Functioning of Transmembrane Receptors in Signaling Mechanisms

Functioning of Transmembrane Receptors in Signaling Mechanisms

Cell Signaling Collection

1st Edition - April 5, 2011

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  • Editors: Ralph A. Bradshaw, Edward A. Dennis
  • Paperback ISBN: 9780123822116
  • eBook ISBN: 9780123822123

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A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.

Key Features

  • Articles written and edited by experts in the field
  • Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events
  • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease


Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

Table of Contents

  • 1. Cell Signaling: Yesterday, Today, and Tomorrow

    2. Structural and Energetic Basis of Molecular Recognition

    3. Free Energy Landscapes in Protein-Protein Interactions

    4. Molecular Sociology

    5. Antibody–Antigen Recognition and Conformational Changes

    6. Binding Energetics in Antigen–Antibody Interfaces

    7. Immunoglobulin–Fc Receptor Interactions

    8. Ig-Superfold and its Variable Uses in Molecular Recognition

    9. T Cell Receptor/pMHC Complexes

    10. Mechanistic Features of Cell Surface Adhesion Receptors

    11. The Immunological Synapse

    12. NK Receptors

    13. Carbohydrate Recognition and Signaling

    14. Rhinovirus–Receptor Interactions

    15. HIV-1 Receptor Interactions

    16. Influenza Virus Neuraminidase Inhibitors

    17. Structural Basis of Signaling Events Involving Fibrinogen and Fibrin

    18. Structural Basis of Integrin Signaling

    19. Structures of Heterotrimeric G Proteins and their Complexes

    20. G-Protein-Coupled Receptor Structures

    21. Toll-like Receptors – Structure and Signaling

    22. Variable Lymphocyte Receptors

    23. Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures

    24. Chemokines and Chemokine Receptors: Structure and Function

    25. The 2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation

    26. Protease-Activated Receptors

    27. Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors

    28. Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors

    29. Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Clustering

    30. An Overview of Ion Channel Structure

    31. Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated

    32. Ion Permeation: Mechanisms of Ion Selectivity and Block

    33. Nicotinic Acetylcholine Receptors

    34. Ion Channels Regulated by Direct Binding of Cyclic Nucleotides

    35. Overview of Cytokine Receptors

    36. Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation

    37. Erythropoietin Receptor as a Paradigm for Cytokine Signaling

    38. The Fibroblast Growth Factor (FGF) Signaling Complex

    39. Structure of IFN-g and its Receptors

    40. Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface

    41. The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes

    42. The Mechanism of VEGFR Activation by VEGF

    43 . Receptor–Ligand Recognition in the TGFb Superfamily as Suggested by Crystal Structures

    44. Insulin Receptor Complex and Signaling by Insulin

    45. Structure and Mechanism of the Insulin Receptor Tyrosine Kinase

    46. IL-21 Increased Potency Desig

    47. Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State?

    48. Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling

    49. Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction

    50. Assembly of Signaling Complexes for TNF Receptor Family Molecules

    51. Mechanisms of CD40 Signaling in the Immune System

    52. Role of Lipid Domains in EGF Receptor Signaling

    53. Lipid-Mediated Localization of Signaling Proteins

    54. Organization of Photoreceptor Signaling Complexes

    55. Transmembrane Receptor Oligomerization

Product details

  • No. of pages: 456
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: April 5, 2011
  • Imprint: Academic Press
  • Paperback ISBN: 9780123822116
  • eBook ISBN: 9780123822123

About the Editors

Ralph A. Bradshaw

Ralph A. Bradshaw
Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover.

Affiliations and Expertise

Department of Chemistry and Pharmaceutical Chemistry; and Mass Spectrometry Facility, University of California, San Francisco, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA, USA

Edward A. Dennis

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

Affiliations and Expertise

Department of Chemistry and Biochemistry and Department of Pharmacology in the School of Medicine at the University of California, San Diego

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