Functioning of Transmembrane Receptors in Signaling Mechanisms

1st Edition

Cell Signaling Collection

Authors:

  • Ralph Bradshaw
  • Edward A. Dennis
  • Functioning of Transmembrane Receptors in Signaling Mechanisms

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    Description

    A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.

    Key Features

    • Articles written and edited by experts in the field
    • Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events
    • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

    Readership

    Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

    Details

    No. of pages:
    456
    Language:
    English
    Copyright:
    © 2011
    Published:
    Imprint:
    Academic Press
    Print ISBN:
    9780123822116
    Electronic ISBN:
    9780123822123

    About the authors

    Ralph Bradshaw

    Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.

    Affiliations and Expertise

    Department of Chemistry and Pharmaceutical Chemistry; and Mass Spectrometry Facility, University of California, San Francisco, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA

    Edward A. Dennis

    Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

    Affiliations and Expertise

    Department of Chemistry and Biochemistry and Department of Pharmacology in the School of Medicine at the University of California, San Diego

    Reviews

    "This volume reprints 53 articles originally published in </Handbook of cell signaling, 2nd ed./> by Elsevier in 2010. The researchers describe the structure and role of cell surface receptors in signaling activities with separate sections on tyrosine kinase, cytokine, G protein-coupled, TGFB, TNF, and immunoglobin receptors. The opening chapters review the chemical principles of protein binding, FRET detection techniques, protein tyrosine phosphatases, and the formation of oligomers. Color figures are provided."--Reference and Research Book News