Functional Microbial Genomics - 1st Edition - ISBN: 9780125215336, 9780080925035

Functional Microbial Genomics, Volume 33

1st Edition

Series Volume Editors: Brendan Wren Nick Dorrell
Hardcover ISBN: 9780125215336
eBook ISBN: 9780080925035
Imprint: Academic Press
Published Date: 12th December 2002
Page Count: 428
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Institutional Access


Table of Contents

GENOME SEQUENCE ANALYSIS Annotation of genomes
From sequence to consequence: in silico hypothesis generation and testing
The atlas visualisation of genome-wide information

CONSTRUCTION OF DNA MICROARRAYS Microarray design for bacterial genomes Glass slides microarrays for bacterial genomes

COMPARAIVE NUCLEIC ACID ANALYSIS Representational display analysis of Cdna and genome comparisons Application of DNA microarrays for comparative and evolutionary genomics Gene expression during host-pathogen interactions: approaches to bacterial mRNA extraction and labelling for microarray analysis High throughput in vivo screens: signature-tagged mutagenesis Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantitation of DNA-tagged strains

PROTEOME ANALYSIS Advances in bacterial proteome analysis Discovery of protein-protein interaction using two-hybrid systems

SECTION V APPLICATIONS OF MICROBIAL GENOMICS Cloning the metagenome: Culture-independent access to the diversity and functions of the uncultivated microbial world Reverse vaccinology: from genome to vaccine Microbial genomics for antibiotic target discovery

CASE STUDIES - BACTERIA Helicobacter pylori functional genomics
Streptomyces coelicolor A3(2): from genome sequence to function Functional analysis of the Bacillus subtilis genome

SECTION VII CASE STUDIES - PARASITES Plasmodium falciparum DNA microarrays and interpretation of data Functional analysis of the Plasmodium falciparum genome using transfection Chromosome fragmentation as an approach to whole genome analysis in trypanosomes


Description

GENOME SEQUENCE ANALYSIS Annotation of genomes
From sequence to consequence: in silico hypothesis generation and testing
The atlas visualisation of genome-wide information

CONSTRUCTION OF DNA MICROARRAYS Microarray design for bacterial genomes Glass slides microarrays for bacterial genomes

COMPARAIVE NUCLEIC ACID ANALYSIS Representational display analysis of Cdna and genome comparisons Application of DNA microarrays for comparative and evolutionary genomics Gene expression during host-pathogen interactions: approaches to bacterial mRNA extraction and labelling for microarray analysis High throughput in vivo screens: signature-tagged mutagenesis Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantitation of DNA-tagged strains

PROTEOME ANALYSIS Advances in bacterial proteome analysis Discovery of protein-protein interaction using two-hybrid systems

SECTION V APPLICATIONS OF MICROBIAL GENOMICS Cloning the metagenome: Culture-independent access to the diversity and functions of the uncultivated microbial world Reverse vaccinology: from genome to vaccine Microbial genomics for antibiotic target discovery

CASE STUDIES - BACTERIA Helicobacter pylori functional genomics
Streptomyces coelicolor A3(2): from genome sequence to function Functional analysis of the Bacillus subtilis genome

SECTION VII CASE STUDIES - PARASITES Plasmodium falciparum DNA microarrays and interpretation of data Functional analysis of the Plasmodium falciparum genome using transfection Chromosome fragmentation as an approach to whole genome analysis in trypanosomes

Key Features

  • Bioinformatic approaches to genome sequence analysis
  • Details the design, construction and applications of DNA microarrays
  • Covers advances in bacterial proteome and metagenome analysis
  • Describes functional genomic approaches for novel antibiotic target and vaccine candidate discovery
  • Presents case studies where functional genomic analyses have revolutionized our understanding of model species

Readership

Micro and molecular biologists, geneticists, parasitologists, virologists, pharmacologists, biotechnologists


Details

No. of pages:
428
Language:
English
Copyright:
© Academic Press 2003
Published:
Imprint:
Academic Press
eBook ISBN:
9780080925035
Hardcover ISBN:
9780125215336

Reviews

Praise for the Series: "An invaluable resource for the detailed analysis of cellular gene function and genome architecture." —NATURE


About the Series Volume Editors

Brendan Wren Series Volume Editor

Affiliations and Expertise

London School of Hygiene & Tropical Medicine, U.K.

Nick Dorrell Series Volume Editor

Affiliations and Expertise

London School of Hygiene and Tropical Medicine, UK