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From Molecules to Networks - 2nd Edition - ISBN: 9780123741325, 9780080920832

From Molecules to Networks

2nd Edition

An Introduction to Cellular and Molecular Neuroscience

Editors: John Byrne Ruth Heidelberger M. Waxham James L. Roberts
eBook ISBN: 9780080920832
Imprint: Academic Press
Published Date: 23rd January 2009
Page Count: 656
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An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease.

Key Features

  • Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook
  • Discusses emerging new understanding of non-classical molecules that affect neuronal signaling
  • Full colour, professional graphics throughout
  • Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease


Graduate and upper undergraduate students Neuroscience, Physiology, Cellular and Molecular Biology, Pharmacology, Psychology, Biochemistry.

Table of Contents

  1. Cellular Components of Nervous Tissue
    Patrick R. Hof, Esther A. Nimchinsky, Grahame Kidd, Luz Claudio, and Bruce D. Trapp
    2. Subcellular Organization of the Nervous System: Organelles and Their Functions
    Scott Brady, David R. Colman, and Peter Brophy
    3. Energy Metabolism in the Brain
    Gerald A. Dienel
    4. Electronic Properties of Axons and Dendrites
    John H. Byrne and Gordon M. Shepherd
    5. Membrane Potential and Action Potential
    David A. McCormick
    6. Molecular Properties of Ion Channels
    David Matthew Young, Yuh Nung Jan, and Lily Yeh Jan
    7. Dynamical Properties of Excitable Membranes
    Douglas A. Baxter and John H. Byrne
    8. Release of Neurotransmitters
    Robert S. Zucker, Dimitri M. Kullmann, and Thomas L. Schwarz
    9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters
    Ariel Y. Deutch and Robert H. Roth
    10. Peptides, Growth Factors, Gasses and Other Neurotransmitters
    Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts
    11. Neurotransmitter Receptors
    M. Neal Waxham
    12. Intracellular Signalling
    Howard Schulman
    13. Regulation of Neuronal Gene Expression and Protein Synthesis
    James L. Roberts and James R. Lundblad
    14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways
    Paul D. Smolen, Douglas A. Baxter, and John H. Byrne
    15. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More
    Juan C. Sáez and Bruce J. Nicholson
    16. Postsynaptic Potentials and Synaptic Integration
    John H. Byrne
    17. Complex Information Processing in Dendrites
    John H. Byrne and Gordon M. Shepherd
    18. Information Processing in Neural Networks
    James J. Knierim
    19. Learning and Memory: Basic Mechanisms
    John H. Byrne, Kevin S. LeBar, Joseph E. LeDoux, Glenn E. Schafe, Richard F. Thompson, and J. David Sweatt
    20. Molecular and Cellular Mechanisms of Neurodegenerative Disease
    Mark R. Cookson, Randy Strong, P. John Hart, and James L. Roberts


No. of pages:
© Academic Press 2009
23rd January 2009
Academic Press
eBook ISBN:

About the Editors

John Byrne

John Byrne

The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and Memory (CSHP).

Affiliations and Expertise

University of Texas Medical School, Houston, TX, USA

Ruth Heidelberger

Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Heidelberger is an accomplished cellular neurophysiologist specializing in mechanisms of neurotransmitter release. She received her doctoral training under the guidance of Gary Matthews and her postdoctoral training under the direction of Nobel Laureate Erwin Neher. Dr. Heidelberger is a former president and executive board member of the Biophysical Society's Subgroup on Exocytosis and Endocytosis and serves on the editorial board of the Journal of Neurophysiology. She has directed and taught graduate-level courses in cellular neurophysiology and membrane biophysics for more than a decade.

Affiliations and Expertise

The University of Texas Medical School at Houston, Houston, TX, USA

M. Waxham

The William Wheless III Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Waxham’s multi-disciplinary laboratory focuses on the molecular and cellular mechanisms of synaptic function and plasticity. He has developed and directed graduate-level courses in cellular and molecular neurobiology for more than two decades.

Affiliations and Expertise

The University of Texas Medical School at Houston, Houston, TX, USA

James L. Roberts

Affiliations and Expertise

Trinity University, San Antonio, TX, USA


“John H. Byrne and James L. Roberts, who treated us to a superb textbook in their first edition of From Molecules to Networks, have now returned with another outstanding effort in the second edition. They have not only updated their comprehensive book but added to it important new sections on the molecular biology of neurological disorders and on the logic of informational processing by neural networks, the two key themes emerging in modern neuroscience. This book will be welcomed by students and experienced scientists alike as a coherent and valuable resource on cellular and molecular neuroscience.” —Eric R. Kandel, Howard Hughes Medical Institute; Columbia University College of Physicians and Surgeons, New York, USA

“The world of neuroscience is extraordinarily broad and complex, ranging from molecular biology through neurotransmission to neuronal networks and brain disease. How can one convey to the student and professional coherently the ‘big picture’ without sacrificing critical detail? In the second edition of their now classic volume, John Byrne and James Roberts accomplish this task with rigor, elegance and, remarkable lucidity…The volume will be indispensable both for student and advanced researcher …” —Solomon H Snyder, Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins University, Baltimore, USA

“The development of systems biology across all of biological sciences has underlined the need for a neuroscience book whose goal is to span the range from molecular mechanisms to the neural substrate of behavior. The first edition of Byrne and Roberts was ahead of its time in doing what has now become the fashion. That was a wonderful book, and the second edition is even better. A ‘must have’.” —Charles F. Stevens, Professor and Vincent J. Coates Chair in Molecular Neurobiology, The Salk Institute for Biological Studies, San Diego, USA

“This second edition brings up to date a superb neuroscience book, further enhancing its unique original strength—elegance thoroughness, and clarity, contextually presented.” —Rodolfo Llinas, Thomas and Susanne Murphy Professor of Neuroscience and Chairman, New York University Langone Medical Center, New York, USA

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