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From Gene to Protein: Information Transfer in Normal and Abnormal Cells - 1st Edition - ISBN: 9780126044508, 9780323143707

From Gene to Protein: Information Transfer in Normal and Abnormal Cells

1st Edition

Editor: Thomas Russell
eBook ISBN: 9780323143707
Imprint: Academic Press
Published Date: 1st January 1979
Page Count: 668
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Miami Winter Symposia, Volume 16: From Gene to Protein: Information Transfer in Normal and Abnormal Cells presents the expression and processing of genetic information at the levels of both proteins and nucleic acids. This book deals with the reassembly and mobilization of genetic information. Organized into 105 chapters, this volume begins with an overview of the discovery of the double helix and the search for the genetic code and the three-dimensional structure of protein. This text then examines the molecular mechanism by which steroid hormones regulate specific gene expression. Other chapters consider the possible hazards inherent to hybrid DNA technology. This book discusses as well the various problems of gene control in higher organisms, which are illustrated by the changes that occur in the hemoglobin of mammals. The final chapter deals with the characterization of adenovirus-2 mRNAs. This book is a valuable resource for biochemists, genetic engineers, enzymologists, scientists, geneticists, and molecular biologists.

Table of Contents

Speakers, Chairman, and Discussants


How to Live with a Golden Helix

The Ovomucoid Gene: Organization, Structure, and Regulation

Structural Organization and Expression of Ovalbumin and Related Chicken Genes

An Endonuclease-Sensitive Region in Simian Virus 40 Chromatin

Expression of Cloned Viral and Chromosomal Plasmid-Linked DNA in Cognate Host Cells

The Arrangement, Rearrangement, and Origin of Immunoglobulin Genes

The Structure and Expression of Normal and Abnormal Globin Genes

Genomic Clones from Unfractionated DNA

The Processing of Messenger RNA and the Determination of Its Relative Abundance

Steps in Processing of mRNA: Implications for Gene Regulation

5'-Capping and Eukaryotic mRNA Function

Splice Patterns of Adenovirus and Adenovirus-SV40 Mosaic RNA's

Processing of Bacteriophage T7 RNAs by RNase III

Regulation of Promoter Selection by RNA Polymerases

Synthesis and Maturation of Transmembrane Viral Glycoproteins

The Control of Protein Synthesis in Rabbit Reticulocyte Lysates

Determinants in Protein Topology

Precursors in the Biosynthesis of Insulin and Other Peptide Hormones

Biosynthesis and Processing of Glycoproteins

The Enzymatic Conversion of Membrane and Secretory to Glycoproteins

Oligosaccharide Processing during Glycoprotein Biosynthesis

Structural Basis of the Regulation of Galactosyltransferase

Specificity Considerations Relevant to Protein Kinase Activation and Function

The Role of Protein Phosphorylation in the Coordinated Control of Intermediary Metabolism

Protein Phosphatase C: Properties, Specificity, and Structural Relationship to a Larger Holoenzyme

Regulation of Pyruvate Dehydrogenase by Phosphorylation/Dephosphorylation

Allosteric Control of E. coli Glutamine Synthetase is Mediated by a Bicyclic Nucleotidylation Cascade System

Poly(ADP-Ribose) and ADP-Ribosylation of Proteins

Free Communications

Identification of Two Collagen RNAs Larger than α1 and α2 Collagen mRNAs which Are Decreased in Transformed Cells

Processing of RNA in Bacteria

The Protein Moieties of the Nonpolysomal Cytoplasmic (Free) mRNP Complexes of Embryonic Chicken Muscle

Complex Oligosaccharides Assembled on Lipid Intermediates: Studies with UDP-N-Acetylglucosamine and GDP-Mannose

Is There a Different Mode of DNA Synthesis in Normal and Transformed Human Diploid Fibroblasts?

A Study of the DNA Region Coding for Initiation of Precursor rRNA Transcription in Lytechinus variegatus

A Lectin Resistant Variant of Mouse Fibroblasts with Altered Cell Surface Galactose

Alterations in the Rate of Protein Synthesis of Polysomes Extracted from Fibroblasts of Patients with Duchenne Muscular Dystrophy and Carriers of the Disease

Biosynthesis of the Small Nuclear RNAs in a Cell-Free System from Mouse Myeloma Cells

A Shared Control Mechanism for Regulation of Adenovirus and SV40 Gene Expression

In Vitro Synthesis of Virus-Specific RNA Using Transcriptional Complex Isolated from Adenovirus-Infected Cells

Gene Expression of Mammalian Lens Tissue: Coexistence and Properties of Poly(A)-Containing and Poly(A)-Lacking 10S and 14S mRNA Species

Gene Expression of Mammalian Lens Tissue: Is Lens mRNA Bicistronic?

The Expression of α-Fetoprotein Gene in Normal and Neoplastic Rat Liver

Nuclear Phosphoprotein Phosphatase from Calf Liver

Chemically Induced Gene Expression: The Role of Histone Hyperacetylation in Transformation by SV40 Minichromatin

Transcription of the Histone mRNA Precursor during the Cell Cycle

Characterization of a Cytoplasmic Poly(A)-Protein Complex: Endproduct or Byproduct of Messenger RNA Metabolism?

Factors which Influence the Nα-Acetylation of ACTH and Fragments of ACTH

Instability of Higher Plant Chromosomal DNA Molecularly Cloned in E. coli via Recombinant Plasmids

Translation of Endogenous Non-IgG and IgG Messenger RNA in Human Leukemic Plasma Cells after Treatment with Several Alkylating Agents

The in situ Phosphorylation of the α-Subunit of eIF-2 in Reticulocyte Lysates Inhibited by Heme Deficiency, dsRNA, GSSG, or the Heme-Regulated Inhibitor

Purification of Arginyl- and Lysyl-tRNA Synthetases from Rat Liver: Evidence of Glycoproteins

Mammalian Cell Nuclear RNA Ligase Activity

Multiple Forms of α2u Globulin in the Rat Studied in Vivo and in Primary Cultures of Adult Hepatocytes

Biosynthesis of Lysosomal Enzymes in Diploid Human Fibroblasts

Isolation and Partial Characterization of ß-like Globin Genes from Total Genomic Goat DNA

Regulation of Metallothionein Synthesis in Cultured Mammalian Cells: Induction, Deinduction, and Superinduction

A Class of Highly Repeated DNA Sequences Ubiquitous to the Human Genome

Regulation of HMG-CoA Reductase and Reductase Kinase by Reversible Phosphorylation

Structure and Expression of the Alpha Fetoprotein Gene

Control of eIF-2 Phosphorylation in Rabbit Reticulocyte Lysate

Organization of Immunoglobulin Kappa Light Chain Genes in Germ Line and Somatic Cells

Cloning of Fragments of the Sea Urchin Histone Gene Cluster with SV40 DNA as a Vector

Regulation by Metabolites of Inactivating and Additional Phosphorylation Reactions in the Pig Heart Pyruvate Dehydrogenase Complex

Cyclic AMP Stimulation of Ribosomal Phosphoprotein Phosphatase Activity

Unusual Genome Organization of Neurospora crassa

Cloning and Characterization of Alleles of the Natural Ovalbumin Gene Created by Mutations in the Intervening Sequences

Differential Influence of mRNA Cap Metabolism on Protein Synthesis in Differentiating Embryonic Chick Lens Cells

Molecular Studies of Retrodifferentiation Phenomena in Proliferation-Competent Adult Hepatocyte Cultures

Role of Protein Synthesis in the Replication of the "Killer Virus" of Yeast

Effects of the Catalytic Subunit of Protein Kinase II from Reticulocytes and Bovine Heart Muscle on Protein Phosphorylation and Protein Synthesis in Reticulocyte Lysates

Functional Heterogeneity in the RNAs of TYMV Virions

Subcellular Distribution of SV40T Antigen Species in Various Cell Lines

Hormonal Regulation of Protein Biosynthesis in Rat Epididymal Fat Cells: Stimulation by Insulin, Inhibition by Fasting, and Permissive Effects of Adrenal Glucocorticoids

Reversal of Posttranslational Tyrosylation of Tubulin

Salt-Dependent Transcriptional Specificity of T7 RNA Polymerase

Differential Sensitivity of Inhibition of Cyclic AMP Phosphodiesterase in the Thymus during Murine Leukemogenesis

In Vivo Subnuclear Distribution of Larger than Tetrameric Polyadenosine Diphosphoribose in Rat Liver

Processing and Transport of RNA following Mitogenic Stimulation of Human Lymphocytes

Identification of Drosophila 2S rRNA as the 3'-Part of 5.8S rRNA

Facilitation by Pyrimidine Nucleosides and Hypoxanthine of MNNG Mutagenesis in Chinese Hamster Cells

Noncoding Inserts in Hemoglobin and Simian Virus 40 Genes Are Bounded by Self-Complementary Regions

A Variant of Polyoma Virus Altered in Its Processing of Late Viral RNA

Protease-Mediated Morphological Changes Induced by Treatment of Transformed Chick Fibroblasts with a Tumor Promoter: Evidence for Direct Catalytic Involvement of Plasminogen Activator

Recovery of a Transforming Virus from AKR Mouse Tumor Tissue by DNA Transfection

Synthesis and Posttranslational Modification of Retrovirus Precursor Polyproteins Encoded by gag and env Genes

Avian Myeloblastosis Virus (AMV) Linear Duplex DNA: In Vitro Enzymatic Synthesis and Structural Organization Analysis

Studies on the DNA-Directed in Vitro Synthesis of Bacterial Elongation Factor TU

In Vitro Transcription of Ad2 DNA by Eukaryotic RNA Polymerases II. I. Kinetics of Formation of Stable Binary Complexes at Specific Sites

Characterization of Human Fetal γ Globin DNA

Phosphorylation and Inactivation of Glycogen Synthase by a Ca2+ CDR-Dependent Kinase

A Polypeptide in Initiation Factor Preparations That Recognizes the 5'-Terminal Cap in Eukaryotic mRNA

Location and Sequence of a Putative Promoter for the B Gene of Bacteriophage S13

Regulation of Protein Synthesis: Role of NAD+ and Sugar Phosphates in Lysed Rabbit Reticulocytes

The Effect of Cortisol on Glucocorticoid "Resistant" Thymocytes

The Effects of Streptococcus pneumoniae Infection on Hepatic Messenger RNA Production

Identification of Putative Precursors of Ovalbumin and Ovomucoid Messenger RNAs

Purification of mRNA Guanylyl Transferase from HeLa Cells

Emergence of Resistance to Glucocorticoid Hormones in Cancer Cells: Detection of Differences in Proteins Synthesized by Glucocorticoid-Sensitive and -Resistant Mouse P1798 Lymphosarcoma Cells

Complexity and Diversity of Polysomal and Informosomal mRNA from Chinese Hamster Cells

Characterization of a Virion-Associated RNA Polymerase from Killer Yeast

In Vitro Transcription of Ad2 DNA by Eukaryotic RNA Polymerases II. II. Transcription from Stable Binary Complexes

Mouse Fetal Hemoglobin Synthesis in Murine Erythroleukemic Cells

Spectroscopic Probes for Study of Gene Transcription

Positive Transcriptional Control of Inducible Galactose Pathway Enzymes in Yeast

Localization and Characterization of the 5' End of Adenovirus-2 Fiber mRNA


No. of pages:
© Academic Press 1979
1st January 1979
Academic Press
eBook ISBN:

About the Editor

Thomas Russell

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