From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

1st Edition - May 8, 2020

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  • Editor: Christopher Langmead
  • eBook ISBN: 9780128201886
  • Hardcover ISBN: 9780128201879

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Description

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.

Key Features

  • Includes the authority and expertise of leading contributors in pharmacology
  • Presents the latest release in the Advances in Pharmacology series

Readership

Investigators in neuroscience, pharmacology, neurology, psychiatry, medicine

Table of Contents

      1. The computational modeling of allosteric modulation of metabotropic glutamate receptors
      2. Laura Pérez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary Tresadern

      3. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators
      4. Kirstie A. Bennett, John A. Christopher and Benjamin G. Tehan

      5. The function and allosteric control of the human sweet taste receptor
      6. Guy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole Servant

      7. The different aspects of the GABAB receptor allosteric modulation
      8. Julie Kniazeff

      9. RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors
      10. Augen A. Pioszak and Debbie L. Hay

      11. Strategies and considerations of G-protein-coupled receptor photopharmacology
      12. Alice E. Berizzi and Cyril Goudet

      13. Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacology
      14. Francis S. Willard, Joseph D. Ho and Kyle W. Sloop

      15. Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations
      16. Kari A. Johnson and David M. Lovinger

      17. Allosteric modulation of muscarinic receptors in alcohol and substance use disorders
      18. Leigh C. Walker and Andrew J. Lawrence

      19. M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?

    Miriam Scarpa, Sarah Hesse and Sophie J. Bradley

Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: May 8, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128201886
  • Hardcover ISBN: 9780128201879

About the Serial Volume Editor

Christopher Langmead

Christopher Langmead is at Monash University, Vic, Australia

Affiliations and Expertise

Monash University, Vic, Australia

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