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Free Radicals in Biology, Volume IV reviews diverse topics in free radical biology and covers topics ranging from radiation biology to lipid peroxidation, radical-mediated liver pathology, and chemical carcinogenesis. Radical mechanisms in prostaglandin biochemistry are also discussed, along with the use of electron spin resonance and spin trap methods to probe mechanisms of radical reactions in biological systems.
Comprised of 10 chapters, this volume begins with an overview of the mechanisms of lipid peroxidation, focusing on the chemistry of fluorescent products from in vivo lipid peroxidation; the production of pentane in the expired breath of animals exposed to oxidative threats; and the chemistry of the enzyme glutathione peroxidase. The next chapter is devoted to the kinetic aspects of lipid peroxidation and the multiple ways in which autoxidants can react. The reader is then introduced to the mechanisms of hepatoxicity by synthetic chemicals present in the environment, together with direct mechanisms of radiation damage to nucleic acids. Subsequent chapters deal with spin trapping in biological systems; the role of free radicals in arylamine carcinogenesis and their influence on the structure and reactivity of melanins; and the involvement of vitamin ? and lipid antioxidants in free-radical-initiated reactions.
This book will be of value to chemists, biologists, and physicians.
List of Contributors
Preface to Volume IV
Contents of Other Volumes
Chapter 1 Measurement of and Protection from in Vivo Lipid Peroxidation
II. Fluorescent Products as a Measure of Lipid Peroxidation
III. Pentane in Breath as a Measure of in Vivo Lipid Peroxidation
IV. Selenium-Glutathione Peroxidase in Protection against in Vivo Lipid Peroxidation
Chapter 2 Free-Radical Damage in Liver
II. Criteria to Define Liver Injury by a Free-Radical Mechanism
III. CCl4: Model Free-Radical Hepatotoxin
IV. Halothane: Potential Free-Radical Hepatotoxin
V. Nonhalogenated Xenobiotics: Probable, Possible, and Proposed Free-Radical Hepatotoxins
Chapter 3 Free-Radical Damages of Nucleic Acids and Their Components: The Direct Absorption of Energy
II. Initial Radical Products
III. Reactions of Initial Products and Identification of Secondary Products
IV. Effects of Conditions
V. Interactions between Neighbors
Chapter 4 A Critical Review of Spin Trapping in Biological Systems
I. Direct Detection of Free Radicals and Radical Ions
II. Indirect Methods of Detecting Free Radicals “Classical” Reactions
III. Spin Trapping: An Indirect esr Method of Detecting Free Radicals
IV. Spin Trapping in Biological Systems
Chapter 5 Production of Radicals from Enzyme Systems and the Use of Spin Traps
II. Spin-Trapping Studies of Phagocytizing Mixed Leukocytes
III. Spin Trapping of Radicals Formed during the Metabolism of Halocarbons by Liver Microsomes
IV. Spin Trapping of Radicals Formed during the Activity of the Xanthine Oxidase System
V. Spin Trapping of a Radical Formed during the Activity of the Lipoxygenase System
VI. Formation of Spin Adducts in Other Biological Systems
VII. In Vivo Spin Trapping of the Trichloromethyl Radical
VIII. Concluding Remarks
Chapter 6 Free Radicals in Arylamine Carcinogenesis
I. Free Radicals and Cancer: Overview
II. Antioxidant-Induced Decrease in Cancer Development
III. Chemistry of Activation of 2-Acetylaminofluorene
IV. Free Radicals in Acetylaminofluorene Activation
V. Reexamination of the Peroxidase-Hydroperoxide Activation of N-OH-AAF
VI. Do Endogenous Peroxidases Activate N-OH-AAF?
VII. Covalent Binding of 2-Nitrosofluorene to Unsaturated Membrane Lipids
VIII. Relevance of the Nitrosofluorene-Lipid Complex to Carcinogenesis
IX. Spin Trapping and Carcinogenesis
X. Summary and Perspective for Future Work
Chapter 7 Structure and Reactivity of Melanins: Influence of Free Radicals and Metal Ions
II. General Properties of Melanins
III. Intrinsic Free Radicals
IV. Interaction with Metal Ions
V. Interaction with Light
VI. Other Chemical Reactions
VII. Role of Solvent and Motional Effects
VIII. Biomedical Applications
IX. Concluding Remarks
Chapter 8 Prostaglandin Endoperoxides
III. Endoperoxide Syntheses
IV. Reactions of Endoperoxides
V. Biological Conversions of Prostaglandin Endoperoxides
Chapter 9 Vitamin Ε and Lipid Antioxidants in Free-Radical-Initiated Reactions
II. Multilevel Control of Free Radicals
III. Vitamin E, Antioxidants, and Polyunsaturated Fatty Acids
IV. Quantitative Aspects of the Vitamin E-PUFA Relationship
V. Fads, Fancies, and Facts Regarding Vitamin Ε
Chapter 10 Stable Radiation-Induced Paramagnetic Entities in Tissue Mineral and Their Use in Calcified Tissue Research
II. Origin of Radiation-Induced Defects in Tissue Mineral
III. Application of the Stable Radiation-Induced Paramagnetic Centers in Studies on Mineralizing Tissues
IV. Spin Dosimetry
- No. of pages:
- © Academic Press 1980
- 28th March 1980
- Academic Press
- eBook ISBN:
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