Free Radicals in Biology V4

Free Radicals in Biology V4

1st Edition - March 28, 1980

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  • Editor: William Pryor
  • eBook ISBN: 9780323153720

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Free Radicals in Biology, Volume IV reviews diverse topics in free radical biology and covers topics ranging from radiation biology to lipid peroxidation, radical-mediated liver pathology, and chemical carcinogenesis. Radical mechanisms in prostaglandin biochemistry are also discussed, along with the use of electron spin resonance and spin trap methods to probe mechanisms of radical reactions in biological systems. Comprised of 10 chapters, this volume begins with an overview of the mechanisms of lipid peroxidation, focusing on the chemistry of fluorescent products from in vivo lipid peroxidation; the production of pentane in the expired breath of animals exposed to oxidative threats; and the chemistry of the enzyme glutathione peroxidase. The next chapter is devoted to the kinetic aspects of lipid peroxidation and the multiple ways in which autoxidants can react. The reader is then introduced to the mechanisms of hepatoxicity by synthetic chemicals present in the environment, together with direct mechanisms of radiation damage to nucleic acids. Subsequent chapters deal with spin trapping in biological systems; the role of free radicals in arylamine carcinogenesis and their influence on the structure and reactivity of melanins; and the involvement of vitamin ? and lipid antioxidants in free-radical-initiated reactions. This book will be of value to chemists, biologists, and physicians.

Table of Contents

  • List of Contributors

    General Preface

    Preface to Volume IV

    Contents of Other Volumes

    Chapter 1 Measurement of and Protection from in Vivo Lipid Peroxidation

    I. Introduction

    II. Fluorescent Products as a Measure of Lipid Peroxidation

    III. Pentane in Breath as a Measure of in Vivo Lipid Peroxidation

    IV. Selenium-Glutathione Peroxidase in Protection against in Vivo Lipid Peroxidation


    Chapter 2 Free-Radical Damage in Liver

    I. Introduction

    II. Criteria to Define Liver Injury by a Free-Radical Mechanism

    III. CCl4: Model Free-Radical Hepatotoxin

    IV. Halothane: Potential Free-Radical Hepatotoxin

    V. Nonhalogenated Xenobiotics: Probable, Possible, and Proposed Free-Radical Hepatotoxins

    VI. Summary


    Chapter 3 Free-Radical Damages of Nucleic Acids and Their Components: The Direct Absorption of Energy

    I. Introduction

    II. Initial Radical Products

    III. Reactions of Initial Products and Identification of Secondary Products

    IV. Effects of Conditions

    V. Interactions between Neighbors


    Chapter 4 A Critical Review of Spin Trapping in Biological Systems

    I. Direct Detection of Free Radicals and Radical Ions

    II. Indirect Methods of Detecting Free Radicals “Classical” Reactions

    III. Spin Trapping: An Indirect esr Method of Detecting Free Radicals

    IV. Spin Trapping in Biological Systems



    Chapter 5 Production of Radicals from Enzyme Systems and the Use of Spin Traps

    I. Introduction

    II. Spin-Trapping Studies of Phagocytizing Mixed Leukocytes

    III. Spin Trapping of Radicals Formed during the Metabolism of Halocarbons by Liver Microsomes

    IV. Spin Trapping of Radicals Formed during the Activity of the Xanthine Oxidase System

    V. Spin Trapping of a Radical Formed during the Activity of the Lipoxygenase System

    VI. Formation of Spin Adducts in Other Biological Systems

    VII. In Vivo Spin Trapping of the Trichloromethyl Radical

    VIII. Concluding Remarks


    Chapter 6 Free Radicals in Arylamine Carcinogenesis

    I. Free Radicals and Cancer: Overview

    II. Antioxidant-Induced Decrease in Cancer Development

    III. Chemistry of Activation of 2-Acetylaminofluorene

    IV. Free Radicals in Acetylaminofluorene Activation

    V. Reexamination of the Peroxidase-Hydroperoxide Activation of N-OH-AAF

    VI. Do Endogenous Peroxidases Activate N-OH-AAF?

    VII. Covalent Binding of 2-Nitrosofluorene to Unsaturated Membrane Lipids

    VIII. Relevance of the Nitrosofluorene-Lipid Complex to Carcinogenesis

    IX. Spin Trapping and Carcinogenesis

    X. Summary and Perspective for Future Work


    Chapter 7 Structure and Reactivity of Melanins: Influence of Free Radicals and Metal Ions

    I. Introduction

    II. General Properties of Melanins

    III. Intrinsic Free Radicals

    IV. Interaction with Metal Ions

    V. Interaction with Light

    VI. Other Chemical Reactions

    VII. Role of Solvent and Motional Effects

    VIII. Biomedical Applications

    IX. Concluding Remarks


    Chapter 8 Prostaglandin Endoperoxides

    I. Introduction

    II. Biosynthesis

    III. Endoperoxide Syntheses

    IV. Reactions of Endoperoxides

    V. Biological Conversions of Prostaglandin Endoperoxides


    Chapter 9 Vitamin Ε and Lipid Antioxidants in Free-Radical-Initiated Reactions

    I. Introduction

    II. Multilevel Control of Free Radicals

    III. Vitamin E, Antioxidants, and Polyunsaturated Fatty Acids

    IV. Quantitative Aspects of the Vitamin E-PUFA Relationship

    V. Fads, Fancies, and Facts Regarding Vitamin Ε

    VI. Summary


    Chapter 10 Stable Radiation-Induced Paramagnetic Entities in Tissue Mineral and Their Use in Calcified Tissue Research

    I. Introduction

    II. Origin of Radiation-Induced Defects in Tissue Mineral

    III. Application of the Stable Radiation-Induced Paramagnetic Centers in Studies on Mineralizing Tissues

    IV. Spin Dosimetry

    V. Conclusions


    Subject Index

Product details

  • No. of pages: 370
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: March 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323153720

About the Editor

William Pryor

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