Frontiers in Catecholamine Research

Frontiers in Catecholamine Research

Proceedings of the Third International Catecholamine Symposium Held at the University of Strasbourg, Strasbourg, France May 20–25, 1973

1st Edition - January 1, 1973

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  • Editors: Earl Usdin, Solomon H. Snyder
  • eBook ISBN: 9781483155869

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Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973. This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.

Table of Contents

  • Foreword





    I. Keynote Address

    The Impact of Monoamine Research on Drug Development

    II. Enzymes

    Two Mechanisms of Catecholamine storage in Adrenal Chromaffin Granules

    Properties of Tyrosine Hydroxylase

    Cofactors of Tyrosine Hydroxylase

    Characterization of dopa decarboxylase

    Characterization, Localization and Regulation of Catecholamine Synthesizing Enzymes

    Immunological Localisation of Dopamine-β-Hydroxylase on the Chromaffin Granule Membrane

    New Inhibitors of Microbial Origin for Dopamine-β-Hydroxylase

    Picolinic Acid Derivatives as Inhibitors of Dopamine β-Hydroxylase In Vivo; their Effects on Blood Pressure and Stress Ulcer

    The Innervation of Cerebral Blood Vessels by Central Noradrenergic Neurons

    Comparative Studies on Bovine and Guinea Pig Tyrosine Hydroxylase

    Regulation of Phenylethanolamine N-Methyltransferase


    The cellular Localization and Physiological Role of Catechol-O-Methyltransferase in the Body

    Immunological Characterization of Catechol-O-Methyltransferase

    New Concepts on the N-Methylation Reactions of Biogenic Amines in Adrenal Medulla and Brain

    Ring Dehydroxylation of N-Methylation of Noradrenaline and Dopamine in the Intact Rat Brain

    Degradation of the Transmitter Amines by Specific Types of Monoamine Oxidases

    The Importance of the 'Hydroxylamine Metabolic Route' in Pharmacology, Toxicology and Pharmacokinetics

    Some Characteristics of Rat Liver Mitochrondrial Monoamine Oxidases

    The Nature of the Electrophoretically Separable Forms of Monoamine Oxidase

    Transformation of Monoamine Oxidases and Deamination of Fattyaromatic Monoamines

    On the Mechanism of Inhibition of Monoamine Oxidase

    Selective Localization of Monoamine oxidase Forms in Rat Mesenteric Artery

    Oxidative-Reductive Pathways for Metabolism of Biogenic Aldehydes

    Sulfate Conjugates in the Brain

    Reporter's Notes

    First Session

    Second Session

    III. Regulation

    Trans-synaptic Regulation of Tyrosine Hydroxylase

    Modulation of Adrenal Tyrosine Hydroxylase Induction by Serotonin Nerve Function

    Role of Catecholamines in Induction of Adrenal Tyrosine Hydroxylase

    Dopamine-β-Hydroxylase and the Regulation of Catecholamine Biosynthesis

    Retrograde Axonal Transport of Dopamine-β-Hydroxylase

    Growth and Development of a Sympathetic Ganglion In Vivo

    Studies on the Mechanism of Regulation of Tyrosine Hydroxylase Activity during Nerve Stimulation

    Transsynaptic and Humoral Regulation of Adrenal Catecholamine Synthesis in Stress

    Transsynaptic Regulation of Tyrosine Hydroxylasein Adrenal Medulla: Possible Role of Cyclic Nucleotides

    Comment—Cholinergic Regulation of Tyrosine Hydroxylase

    Sympathetic Ganglia in Culture

    Lack of Relationship between Noradrenaline Content and Tyrosine Hydroxylase Activity in Cultured Sympathetic Ganglia

    Induction of Tyrosine Hydroxylase in Superior Cervical Ganglion by Cold Exposure: Effects of Decentralization and Mecamylamine

    Regulation of Catechol Synthesis in an Adrenergic Clone of Mouse Neuroblastoma

    Development of the Central Catecholaminergic Neurons of the Rat

    Interaction between the Nerve Growth Factor (NGF) and Adrenergic Blocking Agents in Sympathetic Neurons

    Neuroblastoma Cells as a Tool for Neuronal Molecular Biology

    Reporter's Notes

    IV. Synaptic Dynamics of Receptors

    The classification of Adrenergic Receptors

    Antagonism of Propranolol to Isoproterenol in Guinea-Pig Trachea: Some Cautionary Findings

    Regulation of Cyclic AMP Levels in Brain

    Regulation of Adenosine 3',5'-Cyclic Monophosphate Metabolism in Hybrid Somatic Cells

    Ontogenetic Development of the Catecholamine-Sensitive Adenyl Cyclase Activity of Rat Cerebral Cortex

    Role of β-Adrenergic Receptor in the Control of Serotonin N-Acetyltransferase in Rat Pineal

    Beta-Adrenergic Regulation of Indole Metabolism in the Pineal Gland

    Selective Regulation of the Multiple Molecular form of Cyclic Nucleotide Phosphodiesterase by Norepinephrine and Other Agents

    StereoiSomers of Catecholamines

    Effects of Catecholamines and Prostaglandins on Cyclic AMP Levels in Brain In Vivo

    Development of Antibodies against Catecholamines

    Metabolic Responses of Cardiac, Skeletal Muscle, and Fat Cells to Catecholamines

    Methods of Approach for the Isolation of β-Adrenergic Receptors

    Toward Isolation of a β-Adrenergic Binding Protein

    Recent Advances in the Active site Chemistry of the Adrenergic Alpha-Receptor

    Operation of Two Epinephrine Receptors and an Acetylcholine Receptor in the Exocrine Cell of the Rat Parotid Gland

    Dopamine-, Octopamine- and Serotonin-Sensitive Adenylate Cyclases: Possible Receptors in Aminergic Neurotransmission

    Comparison of the Excitatory Action of Acetylcholine and Noradrenaiine on the Guinea-Pig Myometrium

    Possible Mechanism of the Action of Catecholamines on Smooth Muscle

    Reporter's Notes

    V Synaptic Dynamics

    Chairman's remarks

    Catecholamine Release and Mobilization of Protein

    Neuronal and Extraneuronal Catecholamine Uptake Mechanisms

    The Possible Importance of Young (large) Amine Storage Granules for Adrenergic Nerve Terminal Function

    Conformational Aspects of the Inhibition of Neuronal Uptake of Noradrenaiine by Tricyclic Antidepressants

    Composition and Molecular Organization of Chromaffin Granules

    A Large Second Pool of Norepinephrine in the Highly Purified Vesicle Fraction from Bovine Splenic Nerve

    Effect of Electrolytes on Amine Transport and Release Mechanisms in Nerve Endings

    Small Intensely Fluorescent (SIF) Cells In Vivo and In Vitro

    Neuronal Catecholamine Storage Vesicles

    Secretion and Recovery of Catecholamines by the Adrenal Medulla

    New Aspects of the Localization of Catecholamines in Adrenergic Neurons

    Plastic Changes of Central Noradrenaline Neurons after 6-Hydroxydopamine

    Characterization of Cortical Noradrenergic Axon Terminals with High Resolution Radioautography

    Matrix Phase Organization in the Adrenal Chromaffin Granule

    Release of Amines from Sympathetic Nerves

    Mechanisms of Exocytosis

    Immunological Studies of Dopamine β-Hydroxylase as a Marker for Adrenergic Synaptic Vesicles

    Mechanisms of Catecholamine Secretion: Dual Feedback Control of Sympathetic Neurotransmitter Secretion; Role of Calcium

    The Effect of Transmitter Release on the Dopamine β-Hydroxylase Content of Sympathetic Nerve Terminals

    Phospholipids of the Chromaffin Granule Membrane and Catecholamine

    Exocytosis at Sympathetic Nerve Terminals

    On the Dynamics of Catecholamines Storage Structures in Sympathetic Neurons of the Rat as Studied by Radioautography

    New Investigations of the Cardiovascular Actions of Dopamine

    Drug Actions on α-Methyl-m-Tyramine, a False Dopaminergic Transmitter in the Rat Striatum

    Extraneuronal Uptake of Catecholamines

    Regulation of Catecholamine Release

    Regulation of Catecholamine Release: The Muscarinic Inhibitory Mechanism

    The Regulation of Transmitter Release Elicited by Nerve Stimulation through a Presynaptic Feed-back Mechanism

    The Neurogenic Short-term Control of Catecholamine Synthesis and Release in the Sympatho-Adrenal System, as Reflected in the Levels of Endogenous Dopamine and β-Hydroxylated Catecholamines

    In Vivo Release of 3H-DA from the Cat Caudate Nucleus

    Regulation of Catecholamine Release: α-Receptor Mediated Feed-back Control in Peripheral and Central Neurones

    Effect of Impulse Flow on the Release and Synthesis of Dopamine in the Rat Striatum

    Effectiveness of Adrenergic Transmitter Concentrations in Synaptic Clefts of Differing Dimensions

    Pulse-to-Pulse Modulation of Noradrenaline Release through a Prejunctional α-Receptor Auto-inhibitory Mechanism

    Aspects on Prostaglandin and α-Receptor Mediated Control of Transmitter Release from Adrenergic Nerves

    Catecholamine Release and Receptors in Brain Slices

    Receptor Regulation Studies: Significance of Central Catecholamine Receptors in Cardiovascular Control

    Receptor Regulation of Dopamine Turnover

    Regulation of DA Synthesis in the Nigro Neostriatal System

    Synthesis and Preferential Release of Newly Formed Norepinephrine during Increased Sympathetic Activity

    Decentralization Increases Noradrenaline Release from Field-Stimulated Rat Irides

    Effect of Acetylcholine on the Release of 3H-Norepinephrine by Nicotine and Potassium Chloride from Rat Brain Slices

    Reporter's Notes

    First session

    Second Session

    VI. Catecholamines in Central Nervous System

    Introductory Remarks: Regional Economy and Families of Neuroregulatory Substances

    Chairman's Introductory Remarks

    Central Catecholamines and Hypertension

    Norepinephrine as a Central Synaptic Transmitter

    Central Dopaminergic Neurons: Neurophysiological Identification and Responses to Drugs

    Existence of Dopaminergic Nerve Terminals in the Rat cortex

    Excitatory Effects of Catecholamines in the C.N.S.

    Genetic Factors in the Control of Brain Levels of Biogenic Amines and Brain Excitability

    Catecholamine Receptor Mechanisms in Vertebrates

    Excitatory Effects of Dopamine on Molluscan Neurones

    Analysis of Dopamine Specific, Excitatory and Inhibitory Neurons of the Snail

    Dopaminergic Transmission in Relation to Mechanisms Underlying Stereotyped Behavior

    Histochemical Demonstration of Monoamine Neuron Systems in the Human Fetal

    Glyoxylic Acid Condensation: A new Fluorescence Histochemical Method for Sensitive and Detailed Tracing of Central Catecholamine Neurons

    Behavioral-Anatomical Correlates of Central Catecholamine Neurons

    Behavioral Pharmacology of 6-Hydroxydopamine

    Biochemical and Behavioral Alterations following 6-Hydroxydopamine Administration into Brain

    Inhibition of the Blood Pressure Response to α-Methyldopa in Unanesthetised Renal Hypertensive Rats by Neonatal 6-Hydroxydopamine (6-OHDA) Treatment

    Biogenic Amines and Their Metabolism in the Study of Aggressive Behavior in Rats

    Brain Norepinephrine and Ingestive Behavior

    Effects on Feeding Behavior after Intrahypothalamic Injections of 6-Hydroxydopamine in Rats

    Brain Stem Norepinephrine: Behavioral and Biochemical Differentiation of Responses to Foot Shock in Rats

    The Coerulo-Cortical Norepinephrine System and Learning

    Electrical Self-stimulation in the Locus Coeruleus and Norepinephrine Turnover in Cerebral Cortex

    Effects of 6-Hydroxydopa

    Cholinergic-Dopaminergic Relation in Different Brain Structures

    Changes in Striatal DA Metabolism Induced by Cholinergic and Anticholinergic Nigral Stimulation in the Rat

    Role of Catecholamines in the Control of the Sleep-Waking Cycle

    Catecholamine Mechanisms: Their Presumptive Role in the Generation of REM Sleep PGO Waves

    Effects on Precise Motor Responding of Bilateral 6-Hydroxydopamine Infusion into the Substantia Nigra

    Telencephalic Distribution of Terminals of Brainstem Norepinephrine Neurons

    Biochemical Evidence for Interaction Phenomena between Noradrenergic and Serotoninergic Systems in the Cat Brain

    NE-Neuronsand Phasic Sleep Phenomena

    Dopamine and Acetylcholine Neurones in Striatal and Limbic Structures: Effect of Neuroleptic Drugs

    Role of Catecholamines in Neuroendocrine Function

    Recent Morphological and Functional Studies on Hypothalamic Dopaminergic and Noradrenergic Mechanisms

    Effect of Pregnancy and Sex Hormones on the Transmitter Level in Uterine Short Adrenergic Neurons

    Catecholamines in Sexual Hormone Regulation: Forebrain Influence on Tubero-Infundibular Dopamine Neurons and Interaction with Cholinergic Systems

    Effects of Catecholamines on Supraoptic Nucleus Neurones in Organ Culture

    Catecholamines in Non-neural Cells of the CNS: A Possibility

    Catecholamines and the Secretion of Renin, ActH and Growth Hormone

    L-DOPA and Pancreatic Secretion

    Catecholamine Biosynthetic Enzymes in Pancreatic Islet Cells

    Brain Monoamines Participation in the Control of Growth Hormone Secretion in Different Animal Species

    Effects of L-DOPA on Prolactin Secretion in Humans

    Hypothalamic Catecholamines (CA) and the Secretion of Gonadotropins and Gonadotropin Releasing Hormones

    Role of Sympathetic Fibers and of Adrenal Medulla in the Maintenance of Cardiovascular Homeostasis in Normotensive and Hypertensive Rats

    Sodium and Catecholamine Excretion

    Hypertension, Antihypertensive Drugs, and Norepinephrine in Blood Vessels

    Intracisternal 6-Hydroxydopamine (6-OHDA) and 5,6-Dihydroxytryptamine (5,6-DHT) in Experimental Hypertension

    Central Adrenergic Neurons and the Control of Blood Pressure

    The Central Neural Regulation by Baroreceptors of Peripheral Catecholaminergic Mechanisms

    Genetic Variation of the Catecholamine Biosynthetic Enzyme Activities in Various Strains of Rats Including the Spontaneously Hypertensive Rat

    Norepinephrine Synthesis and Turnover in the Brain: Acceleration by Physostigmine

    Aminoacyl Derivatives of Dopamine as Orally Effective Renal Vasodilators

    Reporter's Notes

    First session

    Second session

    VII. Amphetamines and Other Drugs of Abuse

    Clinical Pharmocological Study and EEG changes of Delta-9-Tetrahydrocannabinol Effects in Human Volunteers

    Amphetamine and Cocaine on Amine Turnover

    Comparative Metabolism of Some Amphetamines in Various Species

    Behavioral Pharmacology of D-Amphetamine: Some Metabolic and Pharmacological Considerations

    Catecholamine Metabolism and Amphetamine Effects on Sensitive and Insensitive Mice

    Effects of d-Amphetamine on Body Temperature and on Behavioral Thermoregulation in Rats

    The Metabolism and Excretion of 'Amphetamines' in Man

    The Postsynaptic Effect of Amphetamine on Striatal Dopamine-sensitive Neurones

    Electrophysiological Effects of Amphetamine on Dopaminergic Neurons

    Amphetamine and Noradrenergic Reward Pathways

    Operant Behavioral Demonstration of Qualitative Differences between the d- and l-ISomers of Amphetamine

    Dissociation of Amphetamine-Induced Release of Norepinephrine from Inhibition of Neuronal Uptake in Isolated Brain Tissue

    Amphetamine and Methylphenidate Psychosis

    Amphetamine Metabolism in Amphetamine-Induced Psychosis

    On Amphetamine Tolerance and Abstinence in Rats

    Behavioral and Biochemical Effects of L-DOPA in Psychiatric Patients

    Halogen Substitution of Amphetamine Biochemical and Pharmacological Consequences

    Narcotic Analgesics and the Regulation of Neuronal Catecholamine Stores

    Effect of Methadone on Brain Dopamine Metabolism

    Effects of Some Tetrahydrocannabinols on the Biosynthesis and Utilization of Catecholamines in the Rat Brain

    Alcohol and Catecholamine Disposition: A Role for Tetrahydroisoquinoline Alkaloids

    On the Possible Interrelationship in Mechanism of Action between Morphine, Amphetamine and Neuroleptic Drugs

    Importance of Brain Dopamine for the Stimulant Actions of Amphetamine

    p-Hydroxynorephedrine: Its Selective Distribution in Different Rat Brain Areas

    The Effect of Morphine on Rat Brain Catecholamines: Turnover In Vivo and Uptake in Isolated SynaptoSomes

    Psychopharmacological Profile of Cocaine

    Reporter's Notes

    VIII. Catecholamines in Man

    Catecholamine Metabolites in CSF

    Metabolites of Catecholamines in the Cerebrospinal Fluid

    Selective Depletion of Brain Regional Noradrenaline by Systemic 6-Hydroxydopamine in Newborn Rats

    VMA in Spinal Fluid: Evaluation of the Pathways of Cerebral Catecholamine Metabolism in Man

    Oxygen-18 in Measurement of Dopamine Turnover in Rat Brain

    Technical Strategies for the Study of Catecholamines in Man

    Cyclic AMP and a Possible Animal Model of Receptor Supersensitivity

    Application of Mass Fragmentography to the Quantitation of Endogenous Catecholamines

    The Identification of Depressed Patients who have a Disorder of NE Metabolism and/or Disposition

    Monoamine Neuron Systems in the Normal and Schizophrenic Human Brain: Fluorescence Histochemistry of Fetal, Neurosurgical and Post Mortem Material

    Metabolism of Dopamine and L-DOPA in Human Brain

    Changes in Human Serum Dopamine-β-Hydroxylase Activity in various Physiological and Pathological States

    Dopamine-β-Hydroxylase Activity in Serum

    Plasma Dopamine-β-Hydroxylase in Identical Twins Discordant for Schizophrenia

    Catecholamine Metabolism and Neurologic Disease

    Amines in Schizophrenia

    Implications of Feedback Control in Catecholamine Neuronal Systems

    Increased Serum Dopamine-β-Hydroxylase Activity during Neurogenic Hypertension in Quadriplegia

    Hypothalamic Releasing Hormones and Catecholamines: A New Interface

    Affective Disorders: The Catecholamine Hypothesis Revisited

    Catecholamine Metabolism and Affective Disorders: Studies of MHPG Excretion

    Collaborative Psychopharmacologic Studies Exploring Catecholamine Metabolism in Psychiatric Disorders

    Reporter's Notes

    IX. Closing Remarks


Product details

  • No. of pages: 1236
  • Language: English
  • Copyright: © Pergamon 1973
  • Published: January 1, 1973
  • Imprint: Pergamon
  • eBook ISBN: 9781483155869

About the Editors

Earl Usdin

Solomon H. Snyder

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