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Frontiers in Catecholamine Research - 1st Edition - ISBN: 9780080179223, 9781483155869

Frontiers in Catecholamine Research

1st Edition

Proceedings of the Third International Catecholamine Symposium Held at the University of Strasbourg, Strasbourg, France May 20–25, 1973

Editors: Earl Usdin Solomon H. Snyder
eBook ISBN: 9781483155869
Imprint: Pergamon
Published Date: 1st January 1973
Page Count: 1236
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Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973. This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.

Table of Contents






I. Keynote Address

The Impact of Monoamine Research on Drug Development

II. Enzymes

Two Mechanisms of Catecholamine storage in Adrenal Chromaffin Granules

Properties of Tyrosine Hydroxylase

Cofactors of Tyrosine Hydroxylase

Characterization of dopa decarboxylase

Characterization, Localization and Regulation of Catecholamine Synthesizing Enzymes

Immunological Localisation of Dopamine-β-Hydroxylase on the Chromaffin Granule Membrane

New Inhibitors of Microbial Origin for Dopamine-β-Hydroxylase

Picolinic Acid Derivatives as Inhibitors of Dopamine β-Hydroxylase In Vivo; their Effects on Blood Pressure and Stress Ulcer

The Innervation of Cerebral Blood Vessels by Central Noradrenergic Neurons

Comparative Studies on Bovine and Guinea Pig Tyrosine Hydroxylase

Regulation of Phenylethanolamine N-Methyltransferase


The cellular Localization and Physiological Role of Catechol-O-Methyltransferase in the Body

Immunological Characterization of Catechol-O-Methyltransferase

New Concepts on the N-Methylation Reactions of Biogenic Amines in Adrenal Medulla and Brain

Ring Dehydroxylation of N-Methylation of Noradrenaline and Dopamine in the Intact Rat Brain

Degradation of the Transmitter Amines by Specific Types of Monoamine Oxidases

The Importance of the 'Hydroxylamine Metabolic Route' in Pharmacology, Toxicology and Pharmacokinetics

Some Characteristics of Rat Liver Mitochrondrial Monoamine Oxidases

The Nature of the Electrophoretically Separable Forms of Monoamine Oxidase

Transformation of Monoamine Oxidases and Deamination of Fattyaromatic Monoamines

On the Mechanism of Inhibition of Monoamine Oxidase

Selective Localization of Monoamine oxidase Forms in Rat Mesenteric Artery

Oxidative-Reductive Pathways for Metabolism of Biogenic Aldehydes

Sulfate Conjugates in the Brain

Reporter's Notes

First Session

Second Session

III. Regulation

Trans-synaptic Regulation of Tyrosine Hydroxylase

Modulation of Adrenal Tyrosine Hydroxylase Induction by Serotonin Nerve Function

Role of Catecholamines in Induction of Adrenal Tyrosine Hydroxylase

Dopamine-β-Hydroxylase and the Regulation of Catecholamine Biosynthesis

Retrograde Axonal Transport of Dopamine-β-Hydroxylase

Growth and Development of a Sympathetic Ganglion In Vivo

Studies on the Mechanism of Regulation of Tyrosine Hydroxylase Activity during Nerve Stimulation

Transsynaptic and Humoral Regulation of Adrenal Catecholamine Synthesis in Stress

Transsynaptic Regulation of Tyrosine Hydroxylasein Adrenal Medulla: Possible Role of Cyclic Nucleotides

Comment—Cholinergic Regulation of Tyrosine Hydroxylase

Sympathetic Ganglia in Culture

Lack of Relationship between Noradrenaline Content and Tyrosine Hydroxylase Activity in Cultured Sympathetic Ganglia

Induction of Tyrosine Hydroxylase in Superior Cervical Ganglion by Cold Exposure: Effects of Decentralization and Mecamylamine

Regulation of Catechol Synthesis in an Adrenergic Clone of Mouse Neuroblastoma

Development of the Central Catecholaminergic Neurons of the Rat

Interaction between the Nerve Growth Factor (NGF) and Adrenergic Blocking Agents in Sympathetic Neurons

Neuroblastoma Cells as a Tool for Neuronal Molecular Biology

Reporter's Notes

IV. Synaptic Dynamics of Receptors

The classification of Adrenergic Receptors

Antagonism of Propranolol to Isoproterenol in Guinea-Pig Trachea: Some Cautionary Findings

Regulation of Cyclic AMP Levels in Brain

Regulation of Adenosine 3',5'-Cyclic Monophosphate Metabolism in Hybrid Somatic Cells

Ontogenetic Development of the Catecholamine-Sensitive Adenyl Cyclase Activity of Rat Cerebral Cortex

Role of β-Adrenergic Receptor in the Control of Serotonin N-Acetyltransferase in Rat Pineal

Beta-Adrenergic Regulation of Indole Metabolism in the Pineal Gland

Selective Regulation of the Multiple Molecular form of Cyclic Nucleotide Phosphodiesterase by Norepinephrine and Other Agents

StereoiSomers of Catecholamines

Effects of Catecholamines and Prostaglandins on Cyclic AMP Levels in Brain In Vivo

Development of Antibodies against Catecholamines

Metabolic Responses of Cardiac, Skeletal Muscle, and Fat Cells to Catecholamines

Methods of Approach for the Isolation of β-Adrenergic Receptors

Toward Isolation of a β-Adrenergic Binding Protein

Recent Advances in the Active site Chemistry of the Adrenergic Alpha-Receptor

Operation of Two Epinephrine Receptors and an Acetylcholine Receptor in the Exocrine Cell of the Rat Parotid Gland

Dopamine-, Octopamine- and Serotonin-Sensitive Adenylate Cyclases: Possible Receptors in Aminergic Neurotransmission

Comparison of the Excitatory Action of Acetylcholine and Noradrenaiine on the Guinea-Pig Myometrium

Possible Mechanism of the Action of Catecholamines on Smooth Muscle

Reporter's Notes

V Synaptic Dynamics

Chairman's remarks

Catecholamine Release and Mobilization of Protein

Neuronal and Extraneuronal Catecholamine Uptake Mechanisms

The Possible Importance of Young (large) Amine Storage Granules for Adrenergic Nerve Terminal Function

Conformational Aspects of the Inhibition of Neuronal Uptake of Noradrenaiine by Tricyclic Antidepressants

Composition and Molecular Organization of Chromaffin Granules

A Large Second Pool of Norepinephrine in the Highly Purified Vesicle Fraction from Bovine Splenic Nerve

Effect of Electrolytes on Amine Transport and Release Mechanisms in Nerve Endings

Small Intensely Fluorescent (SIF) Cells In Vivo and In Vitro

Neuronal Catecholamine Storage Vesicles

Secretion and Recovery of Catecholamines by the Adrenal Medulla

New Aspects of the Localization of Catecholamines in Adrenergic Neurons

Plastic Changes of Central Noradrenaline Neurons after 6-Hydroxydopamine

Characterization of Cortical Noradrenergic Axon Terminals with High Resolution Radioautography

Matrix Phase Organization in the Adrenal Chromaffin Granule

Release of Amines from Sympathetic Nerves

Mechanisms of Exocytosis

Immunological Studies of Dopamine β-Hydroxylase as a Marker for Adrenergic Synaptic Vesicles

Mechanisms of Catecholamine Secretion: Dual Feedback Control of Sympathetic Neurotransmitter Secretion; Role of Calcium

The Effect of Transmitter Release on the Dopamine β-Hydroxylase Content of Sympathetic Nerve Terminals

Phospholipids of the Chromaffin Granule Membrane and Catecholamine

Exocytosis at Sympathetic Nerve Terminals

On the Dynamics of Catecholamines Storage Structures in Sympathetic Neurons of the Rat as Studied by Radioautography

New Investigations of the Cardiovascular Actions of Dopamine

Drug Actions on α-Methyl-m-Tyramine, a False Dopaminergic Transmitter in the Rat Striatum

Extraneuronal Uptake of Catecholamines

Regulation of Catecholamine Release

Regulation of Catecholamine Release: The Muscarinic Inhibitory Mechanism

The Regulation of Transmitter Release Elicited by Nerve Stimulation through a Presynaptic Feed-back Mechanism

The Neurogenic Short-term Control of Catecholamine Synthesis and Release in the Sympatho-Adrenal System, as Reflected in the Levels of Endogenous Dopamine and β-Hydroxylated Catecholamines

In Vivo Release of 3H-DA from the Cat Caudate Nucleus

Regulation of Catecholamine Release: α-Receptor Mediated Feed-back Control in Peripheral and Central Neurones

Effect of Impulse Flow on the Release and Synthesis of Dopamine in the Rat Striatum

Effectiveness of Adrenergic Transmitter Concentrations in Synaptic Clefts of Differing Dimensions

Pulse-to-Pulse Modulation of Noradrenaline Release through a Prejunctional α-Receptor Auto-inhibitory Mechanism

Aspects on Prostaglandin and α-Receptor Mediated Control of Transmitter Release from Adrenergic Nerves

Catecholamine Release and Receptors in Brain Slices

Receptor Regulation Studies: Significance of Central Catecholamine Receptors in Cardiovascular Control

Receptor Regulation of Dopamine Turnover

Regulation of DA Synthesis in the Nigro Neostriatal System

Synthesis and Preferential Release of Newly Formed Norepinephrine during Increased Sympathetic Activity

Decentralization Increases Noradrenaline Release from Field-Stimulated Rat Irides

Effect of Acetylcholine on the Release of 3H-Norepinephrine by Nicotine and Potassium Chloride from Rat Brain Slices

Reporter's Notes

First session

Second Session

VI. Catecholamines in Central Nervous System

Introductory Remarks: Regional Economy and Families of Neuroregulatory Substances

Chairman's Introductory Remarks

Central Catecholamines and Hypertension

Norepinephrine as a Central Synaptic Transmitter

Central Dopaminergic Neurons: Neurophysiological Identification and Responses to Drugs

Existence of Dopaminergic Nerve Terminals in the Rat cortex

Excitatory Effects of Catecholamines in the C.N.S.

Genetic Factors in the Control of Brain Levels of Biogenic Amines and Brain Excitability

Catecholamine Receptor Mechanisms in Vertebrates

Excitatory Effects of Dopamine on Molluscan Neurones

Analysis of Dopamine Specific, Excitatory and Inhibitory Neurons of the Snail

Dopaminergic Transmission in Relation to Mechanisms Underlying Stereotyped Behavior

Histochemical Demonstration of Monoamine Neuron Systems in the Human Fetal

Glyoxylic Acid Condensation: A new Fluorescence Histochemical Method for Sensitive and Detailed Tracing of Central Catecholamine Neurons

Behavioral-Anatomical Correlates of Central Catecholamine Neurons

Behavioral Pharmacology of 6-Hydroxydopamine

Biochemical and Behavioral Alterations following 6-Hydroxydopamine Administration into Brain

Inhibition of the Blood Pressure Response to α-Methyldopa in Unanesthetised Renal Hypertensive Rats by Neonatal 6-Hydroxydopamine (6-OHDA) Treatment

Biogenic Amines and Their Metabolism in the Study of Aggressive Behavior in Rats

Brain Norepinephrine and Ingestive Behavior

Effects on Feeding Behavior after Intrahypothalamic Injections of 6-Hydroxydopamine in Rats

Brain Stem Norepinephrine: Behavioral and Biochemical Differentiation of Responses to Foot Shock in Rats

The Coerulo-Cortical Norepinephrine System and Learning

Electrical Self-stimulation in the Locus Coeruleus and Norepinephrine Turnover in Cerebral Cortex

Effects of 6-Hydroxydopa

Cholinergic-Dopaminergic Relation in Different Brain Structures

Changes in Striatal DA Metabolism Induced by Cholinergic and Anticholinergic Nigral Stimulation in the Rat

Role of Catecholamines in the Control of the Sleep-Waking Cycle

Catecholamine Mechanisms: Their Presumptive Role in the Generation of REM Sleep PGO Waves

Effects on Precise Motor Responding of Bilateral 6-Hydroxydopamine Infusion into the Substantia Nigra

Telencephalic Distribution of Terminals of Brainstem Norepinephrine Neurons

Biochemical Evidence for Interaction Phenomena between Noradrenergic and Serotoninergic Systems in the Cat Brain

NE-Neuronsand Phasic Sleep Phenomena

Dopamine and Acetylcholine Neurones in Striatal and Limbic Structures: Effect of Neuroleptic Drugs

Role of Catecholamines in Neuroendocrine Function

Recent Morphological and Functional Studies on Hypothalamic Dopaminergic and Noradrenergic Mechanisms

Effect of Pregnancy and Sex Hormones on the Transmitter Level in Uterine Short Adrenergic Neurons

Catecholamines in Sexual Hormone Regulation: Forebrain Influence on Tubero-Infundibular Dopamine Neurons and Interaction with Cholinergic Systems

Effects of Catecholamines on Supraoptic Nucleus Neurones in Organ Culture

Catecholamines in Non-neural Cells of the CNS: A Possibility

Catecholamines and the Secretion of Renin, ActH and Growth Hormone

L-DOPA and Pancreatic Secretion

Catecholamine Biosynthetic Enzymes in Pancreatic Islet Cells

Brain Monoamines Participation in the Control of Growth Hormone Secretion in Different Animal Species

Effects of L-DOPA on Prolactin Secretion in Humans

Hypothalamic Catecholamines (CA) and the Secretion of Gonadotropins and Gonadotropin Releasing Hormones

Role of Sympathetic Fibers and of Adrenal Medulla in the Maintenance of Cardiovascular Homeostasis in Normotensive and Hypertensive Rats

Sodium and Catecholamine Excretion

Hypertension, Antihypertensive Drugs, and Norepinephrine in Blood Vessels

Intracisternal 6-Hydroxydopamine (6-OHDA) and 5,6-Dihydroxytryptamine (5,6-DHT) in Experimental Hypertension

Central Adrenergic Neurons and the Control of Blood Pressure

The Central Neural Regulation by Baroreceptors of Peripheral Catecholaminergic Mechanisms

Genetic Variation of the Catecholamine Biosynthetic Enzyme Activities in Various Strains of Rats Including the Spontaneously Hypertensive Rat

Norepinephrine Synthesis and Turnover in the Brain: Acceleration by Physostigmine

Aminoacyl Derivatives of Dopamine as Orally Effective Renal Vasodilators

Reporter's Notes

First session

Second session

VII. Amphetamines and Other Drugs of Abuse

Clinical Pharmocological Study and EEG changes of Delta-9-Tetrahydrocannabinol Effects in Human Volunteers

Amphetamine and Cocaine on Amine Turnover

Comparative Metabolism of Some Amphetamines in Various Species

Behavioral Pharmacology of D-Amphetamine: Some Metabolic and Pharmacological Considerations

Catecholamine Metabolism and Amphetamine Effects on Sensitive and Insensitive Mice

Effects of d-Amphetamine on Body Temperature and on Behavioral Thermoregulation in Rats

The Metabolism and Excretion of 'Amphetamines' in Man

The Postsynaptic Effect of Amphetamine on Striatal Dopamine-sensitive Neurones

Electrophysiological Effects of Amphetamine on Dopaminergic Neurons

Amphetamine and Noradrenergic Reward Pathways

Operant Behavioral Demonstration of Qualitative Differences between the d- and l-ISomers of Amphetamine

Dissociation of Amphetamine-Induced Release of Norepinephrine from Inhibition of Neuronal Uptake in Isolated Brain Tissue

Amphetamine and Methylphenidate Psychosis

Amphetamine Metabolism in Amphetamine-Induced Psychosis

On Amphetamine Tolerance and Abstinence in Rats

Behavioral and Biochemical Effects of L-DOPA in Psychiatric Patients

Halogen Substitution of Amphetamine Biochemical and Pharmacological Consequences

Narcotic Analgesics and the Regulation of Neuronal Catecholamine Stores

Effect of Methadone on Brain Dopamine Metabolism

Effects of Some Tetrahydrocannabinols on the Biosynthesis and Utilization of Catecholamines in the Rat Brain

Alcohol and Catecholamine Disposition: A Role for Tetrahydroisoquinoline Alkaloids

On the Possible Interrelationship in Mechanism of Action between Morphine, Amphetamine and Neuroleptic Drugs

Importance of Brain Dopamine for the Stimulant Actions of Amphetamine

p-Hydroxynorephedrine: Its Selective Distribution in Different Rat Brain Areas

The Effect of Morphine on Rat Brain Catecholamines: Turnover In Vivo and Uptake in Isolated SynaptoSomes

Psychopharmacological Profile of Cocaine

Reporter's Notes

VIII. Catecholamines in Man

Catecholamine Metabolites in CSF

Metabolites of Catecholamines in the Cerebrospinal Fluid

Selective Depletion of Brain Regional Noradrenaline by Systemic 6-Hydroxydopamine in Newborn Rats

VMA in Spinal Fluid: Evaluation of the Pathways of Cerebral Catecholamine Metabolism in Man

Oxygen-18 in Measurement of Dopamine Turnover in Rat Brain

Technical Strategies for the Study of Catecholamines in Man

Cyclic AMP and a Possible Animal Model of Receptor Supersensitivity

Application of Mass Fragmentography to the Quantitation of Endogenous Catecholamines

The Identification of Depressed Patients who have a Disorder of NE Metabolism and/or Disposition

Monoamine Neuron Systems in the Normal and Schizophrenic Human Brain: Fluorescence Histochemistry of Fetal, Neurosurgical and Post Mortem Material

Metabolism of Dopamine and L-DOPA in Human Brain

Changes in Human Serum Dopamine-β-Hydroxylase Activity in various Physiological and Pathological States

Dopamine-β-Hydroxylase Activity in Serum

Plasma Dopamine-β-Hydroxylase in Identical Twins Discordant for Schizophrenia

Catecholamine Metabolism and Neurologic Disease

Amines in Schizophrenia

Implications of Feedback Control in Catecholamine Neuronal Systems

Increased Serum Dopamine-β-Hydroxylase Activity during Neurogenic Hypertension in Quadriplegia

Hypothalamic Releasing Hormones and Catecholamines: A New Interface

Affective Disorders: The Catecholamine Hypothesis Revisited

Catecholamine Metabolism and Affective Disorders: Studies of MHPG Excretion

Collaborative Psychopharmacologic Studies Exploring Catecholamine Metabolism in Psychiatric Disorders

Reporter's Notes

IX. Closing Remarks



No. of pages:
© Pergamon 1973
1st January 1973
eBook ISBN:

About the Editors

Earl Usdin

Solomon H. Snyder

Ratings and Reviews