Functioning of Transmembrane Receptors in Signaling Mechanisms

1st Edition

Cell Signaling Collection


  • Ralph Bradshaw
  • Edward A. Dennis
  • Functioning of Transmembrane Receptors in Signaling Mechanisms

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    A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.

    Key Features

    • Articles written and edited by experts in the field
    • Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events
    • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease


    Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

    Table of Contents

    1. Cell Signaling: Yesterday, Today, and Tomorrow

    2. Structural and Energetic Basis of Molecular Recognition

    3. Free Energy Landscapes in Protein-Protein Interactions

    4. Molecular Sociology

    5. Antibody–Antigen Recognition and Conformational Changes

    6. Binding Energetics in Antigen–Antibody Interfaces

    7. Immunoglobulin–Fc Receptor Interactions

    8. Ig-Superfold and its Variable Uses in Molecular Recognition

    9. T Cell Receptor/pMHC Complexes

    10. Mechanistic Features of Cell Surface Adhesion Receptors

    11. The Immunological Synapse

    12. NK Receptors

    13. Carbohydrate Recognition and Signaling

    14. Rhinovirus–Receptor Interactions

    15. HIV-1 Receptor Interactions

    16. Influenza Virus Neuraminidase Inhibitors

    17. Structural Basis of Signaling Events Involving Fibrinogen and Fibrin

    18. Structural Basis of Integrin Signaling

    19. Structures of Heterotrimeric G Proteins and their Complexes

    20. G-Protein-Coupled Receptor Structures

    21. Toll-like Receptors – Structure and Signaling

    22. Variable Lymphocyte Receptors

    23. Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures

    24. Chemokines and Chemokine Receptors: Structure and Function

    25. The 2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation

    26. Protease-Activated Receptors

    27. Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors

    28. Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors

    29. Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Clustering

    30. An Overview of Ion Channel Structure

    31. Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated

    32. Ion Permeati


    No. of pages:
    © 2011
    Academic Press
    Print ISBN:
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    About the authors

    Ralph Bradshaw

    Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.

    Edward A. Dennis

    Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.


    "This volume reprints 53 articles originally published in </Handbook of cell signaling, 2nd ed./> by Elsevier in 2010. The researchers describe the structure and role of cell surface receptors in signaling activities with separate sections on tyrosine kinase, cytokine, G protein-coupled, TGFB, TNF, and immunoglobin receptors. The opening chapters review the chemical principles of protein binding, FRET detection techniques, protein tyrosine phosphatases, and the formation of oligomers. Color figures are provided."--Reference and Research Book News