Fundamental Neuroscience

Fundamental Neuroscience

2nd Edition - November 13, 2002

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  • Editors: Larry Squire, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh, Larry R. Squire, Nicholas C. Spitzer, Floyd Bloom, Susan McConnell, James L. Roberts, Nicholas Spitzer, Michael Zigmond
  • eBook ISBN: 9780080521800

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Description

With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates.The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.

Key Features

Key Features
* Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters
* Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts
* Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM

Readership

Graduate students and researchers in neuroscience, as well as medical students.

Table of Contents

  • Neuroscience
    Cellular and Molecular Neuroscience
    Nervous System Development
    Sensory Systems
    Motor Systems
    Regulatory Systems
    Behavioral and Cognitive Neuroscience

Product details

  • No. of pages: 1426
  • Language: English
  • Copyright: © Academic Press 2002
  • Published: November 13, 2002
  • Imprint: Academic Press
  • eBook ISBN: 9780080521800

About the Editors

Larry Squire

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd E. Bloom

Affiliations and Expertise

Scripps Research Institute, La Jolla, CA, USA

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Larry R. Squire

Larry R. Squire is Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego. He is also a Research Career Scientist at the Veterans Affairs Medical Center in San Diego. Squire is a member of the National Academy of Sciences and a past president of the Society for Neuroscience.

Affiliations and Expertise

Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego; Research Career Scientist at the Veterans Affairs Medical Center in San Diego; member of the National Academy of Sciences and a past president of the Society for Neuroscience.

Nicholas C. Spitzer

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd Bloom

Floyd Bloom was the editor of Science magazine, now Brain Research.

Affiliations and Expertise

Scripps Clinic & Research Institute, La Jolla, CA, U.S.A.

Susan McConnell

Affiliations and Expertise

Stanford University, Palo Alto, California, U.S.A.

James L. Roberts

Affiliations and Expertise

Trinity University, San Antonio, TX, USA

Nicholas Spitzer

Affiliations and Expertise

University of California, La Jolla, California, U.S.A.

Michael Zigmond

Affiliation: Professor of Neurology, Department of Neurology, University of Pittsburg, USA

Over the past year, Dr. Zigmond and his research team have continued their studies of cellular and animal models to examine Parkinson's disease (PD), which they believe is a multi-factorial disorder. A major focus of the lab is the role of intracellular signaling cascades in determining the viability of dopamine (DA) neurons. They hypothesize, for example, that trophic factors such as GDNF and oxidative stress can both stimulate intracellular survival cascades, including those involving MAP kinases. They further believe that endogenous trophic factor expression can be enhanced by exercise which in turn can be neuroprotective. And they have evidence that protection also can derive from acute exposure to low levels of a neurotoxin, a form of preconditioning. Last year their work included studies of the impact of oxidative stress induced by 6-hydroxydopamine (6-OHDA), a DA analogue that is concentrated in DA cells and rapidly breaks down to form reactive oxygen species. Results from these and other studies suggest that DA neurons react to stress by initiating a set of protective responses. Learning more about these responses may provide insights into new treatment modalities for PD.

In the coming year, Dr. Zigmond will continue to focus on understanding the strategies DA neurons use to reduce their vulnerability to intracellular stress. For example, studies are underway to determine if inhibition of trophic actor action or of kinase activation will block neuroprotection seen with exercise or GDNF or increase 6-OHDA toxicity. Some of these studies involve the preparation of molecular biological tools that maintain kinases in a constitutively or dominant negative state and/or localize a kinase to the cytoplasm or the nucleus. In addition, histochemical methods are being developed to quantify kinase levels in different cellular compartments of identified cells.

Affiliations and Expertise

Professor of Neurology, Department of Neurology, University of Pittsburgh, Pennsylvania, U.S.A.

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