Functional Neuromarkers for Psychiatry

Functional Neuromarkers for Psychiatry

Applications for Diagnosis and Treatment

1st Edition - May 3, 2016

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  • Author: Juri Kropotov
  • eBook ISBN: 9780124105201
  • Hardcover ISBN: 9780124105133

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Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results.

Key Features

  • Identifies specific brain activation patterns that are neuromarkers for psychiatric disorders
  • Includes neuromarkers as seen via fMRI, PET, qEEG, and ERPs
  • Addresses neuromarkers for ADHD, schizophrenia, and OCD in detail
  • Provides information on using neuromarkers for diagnosis and/or personalized treatment


Psychiatrists, neuroscientists, researchers in clinical psychology and neurology

Table of Contents

  • Introduction

    Part 1 - Methods of assessing neuromarkers
    Chapter 1.1 - Theory of measurement
    Chapter 1.2 - Psychometrics and neuropsychological assessment
    Chapter 1.3 - Functional MRI
    Chapter 1.4 - Positron emission tomography
    Chapter 1.5 - Spontaneous electroencephalogram
    Chapter 1.6 - Event-related potentials

    Part 2 - Neuromarkers of cortical self-regulation
    Chapter 2.1 - Infraslow electrical oscillations
    Chapter 2.2 - Alpha rhythms
    Chapter 2.3 - Beta and gamma rhythms
    Chapter 2.4 - Frontal midline theta rhythm

    Part 3 - Information flow within the brain
    Chapter 3.1 - Sensory systems and attention modulation
    Chapter 3.2 - Executive system and cognitive control
    Chapter 3.3 - Affective system, emotions and stress
    Chapter 3.4 - Memory systems

    Part 4 - Methods of neuro-modulation
    Chapter 4.1 - Pharmacological approach
    Chapter 4.2 - Neurofeedback
    Chapter 4.3 - Electroconvulsive therapy
    Chapter 4.4 - Transcranial Direct Current Stimulation
    Chapter 4.5 - Transcranial magnetic stimulation
    Chapter 4.6 - Deep Brain Stimulation

    Part 5 - Neuromarkers in psychiatry
    Chapter 5.1 - Attention deficit hyperactivity disorder
    Chapter 5.2 - Schizophrenia
    Chapter 5.3 - Obsessive-compulsive disorder

    Part 6 - Assessing functional neuromarkers
    Chapter 6.1 - Working hypothesis
    Chapter 6.2 - Technical implementation
    Chapter 6.3 - Testing working hypothesis: spontaneous EEG
    Chapter 6.4 - Testing working hypothesis: Event-Related Proposals
    Chapter 6.5 - Monitoring treatment effects

    Part 7 - The State of the Art: Overview

    Chapter 7.1 - Objective Measures of Human Brain Functioning

    Chapter 7.2 - Rhythms of the Healthy Brain

    Chapter 7.3 - Information Flow in the Health Brain

    Chapter 7.4 - Current Treatment Options in Psychiatry

    Chapter 7.5 - Functional Neuromarkers in Diseased Brain

    Chapter 7.6 - Implementation in Clinical Practice


Product details

  • No. of pages: 498
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: May 3, 2016
  • Imprint: Academic Press
  • eBook ISBN: 9780124105201
  • Hardcover ISBN: 9780124105133

About the Author

Juri Kropotov

Juri D. Kropotov is the former president of the European Chapter of ISNR and the developer of the Mitsar-201 and 202 EEG amplifiers. Author of over 200 scientific papers and 9 books, he has three doctorates in theoretical physics, philosophy, and neurophysiology. He received the USSR State Prize in 1985, and the Copernicus Prize by the Polish Neuropsychological Society in 2009. His 2009 book Quantitative EEG: Event-Related Potentials and Neurotherapy received the award for the year’s most significant publication in the field of neurofeedback from the Foundation for Neurofeedback and Applied Neuroscience.

Affiliations and Expertise

N. P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences, St. Petersburg, Russian Federation; Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; and Andrzej Frycz Modrzewski Krakow University, Krakow, Poland

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