IN CONTROL OF FOOD INTAKE
    CENTRAL CONTROL OF FOOD INTAKE
    NEUROPEPTIDES AND THE CONTROL OF FOOD INTAKE

    39: Water Intake and Body Fluids
    BODY FLUID PHYSIOLOGY
    OSMOTIC HOMEOSTASIS
    VOLUME HOMEOSTASIS

    40: Neuroendocrine Systems
    THE HYPOTHALAMUS IS A NEUROENDOCRINE ORGAN
    HYPOTHALAMIC RELEASING/INHIBITING HORMONES AND THEIR TARGETS
    THE HYPOTHALAMIC–ADENOHYPOPHYSIAL NEUROENDOCRINE SYSTEMS
    THE HYPOTHALAMIC-NEUROHYPOPHYSIAL SYSTEMS
    HORMONES AND THE BRAIN

    41: Circadian Timekeeping
    OVERVIEW OF THE MAMMALIAN CIRCADIAN TIMING SYSTEM
    THE SUPRACHIASMATIC NUCLEI ARE THE SITE OF THE PRIMARY CIRCADIAN PACEMAKER IN MAMMALS
    A HIERARCHY OF CELL-AUTONOMOUS CIRCADIAN OSCILLATORS
    THE MOLECULAR BASIS FOR CIRCADIAN OSCILLATION IS A TRANSCRIPTIONAL FEEDBACK LOOP
    CIRCADIAN PHOTORECEPTION
    CIRCADIAN OUTPUT MECHANISMS
    DIVERSITY OF OUTPUT PATHWAYS LEADING TO PHYSIOLOGICAL RHYTHMS
    GENERAL SUMMARY

    42: Sleep, Dreaming, and Wakefulness
    THE TWO STATES OF SLEEP: RAPID EYE MOVEMENT AND NONRAPID EYE MOVEMENT
    SLEEP IN THE MODERN ERA OF NEUROSCIENCE
    ANATOMY AND PHYSIOLOGY OF BRAIN STEM REGULATORY SYSTEMS
    MODELING THE CONTROL OF BEHAVIORAL STATE
    SLEEP HAS MULTIPLE FUNCTIONS

    43: Reward, Motivation, and Addiction
    REWARD AND MOTIVATION
    ADDICTION

    VII: BEHAVIORAL AND COGNITIVE NEUROSCIENCE
    44: Human Brain Evolution
    EVOLUTIONARY AND COMPARATIVE PRINCIPLES
    EVOLUTION OF PRIMATE BRAINS
    WHY BRAIN SIZE IS IMPORTANT
    CONCLUSIONS

    45: Cognitive Development and Aging
    BRAIN DEVELOPMENT
    COGNITIVE DEVELOPMENT AND AGING: A LIFE SPAN PERSPECTIVE
    PATHOLOGICAL PROCESSES IN COGNITIVE DEVELOPMENT AND AGING

    46: Visual Perception of Objects
    THE PROBLEM OF OBJECT RECOGNITION
    SUBSTRATES FOR OBJECT PERCEPTION AND RECOGNITION: EARLY EVIDENCE FROM BRAIN DAMAGE
    VISUAL PATHWAYS FOR OBJECT PROCESSING IN NONHUMAN PRIMATES
    NEURONAL PROPERTIES WITHIN THE OBJECT RECOGNITION PATHWAY
    FUNCTIONAL NEUROIMAGING AND ELECTROPHYSIOLOGY OF OBJECT RECOGNITION IN HUMANS
    PERCEPTION AND RECOGNITION OF SPECIFIC CLASSES OF OBJECTS
    OVERALL SUMMARY

    47: Spatial Cognition
    NEURAL SYSTEMS FOR SPATIAL COGNITION
    PARIETAL CORTEX
    FRONTAL CORTEX
    HIPPOCAMPUS AND ADJACENT CORTEX
    SPATIAL COGNITION AND SPATIAL ACTION

    48: Attention
    INTRODUCTION
    VARIETIES OF ATTENTION
    NEGLECT SYNDROME: A DEFICIT OF SPATIAL ATTENTION
    SINGLE UNIT RECORDING STUDIES IN NONHUMAN PRIMATES PROVIDE CONVERGENT EVIDENCE FOR A FRONTO-PARIETAL ATTENTIONAL CONTROL SYSTEM
    ATTENTION AFFECTS NEURAL ACTIVITY IN THE HUMAN VISUAL CORTEX IN THE PRESENCE AND ABSENCE OF VISUAL STIMULATION
    ATTENTION INCREASES SENSITIVITY AND BOOSTS THE CLARITY OF SIGNALS GENERATED BY NEURONS IN PARTS OF THE VISUAL SYSTEM DEVOTED TO PROCESSING INFORMATION ABOUT OBJECTS
    ATTENTION MODULATES NEURAL RESPONSES IN THE HUMAN LATERAL GENICULATE NUCLEUS
    THE VISUAL SEARCH PARADIGM HAS BEEN USED TO STUDY THE ROLE OF ATTENTION IN SELECTING RELEVANT STIMULI FROM WITHIN A CLUTTERED VISUAL ENVIRONMENT
    WHERE IS THE COMPUTATIONAL BOTTLENECK AS REVEALED BY SEARCH TASKS?
    NEURONAL RECEPTIVE FIELDS ARE A POSSIBLE NEURAL CORRELATE OF LIMITED CAPACITY
    COMPETITION CAN BE BIASED BY NONSPATIAL FEEDBACK
    FILTERING OF UNWANTED INFORMATION IN HUMANS
    CONCLUSIONS

    49: Learning and Memory: Basic Mechanisms
    PARADIGMS HAVE BEEN DEVELOPED TO STUDY ASSOCIATIVE AND NONASSOCIATIVE LEARNING
    INVERTEBRATE STUDIES: KEY INSIGHTS FROM APLYSIA INTO BASIC MECHANISMS OF LEARNING
    VERTEBRATE STUDIES: LONG-TERM POTENTIATION
    LONG-TERM DEPRESSION
    HOW DOES A CHANGE IN SYNAPTIC STRENGTH STORE A COMPLEX MEMORY?

    50: Learning and Memory: Brain Systems
    INTRODUCTION
    HISTORY OF MEMORY SYSTEMS
    MAJOR MEMORY SYSTEMS OF THE MAMMALIAN BRAIN
    BEHAVIOR SUPPORTED BY MULTIPLE MEMORY SYSTEMS
    CONCLUSION

    51: Language and Communication
    ANIMAL COMMUNICATION
    HUMAN LANGUAGE
    CONCLUSIONS

    52: The Prefrontal Cortex and Executive Brain Functions
    INTRODUCTION
    CONTROLLED PROCESSING
    ANATOMY AND ORGANIZATION OF THE PREFRONTAL CORTEX
    EFFECTS OF DAMAGE TO THE PREFRONTAL CORTEX IN HUMANS
    NEUROIMAGING STUDIES AND PFC
    EFFECTS OF DAMAGE TO THE PREFRONTAL CORTEX IN MONKEYS
    NEUROPHYSIOLOGY OF THE PREFRONTAL CORTEX
    PFC Neurons Can Sustain Their Activity
    PFC Neural Activity Reflects Task Rules
    PFC Neurons Are Flexible
    PFC Neurons Encode Rewards
    THEORIES OF PREFRONTAL CORTEX FUNCTION
    53: Consciousness
    Index

Product details

  • No. of pages: 1
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: February 11, 2008
  • Imprint: Academic Press
  • eBook ISBN: 9780080561028

About the Editors

Larry Squire

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd E. Bloom

Affiliations and Expertise

Scripps Research Institute, La Jolla, CA, USA

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Nicholas C. Spitzer

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Larry R. Squire

Larry R. Squire is Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego. He is also a Research Career Scientist at the Veterans Affairs Medical Center in San Diego. Squire is a member of the National Academy of Sciences and a past president of the Society for Neuroscience.

Affiliations and Expertise

Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego; Research Career Scientist at the Veterans Affairs Medical Center in San Diego; member of the National Academy of Sciences and a past president of the Society for Neuroscience.

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd Bloom

Floyd Bloom was the editor of Science magazine, now Brain Research.

Affiliations and Expertise

Scripps Clinic & Research Institute, La Jolla, CA, U.S.A.

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Nicholas Spitzer

Affiliations and Expertise

University of California, La Jolla, California, U.S.A.

Ratings and Reviews

Write a review

There are currently no reviews for "Fundamental Neuroscience"