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Fundamental Neuroscience - 2nd Edition - ISBN: 9780080521800

Fundamental Neuroscience

2nd Edition

Editors: Larry Squire Darwin Berg Floyd E. Bloom Sascha du Lac Anirvan Ghosh Larry R. Squire Nicholas C. Spitzer Floyd Bloom Susan McConnell James L. Roberts Nicholas Spitzer Michael Zigmond
eBook ISBN: 9780080521800
Imprint: Academic Press
Published Date: 13th November 2002
Page Count: 1426
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With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates.

The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.

Key Features

Key Features
* Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters
* Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts
* Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM


Graduate students and researchers in neuroscience, as well as medical students.

Table of Contents

Cellular and Molecular Neuroscience
Nervous System Development
Sensory Systems
Motor Systems
Regulatory Systems
Behavioral and Cognitive Neuroscience


No. of pages:
© Academic Press 2002
13th November 2002
Academic Press
eBook ISBN:

About the Editors

Larry Squire

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd E. Bloom

Affiliations and Expertise

Scripps Research Institute, La Jolla, CA, USA

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Larry R. Squire

Larry R. Squire is Distinguished Professor of Psychiatry, Neurosciences, and Psychology at the University of California, San Diego. He is also a Research Career Scientist at the Veterans Affairs Medical Center in San Diego. Squire is a member of the National Academy of Sciences and a past president of the Society for Neuroscience.

Affiliations and Expertise

VA Medical Center and University of California, La Jolla, California, USA

Nicholas C. Spitzer

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd Bloom

Floyd Bloom was the editor of Science magazine, now Brain Research.

Affiliations and Expertise

Scripps Clinic & Research Institute, La Jolla, CA, U.S.A.

Susan McConnell

Affiliations and Expertise

Stanford University, Palo Alto, California, U.S.A.

James L. Roberts

Affiliations and Expertise

Trinity University, San Antonio, TX, USA

Nicholas Spitzer

Affiliations and Expertise

University of California, La Jolla, California, U.S.A.

Michael Zigmond

Affiliation: Professor of Neurology, Department of Neurology, University of Pittsburg, USA

Over the past year, Dr. Zigmond and his research team have continued their studies of cellular and animal models to examine Parkinson's disease (PD), which they believe is a multi-factorial disorder. A major focus of the lab is the role of intracellular signaling cascades in determining the viability of dopamine (DA) neurons. They hypothesize, for example, that trophic factors such as GDNF and oxidative stress can both stimulate intracellular survival cascades, including those involving MAP kinases. They further believe that endogenous trophic factor expression can be enhanced by exercise which in turn can be neuroprotective. And they have evidence that protection also can derive from acute exposure to low levels of a neurotoxin, a form of preconditioning. Last year their work included studies of the impact of oxidative stress induced by 6-hydroxydopamine (6-OHDA), a DA analogue that is concentrated in DA cells and rapidly breaks down to form reactive oxygen species. Results from these and other studies suggest that DA neurons react to stress by initiating a set of protective responses. Learning more about these responses may provide insights into new treatment modalities for PD.

In the coming year, Dr. Zigmond will continue to focus on understanding the strategies DA neurons use to reduce their vulnerability to intracellular stress. For example, studies are underway to determine if inhibition of trophic actor action or of kinase activation will block neuroprotection seen with exercise or GDNF or increase 6-OHDA toxicity. Some of these studies involve the preparation of molecular biological tools that maintain kinases in a constitutively or dominant negative state and/or localize a kinase to the cytoplasm or the nucleus. In addition, histochemical methods are being developed to quantify kinase levels in different cellular compartments of identified cells.

Affiliations and Expertise

University of Pittsburgh, Pennsylvania, U.S.A.


" outstanding, comprehensive reference for clinicians, students, and neuroscientists."
"...that this is the most comprehensive text in the field today...anyone looking for the definitive text in neuroscience need look no further. This one is it...highly recommended for graduate and advanced undergraduate students."-LIFE SCIENCE BOOK REVIEW(2003)
"Fundamental Neuroscience is a remarkable resource... an extraordinarily detailed and comprehensive textbook with superb illustrations. I suspect it will become a definitive source of information in the field of neuroscience. It is ideal both as a textbook for graduate students and as a reference for teachers and research scientists alike. I recommend it highly."
—R. Ranney Mize, Past President, Association of Neuroscience Departments and Programs (ANDP)
"...this remarkable textbook is laid out in seven sections, covering in turn cellular and molecular neuroscience, nervous system development, sensory systems, motor systems, regulation of the body by the brain, and finally, behavioral and cognitive aspects of higher brain function. The origin of the book is significant...remarkable collection of both color and black-and-white illustrations... a considerable achievement..."
"Neuroscience is a broad field built upon concerted activities of numerous heterogeneous disciplines, and continuous efforts of integration are imperative. Fundamental Neuroscience represents such efforts and helps readers to comprehend the whole scope of neuroscience, a field which is rapidly growing in many directions, including clinical research and application."
—Masao Ito, Riken Brain Science Institute
"The presentation of material is clear, well-focused, right up-to-date and magnificently illustrated with excellent figures, tables and wonderful molecular diagrams. It excels in providing a neuroscientific basis for clinical neurological diseases. I found it to be a superb text of interdisciplinary neuroscience." @source:—Roger N. Rosenberg, Zale Distinguished Chair and Professor of Neurology, University Of Texas, Southwestern Medical Center at Dallas

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