Description

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Key Features

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

Series Page

Contributors

Chapter 1. Introduction (Part I)

References

Chapter 2. Transplantation in the future

1. Constraints

2. Future directions

Chapter 3. Ethical challenges for using human cells in clinical cell therapy

1. Introduction

2. Challenges, ethical, and others

3. Scientific challenges and ethics

4. Societal concerns: legal and economic issues

5. Meeting ethical challenges and three theses

6. Stages and stage-related challenges

7. Concluding remarks

References

Chapter 4. Banking stem cells for research and clinical applications

Abbreviations

1. Introduction

2. What are cell banks and why are they important?

3. Banking cells for clinical application

4. Testing and characterization of cell banks

5. The international landscape and cell standardization

6. Conclusions and future perspectives

References

Chapter 5. Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation

1. Introduction

2. Survival of DA neurons in VM grafts

3. Differentiation and composition of VM grafts

4. Connectivity of VM grafts

5. Closing remarks

References

Chapter 6. Electrophysiological investigations of synaptic connectivity between host and graft neurons

1. Introduction

2. The desired functional phenotype: Electrophysiological properties of A9 dopaminergic neurons

3. In vivo versus in vitro grafting schemes

4. Electrophysiological properties of stem cell-derived dopaminergic neurons

5. Maturation versus functional integration

6. Correlations between functional integration and behavioral recovery

7. Pitfalls of assessing functional integration in grafting experiments

8. Concluding remarks and future perspectives

Details

No. of pages:
448
Language:
English
Copyright:
© 2012
Published:
Imprint:
Elsevier
Print ISBN:
9780444595751
Electronic ISBN:
9780444595881