From Molecules to Networks - 2nd Edition

From Molecules to Networks

2nd Edition

An Introduction to Cellular and Molecular Neuroscience

Editors: John H. Byrne Ruth Heidelberger M. Neal Waxham John H. Byrne James L. Roberts
Imprint: Academic Press
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Description

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this 2e to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease.

Key Features


• Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook

• Discusses emerging new understanding of non-classical molecules that affect neuronal signaling

• Full colour, professional graphics throughout

• Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease.

• Companion website for students provides quizzes to aid their comprehension of this material. Manual site for instructors provides figures in Powerpoint and solutions to quizzes.

Readership

Graduate and upper undergraduate students Neuroscience, Physiology, Cellular and Molecular Biology, Pharmacology, Psychology, Biochemistry.

Table of Contents

  1. Cellular Components of Nervous Tissue Patrick R. Hof, Esther A. Nimchinsky, Grahame Kidd, Luz Claudio, and Bruce D. Trapp
  2. Subcellular Organization of the Nervous System: Organelles and Their Functions Scott Brady, David R. Colman, and Peter Brophy
  3. Energy Metabolism in the Brain Gerald A. Dienel
  4. Electronic Properties of Axons and Dendrites John H. Byrne and Gordon M. Shepherd
  5. Membrane Potential and Action Potential David A. McCormick
  6. Molecular Properties of Ion Channels David Matthew Young, Yuh Nung Jan, and Lily Yeh Jan
  7. Dynamical Properties of Excitable Membranes Douglas A. Baxter and John H. Byrne
  8. Release of Neurotransmitters Robert S. Zucker, Dimitri M. Kullmann, and Thomas L. Schwarz
  9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters Ariel Y. Deutch and Robert H. Roth
  10. Peptides, Growth Factors, Gasses and Other Neurotransmitters Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts
  11. Neurotransmitter Receptors M. Neal Waxham
  12. Intracellular Signalling Howard Schulman
  13. Regulation of Neuronal Gene Expression and Protein Synthesis James L. Roberts and James R. Lundblad
  14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways Paul D. Smolen, Douglas A. Baxter, and John H. Byrne
  15. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More Juan C. Sáez and Bruce J. Nicholson
  16. Postsynaptic Potentials and Synaptic Integration John H. Byrne
  17. Complex Information Processing in Dendrites John H. Byrne and Gordon M. Shepherd<BR id=

Details

Language:
English
Imprint:
Academic Press
eBook ISBN:
9780080920832

About the Editor

John H. Byrne

The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and Memory (CSHP).

Affiliations and Expertise

University of Texas Medical School, Houston, TX, USA

Ruth Heidelberger

Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Heidelberger is an accomplished cellular neurophysiologist specializing in mechanisms of neurotransmitter release. She received her doctoral training under the guidance of Gary Matthews and her postdoctoral training under the direction of Nobel Laureate Erwin Neher. Dr. Heidelberger is a former president and executive board member of the Biophysical Society's Subgroup on Exocytosis and Endocytosis and serves on the editorial board of the Journal of Neurophysiology. She has directed and taught graduate-level courses in cellular neurophysiology and membrane biophysics for more than a decade.

Affiliations and Expertise

The University of Texas Medical School at Houston, Houston, TX, USA

M. Neal Waxham

The William Wheless III Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Waxham’s multi-disciplinary laboratory focuses on the molecular and cellular mechanisms of synaptic function and plasticity. He has developed and directed graduate-level courses in cellular and molecular neurobiology for more than two decades.

Affiliations and Expertise

The University of Texas Medical School at Houston, Houston, TX, USA

John H. Byrne

The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and Memory (CSHP).

Affiliations and Expertise

University of Texas Medical School, Houston, TX, USA

James L. Roberts

Affiliations and Expertise

Trinity University, San Antonio, TX, USA

Reviews

“John H. Byrne and James L. Roberts, who treated us to a superb textbook in their first edition of From Molecules to Networks, have now returned with another outstanding effort in the second edition. They have not only updated their comprehensive book but added to it important new sections on the molecular biology of neurological disorders and on the logic of informational processing by neural networks, the two key themes emerging in modern neuroscience. This book will be welcomed by students and experienced scientists alike as a coherent and valuable resource on cellular and molecular neuroscience.” —Eric R. Kandel, Howard Hughes Medical Institute; Columbia University College of Physicians and Surgeons, New York, USA “The world of neuroscience is extraordinarily broad and complex, ranging from molecular biology through neurotransmission to neuronal networks and brain disease. How can one convey to the student and professional coherently the ‘big picture’ without sacrificing critical detail? In the second edition of their now classic volume, John Byrne and James Roberts accomplish this task with rigor, elegance and, remarkable lucidity…The volume will be indispensable both for student and advanced researcher …” —Solomon H Snyder, Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins University, Baltimore, USA “The development of systems biology across all of biological sciences has underlined the need for a neuroscience book whose goal is to span the range from molecular mechanisms to the neural substrate of behavior. The first edition of Byrne and Roberts was ahead of its time in doing what has now become the fashion. That was a wonderful book, and the second edition is even better. A ‘must have’.” —Charles F. Stevens, Professor and Vincent J. Coates Chair in Molecular Neurobiology, The Salk Institute for Biological Studies, San Diego, USA “This