Functioning of Transmembrane Receptors in Signaling Mechanisms - 1st Edition - ISBN: 9780123822116, 9780123822123

Functioning of Transmembrane Receptors in Signaling Mechanisms

1st Edition

Cell Signaling Collection

Print ISBN: 9780123822116
eBook ISBN: 9780123822123
Imprint: Academic Press
Published Date: 5th April 2011
Page Count: 456
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A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.

Key Features

  • Articles written and edited by experts in the field
  • Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events
  • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease


Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

Table of Contents

1. Cell Signaling: Yesterday, Today, and Tomorrow

2. Structural and Energetic Basis of Molecular Recognition

3. Free Energy Landscapes in Protein-Protein Interactions

4. Molecular Sociology

5. Antibody–Antigen Recognition and Conformational Changes

6. Binding Energetics in Antigen–Antibody Interfaces

7. Immunoglobulin–Fc Receptor Interactions

8. Ig-Superfold and its Variable Uses in Molecular Recognition

9. T Cell Receptor/pMHC Complexes

10. Mechanistic Features of Cell Surface Adhesion Receptors

11. The Immunological Synapse

12. NK Receptors

13. Carbohydrate Recognition and Signaling

14. Rhinovirus–Receptor Interactions

15. HIV-1 Receptor Interactions

16. Influenza Virus Neuraminidase Inhibitors

17. Structural Basis of Signaling Events Involving Fibrinogen and Fibrin

18. Structural Basis of Integrin Signaling

19. Structures of Heterotrimeric G Proteins and their Complexes

20. G-Protein-Coupled Receptor Structures

21. Toll-like Receptors – Structure and Signaling

22. Variable Lymphocyte Receptors

23. Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures

24. Chemokines and Chemokine Receptors: Structure and Function

25. The 2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation

26. Protease-Activated Receptors

27. Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors

28. Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors

29. Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Clustering

30. An Overview of Ion Channel Structure

31. Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated

32. Ion Permeati


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© Academic Press 2011
Academic Press
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"This volume reprints 53 articles originally published in </Handbook of cell signaling, 2nd ed./> by Elsevier in 2010. The researchers describe the structure and role of cell surface receptors in signaling activities with separate sections on tyrosine kinase, cytokine, G protein-coupled, TGFB, TNF, and immunoglobin receptors. The opening chapters review the chemical principles of protein binding, FRET detection techniques, protein tyrosine phosphatases, and the formation of oligomers. Color figures are provided."--Reference and Research Book News