Functional Neural Transplantation III, Volume 201

1st Edition

Primary and Stem Cell Therapies for Brain Repair, Part II

Serial Volume Editors: Stephen B. Dunnett Anders Bjorklund
Hardcover ISBN: 9780444595447
eBook ISBN: 9780444595454
Imprint: Elsevier
Published Date: 13th December 2012
Page Count: 408
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Table of Contents

Advisory Editors


Chapter 1. Introduction (Part II)


Chapter 2. Transplantation in the future

1 Constraints

2 Future directions

Chapter 3. Neural differentiation and support of neuroregeneration of non-neural adult stem cells


1 Introduction

2 Adult non-neural stem cells

3 Bone marrow cells/umbilical cord blood cells

4 Endothelial cells/endothelial progenitor cells

5 Mesenchymal stem/stromal cells

6 Adult stem cells with greater potency

7 Adult stem cell grafts for stroke

8 Conclusions


Chapter 4. Stem cell repair of striatal ischemia

1 Introduction

2 Transplantation of NSPCs in stroke

3 Endogenous neural stem cells in stroke

4 Conclusions


Chapter 5. In vivo imaging of cell transplants in experimental ischemia


1 Introduction

2 Cell tracking by MRI

3 Cell tracking by OI

4 Cell tracking by PET

5 Multimodal cell tracking approaches

6 Conclusions


Chapter 6. Bone marrow stem cells in experimental stroke

1 Introduction

2 The impact of MSC transplantation in experimental stroke models: structural and functional changes

3 Intravenous delivery of human MSCs in a nonhuman primate model of stroke as a prelude to Phase I human clinical study

4 Clinical studies in stroke patients utilizing intravenously applied hMSCs

5 Prospects


Further reading

Chapter 7. Advantages and challenges of alternative sources of adult-derived stem cells for brain repair in stroke

1 Introduction

2 Adult stem cells

3 Neural stem cells

4 Mesenchymal stromal cells

5 Extraembryonic tissue stem cells

6 Umbilical cord blood

7 Adipose ti


This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist


Neuroscientists, psychologists, neurologists


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© Elsevier 2012
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About the Serial Volume Editors

Stephen B. Dunnett Serial Volume Editor

Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington’s disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson’s disease.

Affiliations and Expertise

Cardiff University, Cardiff, UK

Anders Bjorklund Serial Volume Editor

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients

Affiliations and Expertise

Lund University, Lund, Sweden